Physician
Anesthesiology
Dr. Joseph M. Jez, MD
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Joseph is an expert in the field of Anesthesiology. He studied medicine at University of Texas Southwestern Medical School. Joseph is a published doctor and has 94 publications published. The lastest was: 'Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase.'
Publications
- An Alternate Mechanism for the Methylation of Phosphoethanolamine Catalyzed by Plasmodium falciparum Phosphoethanolamine Methyltransferase.
- Structural Evolution of Differential Amino Acid Effector Regulation in Plant Chorismate Mutases.
- Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression.
- Structural basis for regulation of rhizobial nodulation and symbiosis gene expression by the regulatory protein NolR.
- Nematode phospholipid metabolism: an example of closing the genome-structure-function circle.
- Structure and Mechanism of Soybean ATP Sulfurylase and the Committed Step in Plant Sulfur Assimilation.
- Immunolocalization of glutathione biosynthesis enzymes in Arabidopsis thaliana.
- Toxicological evaluation of proteins introduced into food crops.
- Evolution of Structure and Mechanistic Divergence in Di-Domain Methyltransferases from Nematode Phosphocholine Biosynthesis.
- Enzyme Action in the Regulation of Plant Hormone Responses.
- The cysteine regulatory complex from plants and microbes: what was old is new again.
- Probing the origins of glutathione biosynthesis through biochemical analysis of glutamate-cysteine ligase and glutathione synthetase from a model photosynthetic prokar...
- Redox-Linked Gating of Nucleotide Binding by the N-Terminal Domain of Adenosine 5'-Phosphosulfate Kinase.
- Structural basis and evolution of redox regulation in plant adenosine-5'-phosphosulfate kinase.
- Structural and Kinetic Analysis of the Unnatural Fusion Protein 4-Coumaroyl-CoA Ligase::Stilbene Synthase.
- Structure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from the Malaria Parasite Plasmodium falciparum: An Anti-Parasitic Drug Target.
- Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode haemonchus contortus.
- Transgenic soybean plants overexpressing O-acetylserine sulfhydrylase accumulate enhanced levels of cysteine and Bowman-Birk protease inhibitor in seeds.
- Structural and functional evolution of isopropylmalate dehydrogenases in leucine and glucosinolate pathways of Arabidopsis thaliana.
- Toward protein engineering for phytoremediation: possibilities and challenges.
- An elaborate heterotrimeric G-protein family from soybean expands the diversity of plant G-protein networks.
- Modulating plant hormones by enzyme action: The GH3 family of acyl acid amido synthetases.
- Kinetic basis for the conjugation of auxin by a GH3 family indole-acetic acid-amido synthetase.
- Threonine-insensitive homoserine dehydrogenase from soybean: genomic organization, kinetic mechanism, and in vivo activity.
- Structural basis for evolution of product diversity in soybean glutathione biosynthesis.
- A liquid chromatography-tandem mass spectrometry-based assay for indole-3-acetic acid-amido synthetase.
- The devil (and an active jasmonate hormone) is in the details.
- Assembly of the cysteine synthase complex and the regulatory role of protein-protein interactions.
- Contributions of conserved serine and tyrosine residues to catalysis, ligand binding, and cofactor processing in the active site of tyrosine ammonia lyase.
- A single amino acid change is responsible for evolution of acyltransferase specificity in bacterial methionine biosynthesis.
- An integrated protein chemistry laboratory: Chlorophyll and chlorophyllase.
- The role of 5'-adenylylsulfate reductase in the sulfur assimilation pathway of soybean: molecular cloning, kinetic characterization, and gene expression.
- Developing a new interdisciplinary lab course for undergraduate and graduate students: Plant cells and proteins.
- Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thaliana.
- Identification, characterization, epitope mapping, and three-dimensional modeling of the alpha-subunit of beta-conglycinin of soybean, a potential allergen for young p...
- Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase.
- Phosphoproteomic identification of targets of the Arabidopsis sucrose nonfermenting-like kinase SnRK2.8 reveals a connection to metabolic processes.
- Structural basis for interaction of O-acetylserine sulfhydrylase and serine acetyltransferase in the Arabidopsis cysteine synthase complex.
- Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and Mammalian cells.
- Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for ...
- Development of a high-throughput purification method and a continuous assay system for chlorophyllase.
- Soybean ATP sulfurylase, a homodimeric enzyme involved in sulfur assimilation, is abundantly expressed in roots and induced by cold treatment.
- Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis.
- Molecular basis of cysteine biosynthesis in plants: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana.
- Mechanistic analysis of wheat chlorophyllase.
- Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana.
- Arabidopsis thaliana glutamate-cysteine ligase: functional properties, kinetic mechanism, and regulation of activity.
- Role of hydrogen bonds in the reaction mechanism of chalcone isomerase.
- Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity.
- Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences.
- Effects of proteome rebalancing and sulfur nutrition on the accumulation of methionine rich δ-zein in transgenic soybeans.
- Impact of food processing on the safety assessment for proteins introduced into biotechnology-derived soybean and corn crops.
- Engineering steroid hormone specificity into aldo-keto reductases.
- The aldo-keto reductase (AKR) superfamily: an update.
- Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).
- Structural control of polyketide formation in plant-specific polyketide synthases.
- Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase.
- Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles ...
- Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase.
- A kaleidoscope of carotenoids.
- Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase.
- Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.
- Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase.
- Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases.
- Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD...
- A new nomenclature for the aldo-keto reductase superfamily.
- Comparative anatomy of the aldo-keto reductase superfamily.
- Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
- "Mammalian 3 alpha-hydroxysteroid dehydrogenases".
- A nomenclature system for the aldo-keto reductase superfamily.
- Structure and function of 3 alpha-hydroxysteroid dehydrogenase.
- Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein flu...
- Mammalian 3 alpha-hydroxysteroid dehydrogenases.
- Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
- Spectroscopic characterization of bendazac and benzydamine: possible photochemical modes of action.
- [Single cyst situated in the middle part of the kidney].
- [Developmental kidney anomaly under the form of a double calico-pyelic system (pelvis bifida)].
- Structure and mechanism of chalcone synthase-like polyketide synthases.
- Structure-guided programming of polyketide chain-length determination in chalcone synthase.
- Enzyme redesign.
- Proteins: the complete works.
- Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans.
- Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues.
- Nature''s assembly line: biosynthesis of simple phenylpropanoids and polyketides.
- Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.
- Comprehensive analysis of the Brassica juncea root proteome in response to cadmium exposure by complementary proteomic approaches.
- From sulfur to homoglutathione: thiol metabolism in soybean.
- Crystallization and preliminary X-ray diffraction analysis of salutaridine reductase from the opium poppy Papaver somniferum.
- Sensing sulfur conditions: simple to complex protein regulatory mechanisms in plant thiol metabolism.
- A redox-active isopropylmalate dehydrogenase functions in the biosynthesis of glucosinolates and leucine in Arabidopsis.
- 14-3-3 proteins fine-tune plant nutrient metabolism.
- Redox-regulatory mechanisms induced by oxidative stress in Brassica juncea roots monitored by 2-DE proteomics.
- Mutational analysis of YgfZ, a folate-dependent protein implicated in iron/sulphur cluster metabolism.
Schools
University of Texas Southwestern Medical Center At Dallas
University Tex Sw Med School Hospital
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
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University of Texas Southwestern Medical School
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