Professor, Medicine, University of California San Diego School of Medicine
Endocrinology
Dr. Karl Y. Hostetler, MD
Doctor Karl Y. Hostetler, MD works in the field of Endocrinology. He graduated from Case Western Reserve University School of Medicine. He over the years received 3 awards: "Gertrude Elion Memorial Award", "CMS Meaningful Use Stage 1 Certification" and "Elected Member". Karl Hostetler is a published physician as well. He has 101 publications published. The latest was: Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and hum... Doctor Karl Y. Hostetler, MD accepts Medicare.
Publications
- Micelle formulation of hexadecyloxypropyl-cidofovir (HDP-CDV) as an intravitreal long-lasting delivery system.
- Intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV) as a long-lasting intravitreal antiviral drug.
- Inhibition of HIV-1 by Octadecyloxyethyl Esters of (S)-[3- Hydroxy-2-(phosphonomethoxy)propyl] Nucleosides and Evaluation of Their Mechanism of Action.
- Application of kinase bypass strategies to nucleoside antivirals.
- Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: Inhibitors of hepatitis C virus and HIV-1 replication.
- Intraocular pharmacokinetics of a crystalline Lipid prodrug, octadecyloxyethyl-cyclic-cidofovir, for cytomegalovirus retinitis.
- Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir.
- Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection.
- Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphona...
- Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV...
- The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genoType 1A...
- Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
- Anti-BK virus activity of nucleoside analogs.
- Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template ...
- Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia...
- Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus Type 1 and hepatitis B vi...
- Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit...
- Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.
- Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenoType.
- Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-Type and drug-resistant human immunodeficien...
- Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and ...
- Ether Lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.
- Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
- Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical Cancer cells in vitro.
- Comparative activities of Lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.
- Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate.
- Intraocular properties of hexadecyloxypropyl-cyclic-cidofovir in Guinea pigs.
- Ether Lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.
- Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.
- Characterization of a novel intraocular drug-delivery system using crystalline Lipid antiviral prodrugs of ganciclovir and cyclic cidofovir.
- Oral treatment of murine cytomegalovirus infections with ether Lipid esters of cidofovir.
- Oral activity of ether Lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.
- Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.
- Oral treatment of cowpox and vaccinia virus infections in mice with ether Lipid esters of cidofovir.
- Efficacy of oral active ether Lipid analogs of cidofovir in a lethal mousepox model.
- Ganciclovir release rates in vitreous from different formulations of 1-O-hexadecylpropanediol-3-phospho-ganciclovir.
- Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.
- Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.
- Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.
- Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir.
- Pathways of glucose metabolism in the isolated islet of the goosefish in vitro.
- Nursing station order entry for hospital computers.
- Antiproliferative property of hexadecyloxypropyl 9-[2-(phosphonomethoxy) ethyl] guanine (HDP-PMEG) for unwanted ocular proliferation.
- Intravitreal crystalline drug delivery for intraocular proliferation Diseases.
- Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
- Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art.
- Design and development of oral drugs for the prophylaxis and treatment of smallpox infection.
- Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical Cancer cells in vitro and in vivo.
- Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.
- Synthesis and early development of hexadecyloxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate.
- Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.
- Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice.
- Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro.
- Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice.
- Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine.
- Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
- In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.
- Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates.
- Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.
- Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice.
- Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus Type 1- and hum...
- Cardiolipin synthase from mammalian mitochondria.
- Alkoxy propane prodrugs of foscarnet: effect of alkyl chain length on in vitro antiviral activity in cells infected with HIV-1, HSV-1 and HCMV.
- Synthesis and in vitro activity of long-chain 5'-O-[(alkoxycarbonyl)phosphinyl]-3'-azido-3'-deoxythymidines against wild-Type and AZT- and foscarnet-resistant strains ...
- Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro.
- Evaluation of a novel Lipid prodrug for intraocular drug delivery: effect of acyclovir diphosphate dimyristoylglycerol in a rabbit model with herpes simplex virus-1 re...
- Lipid prodrugs of phosphonoacids: greatly enhanced antiviral activity of 1-O-octadecyl-sn-glycero-3-phosphonoformate in HIV-1, HSV-1 and HCMV-infected cells, in vitro.
- Liver-targeted antiviral nucleosides: enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo.
- Phosphatidyl-2'',3''-dideoxy-3''-thiacytidine: synthesis and antiviral activity in hepatitis B-and HIV-1-infected cells.
- Comparative evaluation of amiodarone-induced phosphoLipidosis and drug accumulation in Fischer-344 and Sprague-Dawley rats.
- Lysosomal phosphatidylcholine: bis(monoacylglycero)phosphate acyltransferase: specificity for the sn-1 fatty acid of the donor and co-purification with phospholipase A1.
- Mitochondrial cardiolipin in diverse eukaryotes. Comparison of biosynthetic reactions and molecular acyl species.
- Acyclovir diphosphate dimyristoylglycerol: a phosphoLipid prodrug with activity against acyclovir-resistant herpes simplex virus.
- Synthesis and antiviral activity of 3''-azido-3''-deoxythymidine triphosphate distearoylglycerol: a novel phosphoLipid conjugate of the anti-HIV agent AZT.
- PhosphoLipid prodrug inhibitors of the HIV protease. Antiviral activity and pharmacokinetics in rats.
- Antiviral activity of phosphatidyl-dideoxycytidine in hepatitis B-infected cells and enhanced hepatic uptake in mice.
- Phosphatidylazidothymidine and phosphatidyl-ddC: assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunoDeficiency virus-infected cells...
- Phospholipase C activity of rat tissues.
- Properties of phospholipase C isolated from rat liver lysosomes.
- Studies on the mechanism of drug-induced Lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C.
- The intracellular distribution and antiviral activity of amantadine.
- Studies on the mechanism of phosphoLipid storage induced by amantadine and chloroquine in Madin Darby canine kidney cells.
- Purification of lysosomal phospholipase A. Evidence for multiple isoenzymes in rat liver.
- Aminoglycoside antibiotics inhibit lysosomal phospholipase A and C from rat liver in vitro.
- Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity.
- Effect of nonspecific phosphoLipid transfer protein on cholesterol esterification in microsomes from Morris hepatomas.
- PhosphoLipid transfer activities in Morris hepatomas and the specific contribution of the phosphatidylcholine exchange protein.
- Liposome entrapment enhances the hypocalcemic action of parenterally administered calcitonin.
- Effect of cationic amphiphilic drugs on the hydrolysis of acidic and neutral phosphoLipids by liver lysosomal phospholipase A.
- Chloroquine treatment does not cause phosphoLipid storage by depleting rat liver lysosomes of acid phospholipase A.
- Effects of chloroquine and 4,4''-bis(diethylaminoethoxy)alpha, beta-diethyldiphenylethane on the incorporation of [3H]glycerol into the phosphoLipids of rat liver lyso...
- Deficiency of carnitine palmitoyltransferase in transformed lymphoblasts from a patient having a Deficiency of carnitine palmitoyltransferase in skeletal muscle.
- Studies on drug-induced Lipidosis: subcellular localization of phosphoLipid and cholesterol in the liver of rats treated with chloroquine or 4,4'-bis (diethylaminoetho...
- Inhibition of lysosomal phospholipase A and phospholipase C by chloroquine and 4,4'-bis(diethylaminoethoxy) alpha, beta-diethyldiphenylethane.
- Molecular studies of the induction of cellular phosphoLipidosis by cationic amphiphilic drugs.
- Estimation of the pentose cycle contribution to glucose metabolism in tissue in vivo.
- Conversion of specifically 14 C-labeled lactate and pyruvate to glucose in man.
- The effect of L-epinephrine and triamcinolone on the incorporation of acetate-2-14C and 32Pi into phospholipids and neutral lipids in liver slices from Adrenalectomize...
- The synthesis and utilization of dCDP-diglyceride by a mitochondrial fraction from rat liver.
- Quantitation of the pathways of fructose metabolism in normal and fructose-intolerant subjects.
Schools
Case Western Reserve University School of Medicine
University Hospitals Case Medical Center
Cleveland Clinic
Conditions Treated
- Abnormal Thyroid
- Acromegaly and Gigantism
- Adrenal Insufficiency
- Diabetes Type 2
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Doctors Specialties
- Endocrinology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Power Select HMO
- Blue Card PPO
- CaliforniaCare HMO
- Advantage Preferred DirectAccess Plus PPO
- Blue Cross Blue Shield of California PPO
- Pathway X Direct Access PPO
- Pathway X Tiered Direct Access
- Select Plus HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- First Health (Coventry Health Care) PPO
- GEHA
- Medicare Advantage PFFS
- Medicare MCR
- Kaiser PHCS Network PPO
- MultiPlan PPO
- PHCS Network PPO
- Heritage Signature
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- PacifiCare HMO
- United Healthcare
Awards
- Gertrude Elion Memorial Award
- CMS Meaningful Use Stage 1 Certification
- Elected Member
Education
-
Cleveland Clinic Foundation -
Case Western Reserve University - University Hospitals -
Case Western Reserve University School of Medicine
Hospital
-
UC San Diego Health
Drug Facts
| NPI NUMBER | 1477501450 | |
| NPPES Provider LastName | HOSTETLER | |
| NPPES Provider FirstName | KARL | |
| NPPES Provider ZIPCode | 921038201 | |
| NPPES Provider State | CA | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 73.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1477501450 |
| Last Name Of The Provider | HOSTETLER |
| First Name Of The Provider | KARL |
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