Associate Professor, Pediatrics, University of Cincinnati College of Medicine
Pediatrics
Dr. Lesley A. Doughty, MD
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Doctor Lesley A. Doughty, MD is an expert in the field of Pediatrics. She graduated from Geisel School of Medicine at Dartmouth. Geisel School of Medicine at Dartmouth has a rank of 37 in research and a 29 in primary care Lesley A. Doughty, MD is a published doctor. She published 28 publications, including: 'The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure.'
Publications
- Validation of a gene expression-based subclassification strategy for pediatric septic shock.
- Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept.
- Admission angiopoietin levels in children with septic shock.
- Activation of common antiviral pathways can potentiate inflammatory responses to septic shock.
- In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice.
- Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessme...
- Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis.
- Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.
- Plasma concentrations of defensins and lactoferrin in children with severe sepsis.
- Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox.
- Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-...
- Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10.
- A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin.
- Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.
- The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure.
- Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock.
- Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock.
- Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are increased in the plasma of children with sepsis-induced multiple organ failure.
- Plasma nitrite and nitrate concentrations and multiple organ failure in pediatric sepsis.
- Plasma bactericidal/permeability-increasing protein concentrations in critically ill children with the sepsis syndrome.
- Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure.
- Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.
- SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis.
- sFas and sFas ligand and pediatric sepsis-induced multiple organ failure syndrome.
- The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure.
- The Accreditation Council for Graduate Medical Education proposed work hour regulations.
- Acute renal replacement therapy in pediatrics.
Schools
Dartmouth Medical School
Doctors Specialties
- Pediatric Critical Care Medicine
- Pediatrics
Accepted Insurances
Education
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Tripler Army Medical Center -
Geisel School of Medicine at Dartmouth
Hospital
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Cincinnati Children's Hospital Medical Center
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