Professor of Pathology, Professor of Oncology, Johns Hopkins University School of Medicine; Associate Director, Molecular Diagnostics Laboratory
Pathology
Dr. James R. Eshleman, MD
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Doctor James R. Eshleman, MD is an expert in the field of Pathology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. James R. Eshleman is a published doctor. He published 89 publications, including: 'Microsatellite Instability as a Biomarker for PD-1 Blockade.' He accepts Medicare payments and is listed with Medicare.gov.
Publications
- Microsatellite Instability as a Biomarker for PD-1 Blockade.
- Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer.
- A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts.
- Mutational profiling of colorectal cancers with microsatellite instability.
- Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers.
- PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation.
- Challenges posed to pathologists in the detection of KRAS mutations in colorectal cancers.
- Lymph node metastases of melanoma: challenges for BRAF mutation detection.
- Improved FLT3 Internal Tandem Duplication PCR Assay Predicts Outcome after Allogeneic Transplant for Acute Myeloid Leukemia.
- Cytosine deamination is a major cause of baseline noise in next-generation sequencing.
- Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection.
- Familial and sporadic pancreatic cancer share the same molecular pathogenesis.
- False Positives in Multiplex Polymerase Chain Reaction-Based Next-Generation Sequencing Have Unique Signatures.
- BRAF Pyrosequencing Analysis Aided by a Lookup Table.
- Tumor Cellularity as a Quality Assurance Measure for Accurate Clinical Detection of BRAF Mutations in Melanoma.
- Whole-exome sequencing of pancreatic neoplasms with acinar differentiation.
- Microsatellite Instability Confounds Engraftment Analysis of Hematopoietic Stem-cell Transplantation.
- The frequency of KRAS and BRAF mutations in intrahepatic cholangiocarcinomas and their correlation with clinical outcome.
- DNA Mismatch Repair Defects and Microsatellite Instability Status in Periocular Sebaceous Carcinoma.
- Tandem Duplication PCR: An Ultrasensitive Assay for the Detection of Internal Tandem Duplications of the FLT3 Gene.
- Fundamentals of pyrosequencing.
- Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers.
- Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas.
- Detection of Minor Clones With Internal Tandem Duplication Mutations of FLT3 Gene in Acute Myeloid Leukemia Using Delta-PCR.
- Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice.
- Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers.
- Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.
- Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts.
- Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: a tool for pharmacogenetic studies.
- ATM Mutations in Patients with Hereditary Pancreatic Cancer.
- Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.
- Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas.
- Analysis of hematopoietic stem cell transplant engraftment: use of loss or gain of microsatellite alleles to identify residual hematopoietic malignancy.
- Sarcina organisms in the gastrointestinal tract: a clinicopathologic and molecular study.
- Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.
- A protein therapeutic modality founded on molecular regulation.
- Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas.
- Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.
- Genomic Changes in Gliomas Detected Using Single Nucleotide Polymorphism Array in Formalin-Fixed Paraffin-Embedded Tissue Superior Results Compared with Microsatellite...
- Genome-wide analysis of promoter methylation associated with gene expression profiles of pancreatic adenocarcinomas.
- Mutant proteins as cancer-specific biomarkers.
- Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias.
- Δ-PCR, A Simple Method to Detect Translocations and Insertion/Deletion Mutations.
- Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer.
- The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma.
- Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: diagnostic and clinical implications.
- In vivo and in vitro propagation of intraductal papillary mucinous neoplasms.
- Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
- Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology.
- SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.
- Genetic mutations associated with cigarette smoking in pancreatic cancer.
- Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.
- DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.
- Benign nodal nevi frequently harbor the activating V600E BRAF mutation.
- Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influe...
- KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.
- Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for diagnosis and therapy.
- An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.
- Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line.
- Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms.
- Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
- Analysis of nevirapine resistance mutations in cloned HIV type 1 variants from HIV-infected Ugandan infants using a single-step amplification-sequencing method (AmpliS...
- Comparison of LigAmp and an ASPCR assay for detection and quantification of K103N-containing HIV variants.
- Application of traditional clinical pathology quality control techniques to molecular pathology.
- Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, poten...
- A molecular fraction collecting tool for the ABI 310 automated sequencer.
- Development of an integrated assay for detection of BCR-ABL RNA.
- Evaluation of the Cepheid GeneXpert BCR-ABL assay.
- Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells.
- Copy-number methods dramatically underestimate loss of heterozygosity in cancer.
- Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs.
- Sensitivity of the ViroSeq HIV-1 genotyping system for detection of the K103N resistance mutation in HIV-1 subtypes A, C, and D.
- Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers.
- Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.
- Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita.
- A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.
- Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the...
- Capillary electrophoresis artifact due to eosin: implications for the interpretation of molecular diagnostic assays.
- Sequencing of genomic DNA by combined amplification and cycle sequencing reaction.
- LigAmp for sensitive detection of single-nucleotide differences.
- Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles.
- A single nucleotide primer extension assay to detect the APC I1307K gene variant.
- Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.
- Molecular diagnosis of oligodendroglioma in paraffin sections.
- 8-Hydroxyguanosine repair is defective in some microsatellite stable colorectal cancer cells.
- Lack of surface immunoglobulin light chain expression by flow cytometric immunophenotyping can help diagnose peripheral B-cell lymphoma.
- Simultaneous sequencing of multiple polymerase chain reaction products and combined polymerase chain reaction with cycle sequencing in single reactions.
- Advancements in the Development of HIF-1α-Activated Protein Switches for Use in Enzyme Prodrug Therapy.
Schools
Perelman School of Medicine University of Pennsylvania
Temple University Hospital
Hospital Of University Penn
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Education
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University of Pennsylvania Health System -
Temple University Hospital -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Johns Hopkins Bayview Medical Center -
Johns Hopkins Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1447284047 |
| Last Name Of The Provider | ESHLEMAN |
| First Name Of The Provider | JAMES |
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