Fellow, Cardiology, University of Pennsylvania

Cardiology

Dr. Lawrence T. Bish, MD

Lawrence Bish practices Cardiology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. Lawrence T. Bish is also a published MD. He has 34 publication published. The most recent publication is: Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus.

Publications

Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus.
Enhancing the Utility of Adeno-Associated Virus Gene Transfer through Inducible Tissue-Specific Expression.
Long-term Restoration of Cardiac Dystrophin Expression in Golden Retriever Muscular Dystrophy Following rAAV6-mediated Exon Skipping.
Long-Term Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Golden Retriever Muscular Dystrophy.
Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.
Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques.
Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine.
Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice.
Myostatin is elevated in congenital Heart disease and after mechanical unloading.
Adeno-associated virus vector delivery to the Heart.
Thyroid storm after coronary artery bypass grafting.
Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy.
Status of therapeutic gene transfer to treat canine dilated cardiomyopathy in dogs.
Molecular analysis of vector genome structures after liver transduction by conventional and self-complementary adeno-associated viral serotype vectors in murine and no...
Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice.
Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model.
Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes.
Gene therapy in large animal models of human cardiovascular genetic disease.
Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.
Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines.
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance.
Systemic administration of L-arginine benefits mdx skeletal muscle function.
Inhibition of matrix metalloproteinase activity by TIMP-1 gene transfer effectively treats ischemic cardiomyopathy.
Administration of a tumor necrosis factor inhibitor at the time of myocardial infarction attenuates subsequent ventricular remodeling.
Local myocardial overexpression of growth hormone attenuates postinfarction remodeling and preserves cardiac function.
Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia.
Gene transfer of hepatocyte growth factor attenuates postinfarction Heart failure.
Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain.
Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic Heart failure.
Targeted overexpression of growth hormone by adenoviral gene transfer preserves myocardial function and ventricular geometry in ischemic cardiomyopathy.
Induction of angiogenesis and inhibition of apoptosis by hepatocyte growth factor effectively treats postischemic Heart failure.
Myostatin activation in patients with advanced Heart failure and after mechanical unloading.
Status of therapeutic gene transfer to treat cardiovascular disease in dogs and cats.

Schools

Perelman School of Medicine University of Pennsylvania

Conditions Treated

Congestive Heart Failure

Doctors Specialties

Cardiology

Accepted Insurances

Education

University of Pennsylvania Health System
Perelman School of Medicine at the University of Pennsylvania

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