Physician
Endocrinology
Dr. Jean L. Chan, MD
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Jean Chan practices Endocrinology. She studied medicine at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is one of the top medical schools in the US. Johns Hopkins University School of Medicine is ranked 3 in research and 29 in primary care medicine Dr. Jean L. Chan is a published doctor and has 34 publications published. The lastest was: 'Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.'
Publications
- Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.
- The clinical approach to the detection of lipodystrophy - an aace consensus statement.
- Clinical Effects of Long-Term Metreleptin Treatment in Patients with Lipodystrophy.
- Clinical classification and treatment of congenital and acquired lipodystrophy.
- Rationale for leptin-replacement therapy for severe lipodystrophy.
- Effect of valsartan on left ventricular anatomy and systolic function and aortic elasticity.
- Management of the metabolic syndrome and type 2 diabetes through lifestyle modification.
- Parathyroid carcinoma and neurofibromatosis.
- Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states.
- Leptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide: interventional studies in humans.
- Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentration-dependent parameters according to assay.
- Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome i...
- Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans.
- Peptide YY levels are elevated after gastric bypass surgery.
- Circulating resistin levels are not associated with fat redistribution, insulin resistance, or metabolic profile in patients with the highly active antiretroviral ther...
- Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo ...
- Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in h...
- Circulating melanin-concentrating hormone, agouti-related protein, and alpha-melanocyte-stimulating hormone levels in relation to body composition: alterations in resp...
- Recombinant human leptin in women with hypothalamic amenorrhea.
- Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects.
- Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional ...
- Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in...
- Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns.
- The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.
- Pharmacological management of type 2 diabetes mellitus: rationale for rational use of insulin.
- Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans.
- Leptin and reproduction: a review.
- It takes two to tango: combined amylin/leptin agonism as a potential approach to obesity drug development.
- Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity.
- r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding pr...
- Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans.
- Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa.
- Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis.
Schools
Johns Hopkins University School of Medicine
Beth Israel Deaconess Med Center
Conditions Treated
- Hypothyroidism
Doctors Specialties
- Endocrinology
Accepted Insurances
Education
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Beth Israel Deaconess Medical Center -
Johns Hopkins University School of Medicine
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