Professor, Medicine, University of Chicago Div of the Bio Sci The Pritzker SOM
Endocrinology
Dr. Kenneth S. Polonsky, MD
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Doctor Kenneth S. Polonsky, MD practices Endocrinology. He received awards:"Elected Member" and "Fellow (FACP)". Kenneth Polonsky is a published doctor. He has 56 publications published. The most current publication "Donald F. Steiner, MD, 1930-2014: pioneering diabetes researcher."
Publications
- Donald F. Steiner, MD, 1930-2014: pioneering diabetes researcher.
- Donald F. Steiner MD, 1930-2014: discoverer of proinsulin.
- BH3-only molecule Bim mediates β-cell death in IRS2 deficiency.
- β-cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment.
- The role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency.
- Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes.
- Moderate Effect of Duodenal-Jejunal Bypass Surgery on Glucose Homeostasis in Patients With Type 2 Diabetes.
- Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes.
- Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes.
- Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism.
- Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.
- Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.
- TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
- Serum leptin levels in obese males during over- and underfeeding.
- Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cells.
- Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
- Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal ...
- To nap or not to nap? Residents' work hours revisited.
- Calpain-10 is a component of the obesity-related quantitative trait locus, Adip1.
- The physician scientist training program in internal medicine at Washington University School of Medicine.
- Insulin signaling in alpha cells modulates glucagon secretion in vivo.
- Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.
- Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.
- Standardization of C-peptide measurements.
- Weight loss therapy improves pancreatic endocrine function in obese older adults.
- International comparison of C-peptide measurements.
- Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
- Suppressed insulin signaling and increased apoptosis in CD38-null islets.
- International trial of the Edmonton protocol for islet transplantation.
- Inhibition of calpain results in impaired contraction-stimulated GLUT4 translocation in skeletal muscle.
- A significant role for histocompatibility in human islet transplantation.
- Retinol-binding protein 4, insulin resistance, and type 2 diabetes.
- Insulin sensitivity by oral glucose minimal models: validation against clamp.
- Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individu...
- Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic, insulin-resistant individuals.
- Diabetic pancreatic beta cells ARNT all they should be.
- Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin cont...
- Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
- Impaired beta-cell compensation to dexamethasone-induced hyperglycemia in women with polycystic ovary syndrome.
- Portal vein thrombosis complicating islet transplantation in a recipient with the Factor V Leiden mutation.
- RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
- Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.
- Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.
- C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.
- Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury.
- Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.
- Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
- A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
- Organ alchemy: producing insulin in the liver.
- Increased islet apoptosis in Pdx1+/- mice.
- Visualizing superoxide production in normal and diabetic rat islets of Langerhans.
- Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.
- Diagnosis of acromegaly in a patient with type 1 diabetes mellitus.
- Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times.
- Phase-locking regions in a forced model of slow insulin and glucose oscillations.
Schools
University of The WitwatersrandFaculty of Health Sciences
Johannesburg Genl Hospital
Edward Hines Jr Va Hospital
Michael Reese Hospital and Med Center
University of Chicago
Doctors Specialties
- Internal Medicine
- Endocrinology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACP)
Education
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University of Chicago -
University of the Witwatersrand
Hospital
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University of Chicago Medical Center
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