Physician

Radiology

Dr. Kevin O. Hicks, MD

Kevin Hicks is an expert in the field of Radiology. He researched medicine at Virginia Commonwealth University School of Medicine. Doctor Kevin O. Hicks, MD is also published. He has 22 publications published. The lastest publication: "Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model.' Kevin Hicks accepts Medicare payments and is registered with Medicare.gov.

Publications

Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors.
Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.
Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.
Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular tr...
Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine.
Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.
Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.
Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures.
Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: implications for extravascular transport and activity in tumors.
In vitro and in vivo models for evaluation of GDEPT: quantifying bystander killing in cell cultures and tumors.
Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures.
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.
Measurement of extravascular drug diffusion in multicellular layers.
Multicellular membranes as an in vitro model for extravascular diffusion in tumours.
Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Cytotoxicity, DNA binding, cellular uptake, and metabolism.
An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours.
Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicell...
Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model.
Analysis of the hypoxia-activated dinitrobenzamide mustard phosphate pre-prodrug PR-104 and its alcohol metabolite PR-104A in plasma and tissues by liquid chromatograp...
A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

Schools

Virginia Commonwealth University Medical College Of Virginia School Of Medicine

Doctors Specialties

Diagnostic Radiology
Radiology

Accepted Insurances

Education

University of Mississippi Medical Center
Virginia Commonwealth University School of Medicine

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Medicare Facts

National Provider Identifier [NPI]	1669490413
Last Name Of The Provider	HICKS
First Name Of The Provider	KEVIN
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