Physician

Allergy & Immunology

Dr. Jonathan D. Ashwell is an expert in the field of Allergy & Immunology. He over the years received 1 awards: "Whos Who in Medicine and Healthcare". Jonathan Ashwell is a published doctor. He has 37 publications published. The most current publication "Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor."

Publications

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• Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
• Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.
• Counter-regulation of T cell effector function by differentially activated p38.
• Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses.
• Scavenger Receptor BI and High-Density Lipoprotein Regulate Thymocyte Apoptosis in Sepsis.
• A method for high purity sorting of rare cell subsets applied to TDC.
• Optineurin Insufficiency Impairs IRF3 but Not NF-κB Activation in Immune Cells.
• CD70 Is Downregulated by Interaction with CD27.
• CD70 Deficiency Impairs Effector CD8 T Cell Generation and Viral Clearance but Is Dispensable for the Recall Response to Lymphocytic Choriomeningitis Virus.
• Balance between NF-?B p100 and p52 regulates T cell costimulation dependence.
• A20: more than one way to skin a cat.
• Lack of the T-cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.
• Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.
• The CD8+ memory T-cell state of readiness is actively maintained and reversible.
• T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity.
• Structural basis for recognition of diubiquitins by NEMO.
• Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.
• TWEAKing death.
• Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.
• IAPs: what's in a name?
• NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.
• Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation.
• Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling.
• Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.
• Activating p38 MAPK: new tricks for an old kinase.
• Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
• The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
• T cells in G1 provide a memory-like response to secondary stimulation.
• Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo.
• Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis.
• Antigen-driven T cell expansion: affinity rules.
• Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression.
• Regulation of constitutive TCR internalization by the zeta-chain.
• HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.
• Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.
• Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha.

Schools

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• Columbia University College of Physicians And Surgeons

Doctors Specialties

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• Internal Medicine
• Allergy
• Immunology

Accepted Insurances

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Awards

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• Whos Who in Medicine and Healthcare

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