Physician
Rheumatology
Dr. Jane H. Buckner, MD
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Jane Buckner works in the field of Rheumatology. She attended Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical university. Johns Hopkins University School of Medicine is ranked 3 in research and 29 in primary care medicine She received 10 awards: "Regional Top Doctor", "CMS Meaningful Use Stage 1 Certification", "American College of Rheumatology Arthritis Investigator Award", "Arthritis Foundation Postdoctoral Fellowship", "Carleton College Dean's List", "Sigma Xi", "Phi Beta Kappa", "National Merit Scholar", "Fellow (FACR)" and "Fellow". Jane Buckner is also a published physician. She has 70 paper published. The most recent paper is: Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T... Doctor Jane H. Buckner, MD accepts Medicare payments and is listed with Medicare.gov.
Publications
- CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.
- Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.
- The Role of PTPN22 Risk Variant in the Development of Autoimmunity: Finding Common Ground between Mouse and Human.
- Cutting Edge: Genetic Variation in TLR1 Is Associated with Pam3CSK4-Induced Effector T Cell Resistance to Regulatory T Cell Suppression.
- Citrulline specific Th1 cells are increased in rheumatoid Arthritis and their frequency is influenced by disease duration and therapy.
- Relatives without rheumatoid Arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with Arthritis-related traits: studies of t...
- Intersection between genetic polymorphisms and immune deviation in type 1 diabetes.
- Increased levels of invariant natural killer T lymphocytes worsens metabolic abnormalities and atheroSclerosis in obese mice.
- Multiple cytokines and chemokines are associated with rheumatoid Arthritis-related autoimmunity in first-degree relatives without rheumatoid Arthritis: Studies of the ...
- Cutting Edge: A Novel, Human-Specific Interacting Protein Couples FOXP3 to a Chromatin-Remodeling Complex That Contains KAP1/TRIM28.
- Anti-cyclic citrullinated peptide assays differ in subjects at elevated risk for rheumatoid Arthritis and subjects with established disease.
- Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA.
- IL-2 therapy in type 1 diabetes: "Trials" and tribulations.
- In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6-Mediated Signaling.
- Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory Cells.
- A functional framework for interpretation of genetic associations in T1D.
- Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function.
- Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant.
- CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game.
- Low-Dose Antigen Promotes Induction of FOXP3 in Human CD4+ T Cells.
- The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B Cells in humans.
- Identification and functional characterization of T Cells reactive to citrullinated-vimentin in HLA-DRB1*0401 humanized mice and RA patients.
- Assessment of suppressive capacity by human regulatory T Cells using a reproducible, bi-directional CFSE-based in vitro assay.
- HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets.
- Complement receptor 2/CD21- human naive B Cells contain mostly autoreactive unresponsive clones.
- Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-Cells of type 1 diabetic subjects.
- A prospective approach to investigating the natural history of preclinical rheumatoid Arthritis (RA) using first-degree relatives of probands with RA.
- Intact extraCellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T Cells.
- CD44 costimulation promotes FoxP3+ regulatory T Cell persistence and function via production of IL-2, IL-10, and TGF-beta.
- Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B Cell signaling.
- The effector T Cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T Cells.
- Functional analysis of FOXP3.
- Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with Scleroderma.
- Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.
- T Cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activity.
- Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T Cells.
- A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.
- De novo generation of antigen-specific CD4+CD25+ regulatory T Cells from human CD4+CD25- Cells.
- Novel APC-like properties of human NK Cells directly regulate T Cell activation.
- Optimization of human T-Cell expansion ex vivo using magnetic beads conjugated with anti-CD3 and Anti-CD28 antibodies.
- Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T Cells.
- Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ Cells with similar TCR avidity.
- Defining antigen-specific responses with human MHC class II tetramers.
- Genetics of rheumatoid Arthritis: is there a scientific explanation for the human leukocyte antigen association?
- Transcript array analysis in rheumatology.
- Identification of type II collagen peptide 261-273-specific T Cell clones in a patient with relapsing polychondritis.
- HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T Cells.
- Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4(+)CD25(hi) T Cells of Type 1 Diabetic and Multiple Sclerosis Patients.
- Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T Cells in human autoimmune diseases.
- Lineage and signal strength determine the inhibitory effect of transforming growth factor beta1 (TGF-beta1) on human antigen-specific Th1 and Th2 memory Cells.
- Mice expressing HLA-DQ6alpha8beta transgenes develop polychondritis spontaneously.
- Plasma 25,OH vitamin D concentrations are not associated with rheumatoid Arthritis (RA)-related autoantibodies in individuals at elevated risk for RA.
- FOXP3 and the regulation of Treg/Th17 differentiation.
- Influence of FOXP3 on CD4+CD25+ regulatory T Cells.
- Functional islet-specific Treg can be generated from CD4+CD25- T Cells of healthy and type 1 diabetic subjects.
- Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T Cells.
- The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T Cells.
- Regulating the immune system: the induction of regulatory T Cells in the periphery.
- Use of class II tetramers for identification of CD4+ T Cells.
- Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions.
- Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.
- T Cell selection and differential activation on structurally related HLA-DR4 ligands.
- Autoreactivity against matrilin-1 in a patient with relapsing polychondritis.
- An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T Cells.
- Immunity to T Cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T...
- Ethnic differences of polymorphism of an immunoglobulin VH3 gene.
- Ethnic differences in VH gene polymorphism.
- Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid Arthritis:...
- Associations of smoking and age with inflammatory joint signs among first-degree relatives without rheumatoid Arthritis: Results from the Studies of the Etiology of RA.
Schools
Johns Hopkins University School Of Medicine
Minneapolis Veterans Hospital
University Of Minnesota Medical Center Fairview
University Of Washington Medical Center
Procedures Preformed
- Joint Drainage
- Steroid Injection
Conditions Treated
- Ankylosing Spondylitis
- Antiphospholipid Syndrome (APS)
- Arthritis
- Bursitis
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Doctors Specialties
- Rheumatology
Accepted Insurances
Awards
- Regional Top Doctor
- CMS Meaningful Use Stage 1 Certification
- American College of Rheumatology Arthritis Investigator Award
- Arthritis Foundation Postdoctoral Fellowship
- Carleton College Dean's List
- Sigma Xi
- Phi Beta Kappa
- National Merit Scholar
- Fellow (FACR)
- Fellow
Education
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University of Minnesota -
Johns Hopkins University School of Medicine
Hospital
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Virginia Mason Medical Center
Drug Facts
| NPI NUMBER | 1740399872 | |
| NPPES Provider LastName | BUCKNER | |
| NPPES Provider FirstName | JANE | |
| NPPES Provider ZIPCode | 981012756 | |
| NPPES Provider State | WA | |
| Specialty Description | Rheumatology | |
| Total Claim Count | 331.0 | |
| Distinct Opioid Count | 2.0 | |
| Opioid Claim Count | 65.0 | |
| Percent Opioid Claims | 19.64 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1740399872 |
| Last Name Of The Provider | BUCKNER |
| First Name Of The Provider | JANE |
| View All |
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