Professor, Internal Medicine, University of Utah School of Medicine

Internal Medicine

Josef T. Prchal practices Internal Medicine. He received 10 awards: "Molecular Basis of PV (Ph-neg MPNs), Hypoxia and its Relevance to Acute Leukemias", "Honorary Doctor", "Excellence in Research Award 2005", "Chair", "Anniversary Medal of Charles University", "Elected as a member of American Association of Physicians", "Elected to membership of the Association of American Physicians", "Recipient of the American Cancer Society Scholar Award", "Fellow" and "Purkynje' Medal for Medical Student Research". Josef Prchal is a published physician. He published 97 publications, including: 'Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.' Josef Prchal is registered with Medicare and accepts Medicare payments.

Publications

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• Metabolic aspects of high-altitude adaptation in Tibetans.
• Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.
• End-tidal carbon monoxide as an indicator of the hemolytic rate.
• Phase I dose escalation study of lestaurtinib in patients with myelofibrosis.
• Allo-SCT for myelofibrosis: reversing the Chronic phase in the JAK inhibitor era?
• Complications in children and adolescents with Chuvash Polycythemia.
• A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained Anemia and serum ferritin 20-200 ng/mL.
• Novel α-Spectrin Mutation in Trans with α-Spectrin Causing Severe Neonatal Jaundice from Hereditary Spherocytosis.
• Calreticulin mutated prefibrotic-stage myelofibrosis and PMF represent an independent clone from coexisting CLL.
• A genetic mechanism for Tibetan high-altitude adaptation.
• MPD-RC 101 prospective study of reduced intensity allogeneic hematopoietic stem Cell transplantation in patients with myelofibrosis.
• Myelofibrotic Transformations of Polycythemia Vera and Essential Thrombocythemia are Morphologically, Biologically, and Prognostically Indistinguishable From Primary M...
• The homozygous VHL(D126N) missense mutation is associated with dramatically elevated erythropoietin levels, consequent Polycythemia, and early onset severe pulmonary h...
• High altitude genetic adaptation in Tibetans: No role of increased hemoglobin-oxygen affinity.
• The Hypoxic Response Contributes to Altered Gene Expression and Pre-Capillary Pulmonary Hypertension in Patients with Sickle Cell Disease.
• Whole-exome sequencing of polycythemia vera revealed novel driver genes and somatic mutation shared by T Cells and granulocytes.
• The relationship of JAK2(V617F) and acquired UPD at chromosome 9p in Polycythemia vera.
• RUNX1 and NF-E2 upregulation is not specific for MPNs but is seen in polycythemic Disorders with augmented HIF signaling.
• Neonatal Death Suspected To Be From Sepsis Was Found To Be Kernicterus With G6PD Deficiency.
• Detection of Nine Mediterranean β-Thalassemia Mutations in Palestinians Using Three Restriction Enzyme Digest Panels: A Reliable Method for Developing Countries.
• Variations in Both α-Spectrin (SPTA1) and β-Spectrin ( SPTB ) in a Neonate with Prolonged Jaundice in a Family where Nine Individuals Had Hereditary Elliptocytosis.
• Novel compound VHL heterozygosity (VHL T124A/L188V) associated with congenital polycythaemia.
• Differential sensitivity to JAK inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient iPSCs.
• Acute Kernicterus in a Neonate With O/B Blood Group Incompatibility and a Mutation in SLC4A1.
• Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing.
• β-Thalassemia Due to Intronic LINE-1 Insertion in the β-Globin Gene (HBB): Molecular Mechanisms Underlying Reduced Transcript Levels of the β-GlobinL1 Allele.
• Novel homozygous VHL mutation in exon 2 is associated with congenital Polycythemia but not with cancer.
• New Syndrome of paraganglioma and somatostatinoma associated with polycythemia.
• The phenotype of Polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash Polycythemia (VHL 598C>T:R200W).
• Concomitant JAK2 V617F-positive polycythemia vera and B-cell chronic lymphocytic Leukemia in three patients originating from two separate hematopoietic stem cells.
• Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system.
• Could hypoxia increase the prevalence of thrombotic complications in Polycythemia vera?
• A Quantitative Allele-Specific PCR Test for the BRAF V600E Mutation Using a Single Heterozygous Control Plasmid for Quantitation: A Model for qPCR Testing without Stan...
• Novel HIF2A mutations disrupt oxygen sensing leading to Polycythemia, paragangliomas and somatostatinomas.
• Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash Polycythemia: a role for HIF in glucose metabolism.
• Molecular basis of polycythemic disorders due to aberrant hypoxia sensing and its relevance to Acute leukemia.
• A novel EPAS1/HIF2A germline mutation in a congenital Polycythemia with paraganglioma.
• Detection of JAK2 mutations in paraffin marrow biopsies by high resolution melting analysis: identification of L611S alone and in cis with V617F in Polycythemia vera.
• Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Gaza Strip Palestinians.
• Hemolysis and Mediterranean G6PD mutation (c.563 C>T) and c.1311 C>T polymorphism among Palestinians at Gaza Strip.
• Genetic determinants of Tibetan high-altitude adaptation.
• Chuvash Polycythemia VHLR200W mutation is associated with downregulation of hepcidin expression.
• Interferon and PV stem Cells.
• Convergent mechanisms of somatic mutations in Polycythemia vera.
• The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against Anemia.
• Molecular basis of two novel mutations found in type I methemoglobinemia.
• Hypoxia and Hematopoiesis.
• Sickle cell Disease resulting from uniparental disomy in a child who inherited sickle cell trait.
• Genetic evidence for high-altitude adaptation in Tibet.
• JAK2 kinase inhibitors and myeloproliferative Disorders.
• Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo.
• EPO receptor gain-of-function causes hereditary polycythemia, alters CD34 Cell differentiation and increases circulating endothelial precursors.
• Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family.
• Does HUMARA assay for assessment of clonal hematopoiesis have shortcomings?
• Enrichment of Sca1+ hematopoietic progenitors in polycythemic mice inhibits leukemogenesis.
• Plasma quantitation of JAK2 mutation is not suitable as a clinical test: an artifact of storage.
• Erythropoiesis in Polycythemia vera is hyper-proliferative and has accelerated maturation.
• Imatinib mesylate therapy for Polycythemia vera: final result of a phase II study initiated in 2001.
• Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell Disease.
• Concordance of assays designed for the quantification of JAK2V617F: a multicenter study.
• Hematopoiesis is not clonal in healthy elderly women.
• Erythropoietic agents and the elderly.
• Cre recombinase expression controlled by the hematopoietic regulatory domain of Gata-1 is erythroid-specific.
• Does erythropoietin promote tumor growth?
• Revised criteria for the myeloproliferative Disorders: too much too soon?
• Philadelphia chromosome-negative myeloproliferative Disorders: an historical perspective.
• Is congenital secondary erythrocytosis/Polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?
• X-linked clonality testing: interpretation and limitations.
• Endogenous erythropoietin signaling is required for normal neural progenitor Cell proliferation.
• Are erythropoietin receptors expressed in tumors? Facts and fiction--more careful studies are needed.
• Redefining endothelial progenitor Cells via clonal analysis and hematopoietic stem/progenitor Cell principals.
• Genetic mechanisms underlying regulation of hemoglobin mass.
• Philadelphia chromosome-negative myeloproliferative Disorders: biology and treatment.
• Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development.
• DMT1 mutation: response of Anemia to darbepoetin administration and implications for iron homeostasis.
• High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with Myeloid metaplasia from secondary myelofibr...
• Vascular complications in Chuvash Polycythemia.
• JAK2 mutation 1849G>T is rare in Acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
• Chronic myeloproliferative disorders--introduction.
• Lessons from familial myeloproliferative Disorders.
• New onset of myelofibrosis in association with pulmonary arterial hypertension.
• Recent advances in the molecular biology of congenital Polycythemias and Polycythemia vera.
• Polycythemia vera and other primary Polycythemias.
• The constitutive mobilization of bone marrow-repopulating Cells into the peripheral blood in idiopathic myelofibrosis.
• Identification of a human mutation of DMT1 in a patient with microcytic Anemia and iron overload.
• Red Cell enzymes.
• Severe hypochromic microcytic Anemia caused by a congenital defect of the iron transport pathway in erythroid cells.
• Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with Thrombosis and vascular abnormalities but not tumors.
• The worldwide distribution of the VHL 598C>T mutation indicates a single founding event.
• Angiotensin II receptor type 1 expression in erythroid progenitors: Implications for the pathogenesis of postrenal transplant erythrocytosis.
• Oxygen-dependent regulation of erythropoiesis.
• Clonal hematopoiesis in familial polycythemia vera suggests the involvement of multiple mutational events in the early pathogenesis of the Disease.
• Possible primary familial and congenital Polycythemia locus at 7q22.1-7q22.2.
• Classification and molecular biology of Polycythemias (erythrocytoses) and thrombocytosis.
• Search for genetic determinants of individual variability of the erythropoietin response to high altitude.
• Mutations of von Hippel-Lindau tumor-suppressor gene and congenital Polycythemia.

Procedures Preformed

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• Plasmapheresis

Conditions Treated

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• Acute Leukemia
• Anemia
• Antiphospholipid Syndrome (APS)
• Chronic Myeloid Leukemia (CML)
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Doctors Specialties

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• Hematology
• Internal Medicine

Accepted Insurances

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Awards

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• Molecular Basis of PV (Ph-neg MPNs), Hypoxia and its Relevance to Acute Leukemias
• Honorary Doctor
• Excellence in Research Award 2005
• Chair
• Anniversary Medal of Charles University
• Elected as a member of American Association of Physicians
• Elected to membership of the Association of American Physicians
• Recipient of the American Cancer Society Scholar Award
• Fellow
• Purkynje' Medal for Medical Student Research

Education

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• University of Toronto
• Karlovy University

Hospital

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• University of Utah Health Care - Hospital and Clinics

Drug Facts

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NPI NUMBER		1427008341
NPPES Provider LastName		PRCHAL
NPPES Provider FirstName		JOSEF
NPPES Provider ZIPCode		841125500
NPPES Provider State		UT
Specialty Description		Hematology
Total Claim Count		130.0
Distinct Opioid Count		0.0
Opioid Claim Count		0.0
Percent Opioid Claims		0.0

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Medicare Facts

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National Provider Identifier [NPI]	1427008341
Last Name Of The Provider	PRCHAL
First Name Of The Provider	JOSEF
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