Associate Professor, Pediatrics-Children's Hospital, Harvard Medical School
Pediatric Hematology & Oncology
Dr. Loren D. Walensky, MD
|
|
Give Review
Loren D. Walensky, MD works in the field of Pediatric Hematology & Oncology. He attended Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical university. Johns Hopkins University School of Medicine is ranked 3/29 in Research/PrimaryCare. He over the years received 1 awards: "Elected Member". Dr. Loren D. Walensky is a published physician as well. He has 60 publications published. The latest was: Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities.
Publications
- SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
- Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism.
- Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.
- Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes.
- Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.
- Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.
- Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress.
- Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
- A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators.
- Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies.
- Mantle Cell Lymphoma in Cyclin D1 Transgenic Mice with Bim-deficient B-cells.
- Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.
- Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK.
- Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3.
- Direct BAKtivation.
- The retinoblastoma protein induces apoptosis directly at the mitochondria.
- Playing FullBAK.
- Protein-protein interactions: A PUMA mechanism unfolds.
- Direct activation of full-length proapoptotic BAK.
- Interview: interview with loren d walensky.
- From Mitochondrial Biology to Magic Bullet: Navitoclax Disarms BCL-2 in Chronic Lymphocytic Leukemia.
- BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.
- Tracking BAX once its trigger is pulled.
- Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.
- A stapled p53 helix overcomes HDMX-mediated suppression of p53.
- BH3-triggered structural reorganization drives the activation of proapoptotic BAX.
- Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.
- The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.
- Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
- Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains.
- Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains.
- The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members.
- Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.
- A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro.
- A stapled BID BH3 helix directly binds and activates BAX.
- Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
- Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron.
- Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
- Photoreactive Stapled Peptides to Identify and Characterize BCL-2 Family Interaction Sites by Mass Spectrometry.
- Characterization of a core fragment of the rhesus monkey TRIM5α protein.
- BAX activation is initiated at a novel interaction site.
- Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.
- Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities.
- Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.
- A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1.
- Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor.
- Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain.
- Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association.
- BCL-2 in the crosshairs: tipping the balance of life and death.
- Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.
- Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.
- A novel M(r) 32,000 nuclear phosphoprotein is selectively expressed in cells competent for self-renewal.
- Odorant receptors and desensitization proteins colocalize in mammalian sperm.
- The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1.
- Two novel odorant receptor families expressed in spermatids undergo 5'-splicing.
- Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family.
- The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility.
- Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1.
- Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.
Schools
Johns Hopkins University School Of Medicine
Children39s Hospital
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
- Blue Card PPO
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- Great West Healthcare-Cigna PPO
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Tufts Health Plans
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Elected Member
Education
-
Boston Children's Hospital -
Johns Hopkins University School of Medicine
Hospital
-
Boston Children's Hospital -
Brigham and Women's Hospital -
Massachusetts General Hospital -
Dana-Farber Cancer Institute
Helpful Reviews
Similar Doctors
|
|
Dr. Holcombe E. Grier, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Kimberly Stegmaier, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Amy L. Billett, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Virginia M. Hamilton, MD |
|
|
Dr. Alan D. Dandrea, MD
This Doctor is OpenDoctor Recommended.
|