Associate Professor of Medicine, Harvard Medical School
Hematology
Dr. Jose A. Halperin, MD
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Dr. Jose A. Halperin practices Hematology. Doctor Jose A. Halperin, MD is a published physician. He published 62 publications, including: 'Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole.'
Publications
- Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein-Protein Interaction.
- Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.
- 3-Substituted Indazoles as Configurationally Locked 4EGI-1 Mimetics and Inhibitors of the eIF4E/eIF4G Interaction.
- Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase.
- Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAi(Met) ternary complex inhibitors.
- A specific and sensitive assay for blood levels of glycated CD59: A novel biomarker for diabetes.
- Chemical genetics identify eIF2? kinase heme-regulated inhibitor as an anticancer target.
- Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis.
- The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model.
- Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice.
- A high-affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: implications for treatment of HIV-1/AIDS.
- Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice.
- Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex.
- Generation and phenotyping of mCd59a and mCd59b double-knockout mice.
- Side chain-to-side chain cyclization by intramolecular click reaction--building blocks, solid phase synthesis and conformational characterization.
- Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition.
- Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin.
- Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction.
- Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
- Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction.
- Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics.
- Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.
- Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes.
- Translational regulation of gene expression by omega-3 fatty acids.
- 3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition.
- Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility.
- Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation.
- Building blocks for the synthesis of post-translationally modified glycated peptides and proteins.
- Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.
- Synthesis of fluorescein labeled 7-methylguanosinemonophosphate.
- Inhibition of translation initiation mediates the anticancer effect of the n-3 polyunsaturated fatty acid eicosapentaenoic acid.
- Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation.
- Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59.
- Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole.
- Molecular basis for a link between complement and the vascular complications of diabetes.
- Analysis of the promoters and 5''-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes.
- Complement and complement regulatory proteins as potential molecular targets for vascular diseases.
- The transient pore formed by homologous terminal complement complexes functions as a bidirectional route for the transport of autocrine and paracrine signals across hu...
- Transient changes in erythrocyte membrane permeability are induced by sublytic amounts of the complement membrane attack complex (C5b-9).
- Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance.
- Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b.
- Membrane signaling by complement C5b-9, the membrane attack complex.
- Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells.
- Clotrimazole inhibits cell proliferation in vitro and in vivo.
- Ca2+-activated K+ efflux limits complement-mediated lysis of human erythrocytes.
- Glycated-CD59 antigen: exploration of synthetic approaches.
- Activated complement directly modifies the performance of isolated heart muscle cells from guinea pig and rat.
- Complement induces a transient increase in membrane permeability in unlysed erythrocytes.
- Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells.
- Mechanisms by which the erythrocyte protects itself from complement damage.
- Digitalis-like properties of an inhibitor of the Na+/K+ pump in human cerebrospinal fluid.
- Voltage-activated cation permeability in high-potassium but not low-potassium red blood cells.
- A voltage-activated cation transport pathway associated with the sodium pump.
- Voltage-activated cation transport in human erythrocytes.
- Characteristics of an inhibitor of the Na+/K+ pump in human cerebrospinal fluid.
- Characterization of neuronal cell death induced by complement activation.
- Palytoxin induces an increase in the cation conductance of red cells.
- Paroxysmal nocturnal hemoglobinuria. A complement-mediated disease.
- Complement-mediated neurotoxicity is regulated by homologous restriction.
- Recommendations on the use of potassium iodide as a thyroid-blocking agent in radiation accidents: an FDA update.
- Tolerance to the granulocyte-releasing and colony-stimulating factor elevating effects of endotoxin.
Schools
Universidad De Buenos Aires Facultad De Ciencias Medicas
Doctors Specialties
- Internal Medicine
- Hematology
Accepted Insurances
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
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