Professor of Medicine, Ohio State University; Chief, Division of Pulmonary, Allergy, Critical Care and Sleep; Director, Critical Care Signature Program OSU-Wexner Medical Center
Internal Medicine
Dr. John W. Christman, MD
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John W. Christman practices Internal Medicine. He went to medical school at Indiana University School of Medicine. Indiana University School of Medicine has a rank of 45 in research and a 47 in primary care He received awards:"Presidents Citation for outstanding contribution to the Society of Critical Care Medicine in 1997.", "The Harry L. Davis, M.D. Memorial Award in recognition of outstanding achievement in the field of pulmonary medicine.", "Career Development Award, Research Associate", "Phi Beta Kappa", "Sophomore Chemistry Award" and "Super Doctor". Doctor John W. Christman, MD is a published MD. He published 102 publications, including: 'A sensible approach to the nutritional support of mechanically ventilated critically ill patients.' He is registered with Medicare and accepts Medicare payments.
Publications
- Suppression of Von Hippel-Lindau Protein in Fibroblasts Protects Against Bleomycin-induced Pulmonary Fibrosis.
- p47phox and reactive oxygen species production modulate expression of microRNA-451 in macrophages.
- Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: implication in hyperglycemia.
- Recruited Alveolar Macrophages, in Response to Airway Epithelial-derived MCP-1/CCL2, Regulate Airway Inflammation and Remodeling in Allergic Asthma.
- Differential Role for p120-Catenin in Regulation of TLR4 Signaling in Macrophages.
- The Transcription Factor Nuclear Factor of Activated T Cells c3 Modulates the Function of Macrophages in Sepsis.
- The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation.
- Autotaxinproduction of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation.
- The Novel Role of IL-7 Ligation to IL-7 Receptor in Myeloid Cells of Rheumatoid Arthritis and Collagen-Induced Arthritis.
- Method development and validation for ultra-high pressure liquid chromatography/tandem mass spectrometry determination of multiple prostanoids in biological samples.
- Pivotal role of reactive oxygen species in differential regulation of lipopolysaccharide-induced prostaglandins production in macrophages.
- Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE(2) Production in Bone Marrow Derived Macrophages.
- Protective Role of Reactive Oxygen Species in Endotoxin-Induced Lung Inflammation through Modulation of IL-10 Expression.
- Dangkwisoo-san, an herbal medicinal formula, ameliorates acute Lung inflammation via activation of Nrf2 and suppression of NF-?B.
- Role for the Guanine Nucleotide Exchange Factor Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchanger 1 in Platelet Secretion and Aggregation.
- Local Delivery of GM-CSF Protects Mice from Lethal Pneumococcal Pneumonia.
- Functional PU.1 in macrophages has a pivotal role in NF-{kappa}B activation and neutrophilic Lung inflammation during endotoxemia.
- Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2.
- ent-kaur-16-en-19-oic acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2.
- Physiology, Reductionism and Translational Medicine: The Right Mix.
- Anthrax Lethal Factor Activates K+ Channels To Induce IL-1{beta} Secretion in Macrophages.
- Is the cellular response to cigarette smoke predictive of the phenotypic variation of COPD?
- Dendritic Cell Depletion and Repopulation in the Lung after Irradiation and Bone Marrow Transplantation in Mice.
- Development of a nomogram for identification of Asthma among adults in epidemiologic studies.
- Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal Lung infection.
- NADPH oxidase limits innate immune responses in the Lungs in mice.
- Prevalence of type 2 diabetes in patients with Obstructive sleep apnea in a multi-ethnic sample.
- NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene.
- Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages.
- Myeloid cells control termination of Lung inflammation through the NF-kappaB pathway.
- Tumor necrosis factor-alpha-mediated suppression of adipocyte apolipoprotein E gene transcription: Primary role for the nuclear factor (NF)-kappaB pathway and NFkappaB...
- Genetic determination of the role of PU.1 in macrophage gene expression.
- An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids.
- Macrophage Turnover Kinetics in the Lungs of Mice Infected with Streptococcus pneumoniae.
- NF-kappaB-inducing kinase regulates cyclooxygenase 2 gene expression in macrophages by phosphorylation of PU.1.
- Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.
- Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages.
- Induction and function of lipocalin prostaglandin D synthase in host immunity.
- E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying Lung injury.
- Airway epithelium controls Lung inflammation and injury through the NF-kappa B pathway.
- Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages.
- Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages.
- Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis.
- Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced Lung inflammation.
- NIK is involved in nucleosomal regulation by enhancing histone H3 phosphorylation by IKKalpha.
- Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung Diseases.
- Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa.
- Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute Lung injury.
- Perspectives, translational research, and letters to the editor.
- PU.1 regulates cathepsin S expression in professional APCs.
- Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia.
- Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta.
- Pathogen-host interactions in Pseudomonas aeruginosa Pneumonia.
- CCR2-positive monocytes recruited to inflamed Lungs downregulate local CCL2 chemokine levels.
- Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation.
- Pneumolysin-induced Lung injury is independent of leukocyte trafficking into the alveolar space.
- Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3.
- Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1.
- p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas Pneumonia.
- Endotoxin potentiates Lung injury in cerulein-induced pancreatitis.
- Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo.
- Monocytes are potent facilitators of alveolar neutrophil emigration during Lung inflammation: role of the CCL2-CCR2 axis.
- Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis.
- Selective I kappa B kinase expression in airway epithelium generates neutrophilic Lung inflammation.
- Modulation of endotoxin-induced NF-kappa B activation in Lung and liver through TNF type 1 and IL-1 receptors.
- Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice.
- Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin.
- Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice.
- Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kappaB activation in a transgenic mouse model.
- Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2.
- Nuclear factor kappa B is a promising therapeutic target in inflammatory lung Disease.
- Endotoxin induced peritonitis elicits monocyte immigration into the Lung: implications on alveolar space inflammatory responsiveness.
- The role of nuclear factor kappa B in the pathogenesis of Pulmonary diseases: implications for therapy.
- Young man with progressive weight loss, fevers, and a hilar mass.
- NF-kappaB: a therapeutic target in inflammatory Diseases.
- Molecular targets for modulating Lung inflammation and injury.
- Fifteen-S-hydroxyeicosatetraenoic acid (15-S-HETE) specifically antagonizes the chemotactic action and glomerular synthesis of leukotriene B4 in the rat.
- Endotoxin induces the expression of macrophage inflammatory protein 1 alpha mRNA by rat alveolar and bone marrow-derived macrophages.
- Potential treatment of sepsis syndrome with cytokine-specific agents.
- Regulation of alveolar macrophage production of chemoattractants by leukotriene B4 and prostaglandin E2.
- Effects of work exposure, retirement, and smoking on bronchoalveolar lavage measurements of Lung dust in Vermont granite workers.
- Analysis of effector cell-derived lyso platelet activating factor by electron capture negative ion mass spectrometry.
- Paradoxical regulation by PGE-2 on release of neutrophil chemoattractants by rat bone marrow macrophages.
- Mechanisms and mediators of the adult Respiratory distress syndrome.
- Rat alveolar macrophage production of chemoattractants for neutrophils: response to Escherichia coli endotoxin.
- Alveolar macrophage function is selectively altered after endotoxemia in rats.
- Raised immunoglobulin concentrations in bronchoalveolar lavage fluid of healthy granite workers.
- Modification by hyperoxia in vivo of endotoxin-induced neutrophil alveolitis in rats. Production of chemotactic factors by alveolar macrophages and ultrastructure.
- Mineral dust and cell recovery from the bronchoalveolar lavage of healthy Vermont granite workers.
- Defining the Lung's response to endotoxin.
- Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells.
- Dysregulated NF-kappaB activation in cystic fibrosis: evidence for a Primary inflammatory disorder.
- High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice.
- Impaired Pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice.
- Practical management of diabetes in critically ill patients.
- Strategies for blocking the systemic effects of cytokines in the sepsis syndrome.
- Cytokine-induced neutrophil chemoattractant mediates neutrophilic alveolitis in rats: association with nuclear factor kappa B activation.
- Leukotriene B4 stimulates human polymorphonuclear leukocytes to synthesize and release interleukin-8 in vitro.
- Regulation of tumor necrosis factor-alpha receptors on macrophages: differences between Primary macrophages and transformed macrophage cell lines.
- A sensible approach to the nutritional support of mechanically ventilated critically ill patients.
- FoxO1 regulates allergic Asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype.
Schools
Indiana University School of Medicine
Indiana University
University Of Pittsburgh
University Vt
Procedures Preformed
- Bronchoscopy
- Thoracentesis
- Ventilation Management
Conditions Treated
- Acidosis
- Asthma
- Atelectasis
- Chronic Pulmonary Heart Diseases (incl. Pulmonary Hypertension)
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Doctors Specialties
- Critical Care Medicine
- Pulmonology
- Internal Medicine
Accepted Insurances
Awards
- President’s Citation for outstanding contribution to the Society of Critical Care Medicine in 1997.
- The Harry L. Davis, M.D. Memorial Award in recognition of outstanding achievement in the field of pulmonary medicine.
- Career Development Award, Research Associate
- Phi Beta Kappa
- Sophomore Chemistry Award
- Super Doctor
Education
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University of Vermont - Fletcher Allen Health Care -
Indiana University School of Medicine -
Indiana University
Hospital
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Ohio State University Wexner Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1720027808 |
| Last Name Of The Provider | CHRISTMAN |
| First Name Of The Provider | JOHN |
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