Professor, Pediatrics, Ohio State University College of Medicine
Neonat/Perinatology
Dr. Leif D. Nelin, MD
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Leif Nelin practices Neonat/Perinatology. He went to medical school at University of South Florida College of Medicine. University of South Florida College of Medicine is ranked 79 in research and 85 in primary care medicine He received 1 awards: "Fellow (FAAP)". Leif Nelin is a published physician as well. He has 95 publications published. The latest was: L-arginine uptake and metabolism by lung macrophages and neutrophils following intratracheal instillation of silica in vivo.
Publications
- Pulmonary Vein Stenosis in Neonates with Severe Bronchopulmonary Dysplasia.
- Impact of Process Optimization and Quality Improvement Measures on Neonatal Feeding Outcomes at an All-Referral Neonatal Intensive Care Unit.
- Extracellular signal-regulated kinase mediates expression of arginase II but not inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages.
- Plasma Asymmetric Dimethylarginine Levels Are Increased in Neonates with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension.
- Post-translational Regulation of Mitogen-activated Protein Kinase Phosphatase (MKP)-1 and MKP-2 in Macrophages Following Lipopolysaccharide Stimulation: THE ROLE OF TH...
- Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells.
- Inhaled nitric oxide usage in preterm infants in the NICHD neonatal research network: inter-site variation and propensity evaluation.
- Asymmetric dimethyl arginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells.
- Empowerment programme for parents of extremely premature infants significantly reduced length of stay and readmission rates.
- Respiratory severity score on day of life 30 is predictive of mortality and the length of mechanical ventilation in premature infants with protracted ventilation.
- Lung Development Alterations in Newborn Mice after Recovery from Exposure to Sublethal Hyperoxia.
- In Vitro Evaluation of Radiolabeled Aerosol Delivery via a Variable Flow Infant CPAP System.
- Therapeutic interventions and short-term outcomes for infants with severe bronchopulmonary dysplasia born at <32 weeks' gestation.
- Bronchopulmonary dysplasia and neurodevelopmental outcome in extremely preterm neonates.
- Glutathione Reductase Is Essential for Host Defense against Bacterial Infection.
- Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine.
- Factors Associated with Maternal Visitation and Participation in Skin-to-Skin Care in an All Referral Level IIIc NICU.
- Pharmacologic Agents Elevating cAMP Prevent Arginase II Expression and Proliferation of Pulmonary Artery Smooth Muscle Cells.
- Lipopolysaccharide-induced Cyclooxygenase-2 Expression in Mouse Transformed Clara Cells.
- Cancer in pregnancy: fetal and neonatal outcomes.
- Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells.
- Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.
- Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.
- Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen.
- Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.
- Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.
- Inhaled nitric oxide decreases leukocyte trafficking in the neonatal mouse lung during exposure to >95% oxygen.
- Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase.
- Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.
- Alterations of the thioredoxin system by hyperoxia: implications for alveolar development.
- Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1.
- Tissue Doppler changes in three neonates with congenital diaphragmatic hernia.
- Triptolide induces anti-inflammatory cellular responses.
- Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen.
- Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.
- Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia.
- Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.
- Spatiotemporal characteristics of acid refluxate and relationship to symptoms in premature and term infants with chronic lung disease.
- Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats.
- MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.
- Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria.
- Assessing heparin dosing in neonates on venoarterial extracorporeal membrane oxygenation.
- Hyperoxia increases hepatic arginase expression and ornithine production in mice.
- Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.
- MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock.
- Mean airway pressure and response to inhaled nitric oxide in neonatal and pediatric patients.
- Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.
- The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosy...
- Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats.
- Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells.
- L-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs.
- The effect of inhaled nitric oxide and oxygen on the hydroxylation of salicylate in rat lungs.
- Exhaled NO is reduced at an early stage of hypoxia-induced pulmonary hypertension in newborn piglets.
- Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat.
- Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric oxide.
- L-Arginine uptake and metabolism following in vivo silica exposure in rat lungs.
- Increased incidence of idiopathic persistent pulmonary hypertension in Down syndrome neonates.
- Implementation of a multidisciplinary guideline-driven approach to the care of the extremely premature infant improved hospital outcomes.
- Multicenter crossover study of automated control of inspired oxygen in ventilated preterm infants.
- The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia.
- MAPK phosphatases--regulating the immune response.
- Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.
- Influence of flow on pulmonary vascular surface area inferred from blue dextran efflux data.
- A simple distensible vessel model for interpreting pulmonary vascular pressure-flow curves.
- Use of diazepam for interpreting changes in extravascular lung water.
- Effect of positioning on the breathing pattern of preterm infants.
- The effect of blood flow and left atrial pressure on the DLCO in lambs and sheep.
- Effect of atelectasis and surface tension on pulmonary vascular compliance.
- The effect of N omega-nitro-L-arginine methylester on hypoxic vasoconstriction in the neonatal pig lung.
- Identification of sepsis in neonates following maternal antibiotic therapy.
- Two cases suggesting a role for the L-arginine nitric oxide pathway in neonatal blood pressure regulation.
- The effect of inhaled nitric oxide on the pulmonary circulation of the neonatal pig.
- The vascular site of action of hypoxia in the neonatal pig lung.
- Traumatic pseudodiverticulum of the pharynx.
- A distensible vessel model applied to hypoxic pulmonary vasoconstriction in the neonatal pig.
- Relationship between nutrition, weight change, and fluid compartments in preterm infants during the first week of life.
- Cardiac arrest in an extremely low birth weight infant: complication of percutaneous central venous catheter hyperalimentation.
- Effect of hypoxia on nitric oxide production in neonatal pig lung.
- Electrochemical nitric oxide and nitrogen dioxide analyzer for use with inhaled nitric oxide.
- Inhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn.
- Biotinylation of membrane proteins accessible via the pulmonary circulation in normal and hyperoxic rats.
- Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs.
- Nitric oxide increases the survival of rats with a high oxygen exposure.
- The use of inhaled nitric oxide in a wide variety of clinical problems.
- L-arginine uptake and metabolism by lung macrophages and neutrophils following intratracheal instillation of silica in vivo.
- Effects of chronic pulmonary overcirculation on pulmonary vasomotor tone.
- Pulmonary vascular responses during acute and sustained respiratory alkalosis or acidosis in intact newborn piglets.
- L-Arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs.
- Systemic lobar shunting induces advanced pulmonary vasculopathy.
- Nitric oxide-dependent pulmonary vasodilation in polycythemic rats.
- Role of endothelin in intermittent hypoxia-induced hypertension.
- The arterial site of action of nitric oxide in the neonatal pig lung determined by microfocal angiography.
- Cytokine treatment increases arginine metabolism and uptake in bovine pulmonary arterial endothelial cells.
- L-arginine infusion lowers blood pressure in children.
Schools
University Of South Florida College Of Medicine
Baylor
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
Awards
- Fellow (FAAP)
Education
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Baylor College of Medicine -
University of South Florida College of Medicine
Hospital
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Nationwide Children's Hospital -
Ohio State University Wexner Medical Center
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