Chief Medical Officer, Holy Spirit Health System

Internal Medicine

Joseph A. Torchia, MD practices Internal Medicine. He attended St. George's University School of Medicine. Joseph A. Torchia is a published physician as well. He has 40 publications published. The latest was: Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation.

Publications

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• Regulation of the BRCA1 gene by an SRC3/53BP1 complex.
• Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C.
• Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase.
• Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.
• Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.
• Biochemical analysis of arginine methylation in transcription.
• Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex.
• Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3.
• Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence.
• The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation.
• Direct association between the CREB-binding protein (CBP) and nuclear receptor corepressor (N-CoR).
• Food, water, and the PVS patient.
• The coactivator p/CIP/SRC-3 facilitates retinoic acid receptor signaling via recruitment of GCN5.
• Artificial hydration and nutrition for the PVS patient: ordinary care or extraordinary intervention?
• Microtubule-dependent subcellular redistribution of the transcriptional coactivator p/CIP.
• Requirement for RAR-mediated gene repression in skeletal progenitor differentiation.
• Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
• Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex.
• Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription.
• Postmodernism and the persistent vegetative state.
• Isolation of a p300/CBP cointegrator-associated protein coactivator complex.
• A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.
• Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation.
• Co-activators and co-repressors in the integration of transcriptional responses.
• Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.
• Transcription factor-specific requirements for coactivators and their acetyltransferase functions.
• Differential use of CREB binding protein-coactivator complexes.
• The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.
• Mechanisms of transcriptional activation by retinoic acid receptors.
• A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
• A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.
• Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.
• Carbachol-stimulated phosphorylation of the Na-K-Cl cotransporter of avian salt gland. Requirement for Ca2+ and PKC Activation.
• The Na-K-Cl cotransporter of avian salt gland. Phosphorylation in response to cAMP-dependent and calcium-dependent secretogogues.
• Protein kinase C mediated activation and phosphorylation of Ca(2+)-pump in cardiac sarcolemma.
• Endogenous substrates of rat heart protein kinase C type I, II, and III isozymic forms in cardiac sarcolemma.
• Carbachol-stimulated phosphorylation of a 170-kDa endogenous protein in avian salt gland cells.
• Purification and characterization of protein kinase C isozymes from rat heart.
• Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

Doctors Specialties

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• Internal Medicine

Accepted Insurances

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Education

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• St. George's University School of Medicine

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