Division Head Pediatric Critical Care Head Cardiovascular Pulmonary Research University Colorado
Pediatric Pulmonology
Dr. Kurt R. Stenmark, MD
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Kurt Stenmark practices Pediatric Pulmonology. He attended University of Colorado Denver School of Medicine. University of Colorado Denver School of Medicine is a one of the best medicals schools. University of Colorado Denver School of Medicine is ranked 35/8 in Research/PrimaryCare. Kurt R. Stenmark, MD is a published doctor as well. He has 102 publications published. The latest was: Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension.
Publications
- Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension.
- Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension.
- Differential regulation of matrix metalloproteinases in varicella zoster virus-infected human brain vascular adventitial fibroblasts.
- Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with...
- Vascular stiffening in pulmonary hypertension: cause or consequence? (2013 Grover Conference series).
- Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.
- Chemotherapy-Induced Pulmonary Hypertension: Role of Alkylating Agents.
- The Role of Inflammation in Hypoxic Pulmonary Hypertension: from cellular mechanisms to clinical phenotypes.
- Mitochondrial Integrity in a Neonatal Bovine Model of Right Ventricular Dysfunction.
- Is uric Acid an underdiagnosed mediator of adverse outcome in metabolically healthy overweight/obese individuals?
- Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension.
- Gene expression and β-adrenergic signaling are altered in hypoplastic left heart syndrome.
- High proliferative potential endothelial colony forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization.
- Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension.
- Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes.
- MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts.
- Bronchus-Associated Lymphoid Tissue in Pulmonary Hypertension Produces Pathologic Autoantibodies.
- High Pulsatility Flow Induces Acute Endothelial Inflammation through Overpolarizing Cells to Activate NF-κB.
- The adventitia: essential regulator of vascular wall structure and function.
- Mechanics and mechanisms of pulmonary hypertension: An introduction to the 55(th) annual Thomas L. Petty Aspen Lung Conference.
- Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries.
- MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension.
- High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile protein expression.
- Stiffening-Induced High Pulsatility Flow Activates Endothelial Inflammation via a TLR2/NF-κB Pathway.
- Biomarkers for Pediatric Pulmonary Arterial Hypertension - A Call to Collaborate.
- Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via Gi and Akt-Dependent Actin Cytoskeleton Remodeling.
- "Bioengineering the lung: molecules, materials, matrix, morphology, and mechanics".
- Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
- Progenitor cells in pulmonary vascular remodeling.
- Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells.
- Linked opening angle and histological and mechanical aspects of the proximal pulmonary arteries of healthy and pulmonary hypertensive rats and calves.
- Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension.
- Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury.
- Endothelin-1, the unfolded protein response, and persistent inflammation: role of pulmonary artery smooth muscle cells.
- Varicella zoster virus vasculopathy: analysis of virus-infected arteries.
- Circulating fibrocytes are increased in children and young adults with pulmonary hypertension.
- Physiologic and molecular consequences of endothelial Bmpr2 mutation.
- Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension.
- A microstructurally driven model for pulmonary artery tissue.
- Cell-based therapies in pulmonary hypertension: who, what, and when?
- Complementary effects of extracellular nucleotides and platelet-derived extracts on angiogenesis of vasa vasorum endothelial cells in vitro and subcutaneous Matrigel p...
- Fibrocytes: potential new therapeutic targets for pulmonary hypertension?
- P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.
- Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration.
- Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
- Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling.
- Emerging therapies for the treatment of pulmonary hypertension.
- In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation.
- Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner.
- Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall.
- Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.
- PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells.
- Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors.
- Cellular and molecular basis of pulmonary arterial hypertension.
- Inflammation, growth factors, and pulmonary vascular remodeling.
- Peroxisome proliferator-activated receptor-g agonist treatment increases septation and angiogenesis and decreases airway hyperresponsiveness in a model of experimental...
- Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment.
- High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells.
- Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension.
- Lung vascular cell heterogeneity: endothelium, smooth muscle, and fibroblasts.
- Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves.
- Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling.
- Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling.
- Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia.
- Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells.
- Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension.
- Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.
- Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.
- Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and e...
- Role of the adventitia in pulmonary vascular remodeling.
- Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development.
- Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression.
- Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage.
- Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling.
- Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling.
- Hypoxia-induced alterations in protein kinase C zeta signaling result in augmented fibroblast proliferation.
- Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia.
- Angiogenic therapy for bronchopulmonary dysplasia: rationale and promise.
- Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia.
- Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal?
- Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia.
- Distensibility of the normal human lung circulation during exercise.
- Hypoxia, leukocytes, and the pulmonary circulation.
- Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling ...
- Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferat...
- Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts.
- Cellular and molecular pathobiology of pulmonary arterial hypertension.
- Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.
- Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and i...
- Yin and Yang of an endothelial cell: from normal to the extreme in growth, secretion, and transdifferentiation capabilities.
- Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis.
- Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts.
- Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression.
- Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities.
- Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling.
- Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells.
- Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase.
- Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase.
- Lung vascular development: breathing new life into an old problem.
- Hypoxic activation of adventitial fibroblasts: role in vascular remodeling.
- Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension.
Schools
University Of Colorado Denver School Of Medicine
University Of Colorado
Conditions Treated
- Sleep Apnea
Doctors Specialties
- Pediatric Pulmonology
Accepted Insurances
Education
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University of Colorado -
University of Colorado Denver School of Medicine
Hospital
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Children's Hospital Colorado
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