Professor, Surgery, Vanderbilt University School of Medicine
General Surgery
Dr. James R. Goldenring, MD
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James Goldenring works in the field of General Surgery. He studied medicine at Yale University School of Medicine. Yale University School of Medicine is one of the top medical schools in the US. Yale University School of Medicine is ranked 7 in research and 57 in primary care medicine He over the years received 1 awards: "Elected Member". James Goldenring is a published physician as well. He has 96 publications published. The latest was: miR-30-HNF4 and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach.
Publications
- miR-30-HNF4γ and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach.
- Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach.
- TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.
- Apical vesicle trafficking takes center stage in neonatal enteropathies.
- Gastric Intestinal Metaplasia and Tamoxifen: Can We Reverse the Inevitable?
- Rab11-FIP2 Interaction with MYO5B Regulates Movement of Rab11a-Containing Recycling Vesicles.
- Macrophages Promote Progression of Spasmolytic Polypeptide-Expressing Metaplasia Following Acute Loss of Parietal Cells.
- Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum.
- A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis.
- Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas.
- Rab11-FIP1C and Rab14 Direct Plasma Membrane Sorting and Particle Incorporation of the HIV-1 Envelope Glycoprotein Complex.
- Rab25 regulates integrin expression in polarized colonic epithelial cells.
- Helicobacter pylori promotes the expression of krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo.
- A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells.
- Centrosomal AKAP350 modulates the G1/S transition.
- Rab11-Family Interacting Proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system.
- Sonic Hedgehog contributes to gastric mucosal restitution after injury.
- Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism.
- Proteomic Profiling of Paraffin-Embedded Samples Identifies Metaplasia-Specific and Early-Stage Gastric Cancer Biomarkers.
- Respiratory syncytial virus assembles into structured filamentous virion particles independently of host cytoskeleton and related proteins.
- Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression.
- Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells.
- The Combined Expression of Metaplasia Biomarkers Predicts the Prognosis Of Gastric Cancer.
- Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells.
- The origin of pre-neoplastic metaplasia in the stomach: Chief cells emerge from the Mist.
- Tests for Serum Levels of Trefoil Factor Family Proteins Can Improve Gastric Cancer Screening.
- AKAP350 is involved in the development of apical "canalicular" structures in hepatic cells HepG2.
- Rab11-FIP2 influences multiple components of the endosomal system in polarized MDCK cells.
- Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.
- Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent.
- Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and shh signaling.
- TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa.
- Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice.
- Mature chief cells are cryptic progenitors for metaplasia in the stomach.
- The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.
- Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer.
- Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking.
- Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer.
- Perspective: Innocence and due diligence: managing unfounded allegations of scientific misconduct.
- Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.
- Efficacy of cetuximab in the treatment of Menetrier's disease.
- D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling.
- Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice.
- Altered gastric chief cell lineage differentiation in histamine-deficient mice.
- The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.
- Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia.
- Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules.
- Alternative splicing in class V myosins determines association with Rab10.
- Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells.
- Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis.
- Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2.
- A molecular signature of gastric metaplasia arising in response to acute parietal cell loss.
- Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori.
- Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells.
- Rab11-FIP2 regulates differentiable steps in transcytosis.
- Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.
- Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling.
- Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice.
- Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer.
- Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia.
- Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation.
- Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma.
- MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells.
- CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25.
- Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy.
- Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation?
- Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777.
- Involvement of myosin Vb in glutamate receptor trafficking.
- Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus.
- Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression.
- Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice.
- Assessment of Rab11-FIP2 interacting proteins in vitro.
- Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system.
- Gastric cancer originating from bone marrow-derived cells.
- Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice.
- AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus.
- Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis.
- Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin.
- Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.
- Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells.
- Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells.
- CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells.
- Differential protein analysis of spasomolytic polypeptide expressing metaplasia using laser capture microdissection and two-dimensional difference gel electrophoresis.
- Differential regulation of CXCR2 trafficking by Rab GTPases.
- Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland.
- Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling.
- Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor.
- AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.
- AKAP350 at the Golgi apparatus. I. Identification of a distinct Golgi apparatus targeting motif in AKAP350.
- Inflammation intersection: gp130 balances gut irritation and stomach cancer.
- Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus.
- Association of spasmolytic polypeptide-expressing metaplasia with carcinogen administration and oxyntic atrophy in rats.
- Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies.
- AKAP350C targets to mitochondria via a novel amphipathic alpha helical domain.
- Distinct patterns of phosphatidylserine localization within the Rab11a-containing recycling system.
Schools
Yale University
Doctors Specialties
- General Surgery
Accepted Insurances
Awards
- Elected Member
Education
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Yale New Haven Children's Center -
Yale University School of Medicine
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