Executive Medical Director Medical Sciences, Amgen; Emeritus Faculty, Academic Council, Medicine - Immunology and Rheumatology, Stanford University Medical Center
Rheumatology
Dr. Jane R. Parnes, MD
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Jane R. Parnes, MD practices Rheumatology. She studied medicine at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1 in research and 12 in primary care medicine She received 1 awards: "Elected Member". Jane Parnes is a published doctor. She has 97 publications published. The most current publication "Regulation of mouse CD72 gene expression during B lymphocyte development."
Publications
- Effects of an anti-TSLP antibody on allergen-induced asthmatic responses.
- CD6 attenuates early and late signaling events, setting thresholds for T-cell activation.
- Modulation of peripheral B cell tolerance by CD72 in a murine model.
- Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse.
- Medicine on a need-to-know basis.
- A unique CD72 epitope suggests a potential interaction with Fc gamma RII/CD32 on B lineage lymphocytes.
- CD72 down-modulates BCR-induced signal transduction and diminishes survival in primary mature B lymphocytes.
- Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.
- OX52 is the rat homologue of CD6: evidence for an effector function in the regulation of CD5 phosphorylation.
- Transfection of the CD8 gene enhances T-cell recognition.
- CD31 mismatching affects marrow transplantation outcome.
- The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice.
- Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.
- CD72, a negative regulator of B-cell responsiveness.
- CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation.
- Regulation of mouse CD72 gene expression during B lymphocyte development.
- Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic develop...
- T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA.
- Mechanisms of CD8beta-mediated T cell response enhancement: interaction with MHC class I/beta2-microglobulin and functional coupling to TCR/CD3.
- The level of CD4 surface protein influences T cell selection in the thymus.
- PU.1/Spi-1 is essential for the B cell-specific activity of the mouse CD72 promoter.
- The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production.
- Specific demethylation of the CD4 gene during CD4 T lymphocyte differentiation.
- Allele-specific expression of the mouse B-cell surface protein CD72 on T cells.
- Molecular linkage of the mouse CD5 and CD6 genes.
- Chromosomal mapping of the second human CD8B gene locus.
- Role of CD4 and CD8 in T cell activation and differentiation.
- Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72.
- Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells.
- The CD8 alpha locus is located on the telomere side of the immunoglobulin kappa locus at a distance of 2 Mb.
- CD4 and CD8 in T cell lineage commitment: alterations induced by expression of a CD8/CD4 chimeric transgene.
- Structure of the mouse CD72 (Lyb-2) gene and its alternatively spliced transcripts.
- Isolation of P1 bacteriophage clones containing large contiguous segments of the human and mouse loci for the T-cell coreceptor molecule CD8.
- CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.
- Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA.
- Human CD6 possesses a large, alternatively spliced cytoplasmic domain.
- Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.
- Transcriptional control of HLA-A,B,C antigen in human placental cytotrophoblast isolated using trophoblast- and HLA-specific monoclonal antibodies and the fluorescence...
- Limitation of differential expression of HLA-A,B,C antigens on choriocarcinoma cell lines by messenger RNA for HLA heavy chain but not by beta 2-microglobulin.
- Control of H-2 antigen and beta 2-microglobulin gene expression in mouse trophoblast cell clones.
- Linkage of beta 2-microglobulin and ly-m11 by molecular cloning and DNA-mediated gene transfer.
- Multiple mRNA species with distinct 3'' termini are transcribed from the beta 2-microglobulin gene.
- Structure of wild-type and mutant mouse beta 2-microglobulin genes.
- Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells.
- Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs.
- Unidirectional transport activity mediated by the galactose-binding protein of Escherichia coli.
- Energy coupling of the -methylgalactoside transport system of Escherichia coli.
- Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone.
- Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.
- Coordinate induction of Ia alpha, beta, and Ii mRNA in a macrophage cell line.
- Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.
- The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.
- A mutational hot-spot within an intron of the mouse beta 2-microglobulin gene.
- Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene.
- L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system.
- Rescue of Daudi cell HLA expression by transfection of the mouse beta 2-microglobulin gene.
- A second chain of human CD8 is expressed on peripheral blood lymphocytes.
- A CD8 polypeptide that is lost after passing the Golgi but before reaching the cell surface: a novel sorting mechanism.
- Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.
- The gene encoding the mouse T cell differentiation antigen L3T4 is located on chromosome 6.
- T-cell differentiation antigens: proteins, genes and function.
- Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain.
- Genes encoding T-cell antigens.
- Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma.
- Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes.
- Mapping of the Ly-4 (L3T4) T-cell differentiation antigen on mouse chromosome 6 by the use of RFLPs in an interspecific cross.
- Structure of the mouse gene encoding CD4 and an unusual transcript in brain.
- Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma.
- Sequence of the Lyb-2 B-cell differentiation antigen defines a gene superfamily of receptors with inverted membrane orientation.
- Role of CD4 and CD8 in enhancing T-cell responses to antigen.
- Inability of CD8 alpha'' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.
- Molecular biology and function of CD4 and CD8.
- Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA.
- Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9.
- The roles of CD4 and CD8 in T cell activation.
- Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity.
- The B-cell surface protein CD72/Lyb-2 is the ligand for CD5.
- Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
- Induction of tolerance in peripheral T cells with monoclonal antibodies.
- Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb-2/CD72.
- An immunological role for the CD8 beta-chain.
- Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail.
- Alteration of T cell lineage commitment by expression of a hybrid CD8/CD4 transgene.
- Polymorphic specificity of Q1/28, a monoclonal antibody that preferentially reacts with free class I heavy chains.
- Human Lyb-2 homolog CD72 is a marker for progenitor B-cell leukemias.
- The T/B cell antigen, CD5, and the B-cell surface protein, CD72, form a pair of interacting receptors.
- Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72).
- Transport alterations in virus-transformed cells.
- [Amino acid transport by membrane vesicles of virally transformed and nontransformed cells: effects of sodium gradient and cell density].
- Sodium-stimulated amino acid uptake into isolated membrane vesicles from Balb/c 3T3 cells transformed by simian virus 40.
- Role of Na+ in alpha-aminoisobutyric acid uptake by membrane vesicles from mouse fibroblasts transformed by simian virus 40.
- CD6: expression during development, apoptosis and selection of human and mouse thymocytes.
- Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.
- Mouse splenic B lymphocyte activation using different activation stimuli induces in vitro splicing of tumor necrosis factor-alpha nuclear pre-mRNA.
- Dual regulation of BCR-mediated growth inhibition signaling by CD72.
- Woodchuck interleukin-6 gene: structure, characterization, and biologic activity.
Schools
Harvard Medical School
Massachusetts General Hospital
Doctors Specialties
- Internal Medicine
- Rheumatology
Accepted Insurances
Awards
- Elected Member
Education
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Massachusetts General Hospital -
Harvard Medical School
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