Physician
Radiology
Dr. Joseph A. Kozlowski, MD
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Joseph Kozlowski practices Radiology. He studied medicine at Wayne State University School of Medicine. Wayne State University School of Medicine is ranked 63/85 in Research/PrimaryCare. Dr. Joseph A. Kozlowski is a published doctor and has 50 publications published. The lastest was: 'Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.'
Publications
- Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.
- Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate.
- IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: Improved PK, hERG and metabolic profiles.
- The Discovery of N-((2H-Tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzam...
- Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity.
- Discovery of an irreversible HCV NS5B polymerase inhibitor.
- Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmac...
- Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists.
- Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.
- Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors.
- A Novel Class of Highly Potent Irreversible Hepatitis C Virus (HCV) NS5B Polymerase Inhibitors.
- Structure-Activity-Relationship Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus NS5B Polymerase.
- II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides.
- I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles.
- Cannabinoid CB(2)-selective inverse agonist protects against antigen-induced bone loss.
- Characterization of peripheral human cannabinoid receptor (hCB2) expression and pharmacology using a novel radioligand, [35S]Sch225336.
- A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo.
- Synthesis of mono- and difluoronaphthoic acids.
- Muscarinic agonists and antagonists in the treatment of Alzheimer''s disease.
- Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.
- Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788.
- Biology and therapeutic potential of cannabinoid CB2 receptor inverse agonists.
- SCH 57790: a novel M2 receptor selective antagonist.
- CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis.
- Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates.
- SCH 57790, a selective muscarinic M(2) receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals.
- Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor.
- Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.
- Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3'' pocket.
- Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies.
- Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice.
- Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies.
- Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.
- Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine fa...
- Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.
- Optimization of triaryl bis-sulfones as cannabinoid-2 receptor ligands.
- 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.
- II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists.
- Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases.
- Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands.
- Biaryl substituted hydantoin compounds as TACE inhibitors.
- Structure and activity relationships of tartrate-based TACE inhibitors.
- Discovery and SAR of hydantoin TACE inhibitors.
- The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
- Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors.
- Novel CXCR3 antagonists with a piperazinyl-piperidine core.
- Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors.
- Labelling and biological evaluation of [(11)C]methoxy-Sch225336: a radioligand for the cannabinoid-type 2 receptor.
- III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold.
Schools
Wayne State University
Providence Hospital
University Minn Hospital and Clins
University Ky Hospital
Doctors Specialties
- Diagnostic Radiology
- Radiology
Accepted Insurances
- Amerigroup (Wellpoint)
- Commercial Insurance Company
- CoreSource
- Coventry Health Care
- Humana
- Medical Mutual of Ohio
- Medicare MCR
- Molina
- United Healthcare
Education
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University of Minnesota at Fairview -
Providence Hospital and Medical Centers -
Wayne State University School of Medicine
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1588742746 |
| Last Name Of The Provider | KOZLOWSKI |
| First Name Of The Provider | JOSEPH |
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