Associate Professor of Pathology, Brigham and Women's Hospital
Pathology
Dr. Jeffery L. Kutok, MD
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Doctor Jeffery L. Kutok, MD works in the field of Pathology. He graduated from Stony Brook University School of Medicine. Jeffery Kutok is a published physician. He has 100 publications published. The most current publication "Intravenous pegylated asparaginase versus intramuscular native Escherichia colil-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001):..."
Publications
- Intravenous pegylated asparaginase versus intramuscular native Escherichia colil-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001):...
- PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models.
- Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia.
- Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.
- A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease.
- Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma.
- Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
- Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis.
- Molecular ontogeny of donor-derived follicular lymphomas occurring after hematopoietic cell transplantation.
- Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer.
- Emerging Targeted Therapies for Lymphoid Malignancies.
- ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia.
- Aberrant Expression of the Dendritic Cell Marker TNFAIP2 by the Malignant Cells of Hodgkin Lymphoma and Primary Mediastinal Large B-Cell Lymphoma Distinguishes These T...
- MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia.
- Strategies for H-score normalization of preanalytical technical variables with potential utility to immunohistochemical-based biomarker quantitation in therapeutic rep...
- Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders.
- Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
- Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.
- Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.
- Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma an...
- T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
- Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma.
- Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
- Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.
- The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
- MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.
- Serologic markers of effective tumor immunity against chronic lymphocytic leukemia include nonmutated B-cell antigens.
- Epstein-barr virus-associated diffuse large B-cell lymphoma in an immunocompetent woman.
- DNA variants in region for noncoding interfering transcript of dihydrofolate reductase gene and outcome in childhood acute lymphoblastic leukemia.
- Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.
- No evidence for the JAK2 (V617F) or JAK2 exon 12 mutations in primary mediastinal large B-cell lymphoma.
- Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors.
- Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
- Matrix metalloproteinases in the urine and tissue of patients with juvenile polyps: potential biomarkers for the presence of polyps.
- H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
- NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract.
- AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features.
- SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma.
- Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.
- Alu elements mediate MYB gene tandem duplication in human T-ALL.
- The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma.
- JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in h...
- B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.
- Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers.
- Epstein-Barr virus thymidine kinase is a centrosomal resident precisely localized to the periphery of centrioles.
- Effects of RAS on the genesis of embryonal rhabdomyosarcoma.
- Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.
- Lymphomas can develop from B cells chronically helped by idiotype-specific T cells.
- Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.
- Regulation of the germinal center response by microRNA-155.
- Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphoma.
- A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
- Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H).
- Mantle cell lymphoma arising within primary nodal marginal zone lymphoma: a unique presentation of two uncommon B-cell lymphoproliferative disorders.
- Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.
- BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammato...
- FAS death domain deletions and cellular FADD-like interleukin 1beta converting enzyme inhibitory protein (long) overexpression: alternative mechanisms for deregulating...
- CD52 is expressed on human mast cells and is a potential therapeutic target in Waldenstrom's Macroglobulinemia and mast cell disorders.
- Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.
- Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma.
- Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
- Evidence for ineffective erythropoiesis in severe sickle cell disease.
- Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population.
- A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.
- NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.
- A SCID-hu in vivo model of human Waldenström macroglobulinemia.
- The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer pati...
- Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.
- Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells.
- Graft-versus-leukemia target antigens in chronic myelogenous leukemia are expressed on myeloid progenitor cells.
- Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.
- Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.
- Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.
- TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar...
- Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.
- tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
- Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.
- Midline carcinoma of children and young adults with NUT rearrangement.
- Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish.
- PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.
- JAGGED1 expression is associated with prostate cancer metastasis and recurrence.
- The pu.1 promoter drives myeloid gene expression in zebrafish.
- Experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for Epstein-Barr virus pathogenesis in the immunosuppressed host.
- TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.
- Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.
- Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin.
- Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.
- Positive and negative regulatory roles of the WW-like domain in TEL-PDGFbetaR transformation.
- Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.
- In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.
- 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.
- Molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques.
- B cell receptor signal strength determines B cell fate.
- Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.
- The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymph...
- Bad-deficient mice develop diffuse large B cell lymphoma.
- Langerhans cell histiocytosis involving the thymus. A case report and review of the literature.
- The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.
- PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRalpha-induced myeloproliferative disease.
Schools
Stony Brook Univ Health Sciences Center School Of Medicine
Brigham and Womens Hospital
Doctors Specialties
- Hematology
- Hematopathology
- Pathology
Accepted Insurances
Education
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Brigham and Women's Hospital -
Stony Brook University School of Medicine
Hospital
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Brigham and Women's Hospital
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