Physician

Internal Medicine

Doctor Malcolm M. Martin, MD is an expert in the field of Internal Medicine. Malcolm Martin is a published MD. He published 38 publications, including: 'Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.'

Publications

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• Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.
• Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
• Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.
• Emergence of gp120 V3 Variants Confers Neutralization Resistance in an R5 Simian-Human Immunodeficiency Virus-Infected Macaque Elite Neutralizer That Targets the N332 ...
• Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
• Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque.
• The Acute HIV Infection: Implications For Intervention, Prevention and Development of an Effective AIDS Vaccine.
• Recombination Mediated Changes in Coreceptor Usage Confers an Augmented Pathogenic Phenotype in a Non-human Primate Model of HIV-1 Induced AIDS.
• SOME HIV-1 VPU PROTEINS ARE ABLE TO ANTAGONIZE MACAQUE BST-2 IN VITRO AND IN VIVO: VPU NEGATIVE SHIVS ARE ATTENUATED IN VIVO.
• The Simian Immunodeficiency Virus Targets Central Cell Cycle Functions through Transcriptional Repression In vivo.
• Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques.
• Neutralizing antibody titers conferring protection to macaques from a simian/human immunodeficiency virus challenge using the TZM-bl assay.
• Initiation of antiretroviral therapy 48 hours after infection with simian immunodeficiency virus potently suppresses acute-phase viremia and blocks the massive loss of...
• High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections.
• Importance of the V1/V2 loop region of simian-human immunodeficiency virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibo...
• Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in imm...
• Human immunodeficiency virus type 1 derivative with 7% simian immunodeficiency virus genetic content is able to establish infections in pig-tailed macaques.
• Unique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS.
• The locus encoding an oligomorphic family of MHC-A alleles (Mane-A*06/Mamu-A*05) is present at high frequency in several macaque species.
• Loss of naïve cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques.
• Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells.
• CD8+ and CD20+ lymphocytes cooperate to control acute simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys: modulatio...
• Resting naive CD4+ T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques.
• Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses.
• Pig-tailed macaques (Macaca nemestrina) possess six MHC-E families that are conserved among macaque species: implication for their binding to natural killer receptor v...
• Induction of disease by a molecularly cloned highly pathogenic simian immunodeficiency virus/human immunodeficiency virus chimera is multigenic.
• Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development.
• Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar ma...
• The emergence and characterization of macrophage-tropic SIV/HIV chimeric viruses (SHIVs) present in CD4+ T cell-depleted rhesus monkeys.
• Early control of highly pathogenic simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys usually results in long-lasti...
• Characterization of pig-tailed macaque classical MHC class I genes: implications for MHC evolution and antigen presentation in macaques.
• Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivate...
• Amino acid deletions are introduced into the V2 region of gp120 during independent pathogenic simian immunodeficiency virus/HIV chimeric virus (SHIV) infections of rhe...
• Determination of a statistically valid neutralization titer in plasma that confers protection against simian-human immunodeficiency virus challenge following passive t...
• Evolution of a human immunodeficiency virus type 1 variant with enhanced replication in pig-tailed macaque cells by DNA shuffling.
• Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronous.
• One step forwards, one step back.

Schools

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• Newcastle University

• Royal Victoria Infirm

• Kings College Hospital

• University London Hammersmith Hospital

• Institute Clin Res Middlesex Hospital

• Johns Hopkins Hospital

• Peter Bent Brigham Hospital

Doctors Specialties

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• Internal Medicine

Accepted Insurances

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