Professor/Academic
Gastroenterology
Dr. Jay D. Horton, MD
|
|
Give Review
Doctor Jay D. Horton, MD works in the field of Gastroenterology. He researched medicine at University of Iowa Carver College of Medicine. University of Iowa Carver College of Medicine has a rank of 29 in research and a 16 in primary care He received 2 awards: "Fellow (FACP)" and "Elected Member". Jay D. Horton, MD has written publications. He has 57 publications published with PubMed. The lastest paper is: 'Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.' Horton is registered with Medicare and accepts Medicare payments.
Publications
- Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.
- MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
- Acetate dependence of tumors.
- A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice.
- Deletion of ELOVL6 Blocks the Synthesis of Oleic Acid but does not Prevent the Development of Fatty Liver or Insulin Resistance.
- An acetate switch regulates stress erythropoiesis.
- Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
- Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy ...
- Metabolic Response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model.
- The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism.
- Enhanced Fatty Acid Flux Triggered by Adiponectin Overexpression.
- Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people.
- Human AGPAT isoforms 1 and 2: Biochemical characterization and their inability to rescue hepatic steatosis in Agpat2-/- lipodystrophic mice.
- Human fatty liver Disease: old questions and new insights.
- Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression.
- Crystal structure of Spot 14, a modulator of fatty acid synthesis.
- Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans.
- Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.
- Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.
- Genetic and metabolic determinants of plasma PCSK9 levels.
- Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells.
- PCSK9: a convertase that coordinates LDL catabolism.
- Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
- Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.
- Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
- Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.
- Physiology. Unfolding lipid metabolism.
- Plasma PCSK9 preferentially reduces liver LDL receptors in mice.
- Molecular basis for LDL receptor recognition by PCSK9.
- Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells.
- Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and ...
- Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.
- Molecular characterization of Loss-of-function mutations in PCSK9 and identification of a compound heterozygote.
- Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C Disease.
- Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
- Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.
- LXRs regulate the balance between fat storage and oxidation.
- Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.
- Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.
- Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.
- Molecular mediators of hepatic steatosis and liver injury.
- Deficiency of carbohydrate Response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.
- Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
- ATP-citrate lyase deficiency in the mouse.
- Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
- Gallstone Disease and its complications.
- Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.
- Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.
- Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.
- Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.
- SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
- Diminished hepatic Response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.
- Opening up new fronts in the fight against cholesterol.
- Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway.
- Molecular biology of PCSK9: its role in LDL metabolism.
- WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data.
Schools
University of Ia Roy J amp L Carver Com
University Tex Sw Mc
Procedures Preformed
- Anoscopy
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
Conditions Treated
- Abdominal Pain
- Anemia
- Barrett's Esophagus
- Benign Neoplasm of the Digestive System
- View All
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Fellow (FACP)
- Elected Member
Education
-
University of Texas Southwestern Medical School -
University of Iowa Carver College of Medicine
Hospital
-
University of Texas Southwestern Medical Center
Drug Facts
| NPI NUMBER | 1104866458 | |
| NPPES Provider LastName | HORTON | |
| NPPES Provider FirstName | JAY | |
| NPPES Provider ZIPCode | 753907208 | |
| NPPES Provider State | TX | |
| Specialty Description | Internal Medicine | |
| Total Claim Count | 36.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1104866458 |
| Last Name Of The Provider | HORTON |
| First Name Of The Provider | JAY |
| View All |
Similar Doctors
|
|
Dr. Christopher J. Vesy, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Jeffrey S. Weinstein, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Michael Nunez, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. James S. Burdick, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Prabhakar Swaroop, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Gerald M. Isbell III, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Armond G. Schwartz, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Blair Conner, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Robert P. Perrillo, MD
This Doctor is OpenDoctor Recommended.
 This doctor has more publications
|
|
|
Dr. Maria R. Lepe-Suastegui, MD |
|
|
Dr. Walter Young, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Lawrence R. Schiller, MD
This Doctor is OpenDoctor Recommended.
This doctor has more publications
|
|
|
Dr. Christian A. Mayorga Jr., MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Marlyn J. Mayo, MD
This Doctor is OpenDoctor Recommended.
|