Professor, Pediatrics, Case Western Reserve University School of Medicine
Pediatric Hematology & Oncology
Dr. John J. Letterio, MD
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John J. Letterio, MD practices Pediatric Hematology & Oncology. He researched medicine at The Ohio State University College of Medicine. He over the years received 1 awards: "Regional Top Doctor". John Letterio is a published MD. He has 93 publications published. The most current publication "A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity."
Publications
- The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region.
- Alex's Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011.
- Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review.
- Bryonolic Acid Transcriptional Control of Anti-inflammatory and Antioxidant Genes in Macrophages in Vitro and in Vivo.
- TRAF6 mediates IL-1β/LPS-induced suppression of TGF-β signaling through its interaction with the type III TGF-β receptor.
- Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis.
- Targeting improves MSC treatment of inflammatory bowel disease.
- The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.
- Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages.
- Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
- Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
- The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.
- Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma.
- TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1.
- TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.
- Cutting edge: p27Kip1 deficiency reduces the requirement for CD28-mediated costimulation in naive CD8+ but not CD4+ T lymphocytes.
- IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent.
- p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF-beta-mediated G1 arrest through modulation of IL-2 responsiveness.
- Loss of Smad3 in acute T-cell lymphoblastic leukemia.
- CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.
- Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta.
- Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumo...
- Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells.
- Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis.
- CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.
- Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects.
- Disruption of transforming growth factor beta signaling by a novel ligand-dependent mechanism.
- Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer.
- Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal.
- Disruption of smad4 expression in T cells leads to IgA nephropathy-like manifestations.
- TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2.
- Identification and expression of mouse Langerin (CD207) in dendritic cells.
- Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors.
- Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO.
- Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.
- Smad-dependent cooperative regulation of interleukin 2 receptor alpha chain gene expression by T cell receptor and transforming growth factor-beta.
- 1 alpha, 25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) modulation of insulin-like growth factor-binding protein-3 and induction of differentia...
- Increased mortality, blunted production of nitric oxide, and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic mice.
- Histologic and biochemical correlates of left ventricular chamber dynamics in man.
- TGF-beta1 is essential for the homeostasis of the dentin-pulp complex.
- The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis.
- Autocrine Transforming Growth Factor-beta Growth Pathway in Murine Osteosarcoma Cell Lines Associated with Inability to Affect Phosphorylation of Retinoblastoma Protein.
- Invasive candidiasis stimulates hepatocyte and monocyte production of active transforming growth factor beta.
- The Smad3 protein is involved in TGF-beta inhibition of class II transactivator and class II MHC expression.
- TGF-beta1 null mutation leads to CD154 upregulated expression in affected tissues.
- Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells.
- Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.
- Incisional wound healing in transforming growth factor-beta1 null mice.
- Murine models define the role of TGF-beta as a master regulator of immune cell function.
- Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.
- Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta.
- A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.
- Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer.
- Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.
- Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regula...
- Cytokines may prove useful in the treatment of Sjögrens syndrome (SS) dry eye.
- Regulation of immune responses by TGF-beta.
- TGF-beta knockout and dominant-negative receptor transgenic mice.
- Agrobacterium radiobacter bacteremia in a child with human immunodeficiency virus infection.
- Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
- Consistent loss of functional transforming growth factor beta receptor expression in murine plasmacytomas.
- Langerhans cells in the TGF beta 1 null mouse.
- TGF-beta: a critical modulator of immune cell function.
- A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice.
- Up-regulation of cytokine mRNA, adhesion molecule proteins, and MHC class II proteins in salivary glands of TGF-beta1 knockout mice: MHC class II is a factor in the pa...
- Biology of TGF-beta in knockout and transgenic mouse models.
- A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Lang...
- Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.
- The liver in transforming growth factor-Beta-1 (TGF-beta 1) null mutant mice.
- Role of laminin-1 and TGF-beta 3 in acinar differentiation of a human submandibular gland cell line (HSG).
- Control of nitric oxide production by endogenous TGF-beta1 and systemic nitric oxide in retinal pigment epithelial cells and peritoneal macrophages.
- Transforming growth factor-beta1-deficient mice: identification of isoform-specific activities in vivo.
- Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null...
- Transforming growth factor-beta s in mammary tumorigenesis: promoters or antipromoters?
- Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expres...
- Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta.
- 1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat.
- Maternal rescue of transforming growth factor-beta 1 null mice.
- Induction of transforming growth factor beta 1 and its receptors during all-trans-retinoic acid (RA) treatment of RA-responsive human neuroblastoma cell lines.
- SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.
- Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin.
- Function of cytokines within the TGF-beta superfamily as determined from transgenic and gene knockout studies in mice.
- Development and application of fully functional epitope-tagged forms of transforming growth factor-beta.
- Differential regulation of mouse B cell development by transforming growth factor beta1.
- Disruption of the TGF-beta pathway and modeling human cancer in mice.
- TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.
- TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia.
- Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally.
- Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.
- Concentration-dependent bifunctional effect of TGF-beta 1 on immunoglobulin production: a role for Smad3 in IgA production in vitro.
- TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent.
- Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.
Schools
Oh State Univ Coll Of Med and Pub Hlth
Doctors Specialties
- Pediatrics
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Regional Top Doctor
Education
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Case Western Reserve University - University Hospitals -
The Ohio State University College of Medicine
Hospital
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University Hospitals Case Medical Center
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