Professor, Medicine-Brigham and Women's Hospital, Harvard Medical School
Pediatric Pulmonology
Dr. Joshua A. Boyce, MD
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Joshua Boyce practices Pediatric Pulmonology. He researched medicine at University of Massachusetts Medical School. University of Massachusetts Medical School has a rank of 49 in research and a 12 in primary care He over the years received 1 awards: "Super Doctor". Joshua A. Boyce, MD is also published. He has 54 publications published. The lastest publication: "LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.'
Publications
- Cysteinyl leukotrienes and their receptors; emerging concepts.
- Cutting Edge: Leukotriene C4 Activates Mouse Platelets in Plasma Exclusively through the Type 2 Cysteinyl Leukotriene Receptor.
- Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes.
- Lipid mediators and Allergic diseases.
- Group V Secretory Phospholipase A2 Is Involved in Macrophage Activation and Is Sufficient for Macrophage Effector Functions in Allergic Pulmonary Inflammation.
- Pathogenesis of aspirin-exacerbated respiratory disease and reactions.
- Regulation of th9-type pulmonary immune responses.
- Advances in mechanisms of Allergy and clinical immunology in 2012.
- Cysteinyl leukotriene overproduction in aspirin exacerbated respiratory disease is driven by platelet-adherent leukocytes.
- NIAID-Sponsored 2010 Guidelines for Managing Food Allergy: Applications in the Pediatric Population.
- The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated.
- The Purinergic G Protein-Coupled Receptor 6 Inhibits Effector T Cell Activation in Allergic Pulmonary Inflammation.
- Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRI.
- LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release.
- Guidelines for the diagnosis and management of food Allergy in the United States: summary of the NIAID-Sponsored Expert Panel report.
- Group V secretory phospholipase A2 reveals its role in house dust mite-induced Allergic pulmonary inflammation by regulation of dendritic cell function.
- Key advances in mechanisms of Asthma, allergy, and immunology in 2009.
- Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in Allergic airway inflammation.
- Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor.
- The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications.
- STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection.
- Advances in mechanisms of Asthma, allergy, and immunology in 2008.
- P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells.
- Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells.
- CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.
- Coordinated involvement of mast cells and T cells in Allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis.
- Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung.
- Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling.
- Asthma 2005-2006: bench to bedside.
- Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell.
- Mast cell biology in evolution.
- Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE.
- Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses.
- Lysophospholipids as mediators of immunity.
- IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells.
- No audible wheezing: nuggets and conundrums from mouse Asthma models.
- Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptor.
- Lysophosphatidic acid accelerates the development of human mast cells.
- Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses.
- The biology of the mast cell.
- Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.
- FcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines.
- The idiopathic hypereosinophilic syndrome.
- Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R.
- CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13.
- Mast cells: beyond IgE.
- Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresp...
- Prolonged anticonvulsant hypersensitivity syndrome related to lamotrigine in a patient with human immunodeficiency virus.
- CCR3 is required for tissue Eosinophilia and larval cytotoxicity after infection with Trichinella spiralis.
- Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.
- Mast cell growth, differentiation, and death.
- Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotrie...
- LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in Asthma.
Schools
University Of Massachusetts Medical School
Umass Memorial Med Center
Brigham and Women39s Hospital
Massachusetts General Hospital
Procedures Preformed
- Allergy Skin Testing
- Drug or Food Challenge
Conditions Treated
- Allergic Rhinitis
- Animal Allergies
- Asthma
- Bronchiectasis
- View All
Doctors Specialties
- Pediatric Pulmonology
Accepted Insurances
Awards
- Super Doctor
Education
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Brigham and Women's Hospital -
Massachusetts General Hospital -
University of Massachusetts -
University of Massachusetts Medical School
Hospital
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Newton-Wellesley Hospital -
Massachusetts General Hospital -
Brigham and Women's Hospital
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