Professor, Medicine, University Massachusetts Medical School
Cardiology
Dr. Jane E. Freedman, MD
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Jane E. Freedman practices Cardiology. She researched medicine at Tufts University School of Medicine. Tufts University School of Medicine is ranked 49 in research and 52 in primary care medicine She received awards:"Elected Member" and "Fellow (FACC)". Jane E. Freedman has written publications. She has 65 publications published with PubMed. The lastest paper is: 'Comparison of RNA Isolation and Associated Methods for Extracellular RNA Detection by High-Throughput qPCR.'
Publications
- Dissecting the Roles of MicroRNAs in Coronary Heart Disease via Integrative Genomic Analyses.
- Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors.
- Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes.
- Platelets: The Unsung Hero of the Immune Response.
- Plasma MicroRNAs are Associated with Atrial Fibrillation and Change after Catheter-ablation (the miRhythm Study).
- Atrial Fibrillation and Stroke Prevention in Aging Patients: What's Good Can be Even Better.
- Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis.
- Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic Disease.
- Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.
- Relations between circulating microRNAs and Atrial fibrillation: Data from the Framingham Offspring Study.
- Sex- and age-interacting eQTLs in human complex Diseases.
- New paradigms in thrombosis: novel mediators and biomarkers platelet RNA transfer.
- Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular Disease and blood phenotypes.
- Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction.
- Relationship Among Circulating Inflammatory Proteins, Platelet Gene Expression, and Cardiovascular Risk.
- Gene expression signatures of Coronary heart disease.
- Defining miRNA Targets: Balancing Simplicity with Complexity.
- Resequencing and Clinical Associations of the 9p21.3 Region: A Comprehensive Investigation in the Framingham Heart Study.
- Appreciating and mitigating bleeding risk.
- A platelet transcriptome revolution.
- Inflammation & the platelet histone trap.
- Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity.
- Regulatory effects of TLR2 on megakaryocytic cell function.
- Relationship Between Markers of Platelet Activation and Inflammation with Disease Activity in Wegener's Granulomatosis.
- The role of the blood transcriptome in innate inflammation and stroke.
- The role of CD40L and VEGF in the modulation of angiogenesis and inflammation.
- Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham Heart study.
- p38: signaling improved platelet storage?
- The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes.
- New therapies for stroke prevention in Atrial fibrillation: the long road to enhanced efficacy.
- Facts and controversies of aspirin and clopidogrel therapy.
- Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase.
- Clopidogrel, genetics, and drug responsiveness.
- Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study.
- Blood and cardiovascular Disease: the promise and limitations of gene expression analysis.
- Aspirin resistance in atherosclerosis.
- Dipyridamole, cerebrovascular Disease, and the vasculature.
- Oxidative stress and platelets.
- Neutrophil CD40 enhances platelet-mediated inflammation.
- Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects.
- CD40-40L signaling in vascular inflammation.
- Heritability, platelet function, and aspirin: a link established but cause unknown.
- The aspirin resistance controversy: clinical entity or platelet heterogeneity?
- Resistance training: does it alter lytic potential?
- Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular Disease.
- CD40 ligand influences platelet release of reactive oxygen intermediates.
- The effect of dipyridamole on vascular cell-derived reactive oxygen species.
- Molecular regulation of platelet-dependent thrombosis.
- Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates.
- Aspirin resistance and atherothrombotic Disease.
- Compensatory mechanisms influence hemostasis in setting of eNOS deficiency.
- The effects of tamoxifen and its metabolites on platelet function and release of reactive oxygen intermediates.
- The antiinflammatory effects of purple grape juice consumption in subjects with stable Coronary artery disease.
- Aspirin resistance: current concepts.
- Regulation of endogenous reactive oxygen species in platelets can reverse aggregation.
- Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release.
- High-fat diets and cardiovascular Disease: are nutritional supplements useful?
- CD40-CD40L and platelet function: beyond hemostasis.
- CD40 ligand--assessing risk instead of damage?
- Nitrated lipids: defining their bioactivity.
- Platelet-monocyte aggregates: bridging thrombosis and inflammation.
- Genome-wide identification of microRNA expression quantitative trait loci.
- Comparison of RNA Isolation and Associated Methods for Extracellular RNA Detection by High-Throughput qPCR.
- Blood-Derived Extracellular RNA and Platelet Pathobiology: Adding Pieces to a Complex Circulating Puzzle.
Schools
Tufts University
Mass Gen Hospital
Brigham and Women39s Hospital
Procedures Preformed
- Cardiac Imaging
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomegaly
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Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACC)
Education
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Brigham and Women's Hospital -
Massachusetts General Hospital -
Tufts University School of Medicine
Hospital
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UMass Memorial Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1881670859 |
| Last Name Of The Provider | FREEDMAN |
| First Name Of The Provider | JANE |
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