Professor, Neurosurgery, University of Maryland School of Medicine
Neurosurgery
Dr. Marc J. Simard, MD
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Dr. Marc J. Simard is an expert in the field of Neurosurgery. He researched medicine at Creighton University School of Medicine. Creighton University School of Medicine is ranked 79 in research and 78 in primary care medicine He received 2 awards: "CMS Meaningful Use Stage 1 Certification" and "Fellow (FAANS)". Doctor Marc J. Simard, MD is a published doctor. He has 97 publications published. The most current publication "Increase in functional Ca2+ channels in cerebral smooth muscle with renal hypertension." He is registered with Medicare and accepts Medicare payments.
Publications
- Treatment of Edema Associated With IntraCerebral Hemorrhage.
- Letter by Woodworth and Simard Regarding Article, "Outcome Following Decompressive Hemicraniectomy for Malignant Cerebral Infarction: Ethical Considerations".
- Is Glibenclamide the New Cool in Cardiopulmonary Resuscitation?
- A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury.
- A novel method to study Cerebrospinal fluid dynamics in rats.
- Targeting secondary Injury in intracerebral haemorrhage--perihaematomal oedema.
- Angiogenesis induced by prenatal ischemia predisposes to periventricular Hemorrhage during postnatal mechanical ventilation.
- Mechanisms of Astrocyte-Mediated Cerebral Edema.
- Exposure of the thorax to a sublethal blast wave causes a hydrodynamic pulse that leads to perivenular inflammation in the Brain.
- Potential of glyburide to reduce intracerebral edema in Brain metastases.
- Treatment of cerebral Aneurysms-surgical clipping or endovascular coiling: the guiding principles.
- Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema.
- Complex N-glycosylation stabilizes surface expression of transient receptor potential melastatin 4b.
- Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke.
- Glibenclamide in Cerebral Ischemia and Stroke.
- Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage.
- MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord Injury.
- The Sur1-Trpm4 Channel in Spinal Cord Injury.
- Sulfonylurea Receptor 1 Expression in Human Cerebral Infarcts.
- Outcomes in Severe Middle Cerebral Artery Ischemic Stroke.
- Low-angle Vascular Access for Neurovascular Procedures Using the Arstasis AXERA Access Device.
- The Protective Effect of Glibenclamide in a Model of Hemorrhagic Encephalopathy of Prematurity.
- Induced and Sustained Hypernatremia for the Prevention and Treatment of Cerebral Edema Following Brain Injury.
- Continuous hyperosmolar therapy for traumatic Brain injury-associated cerebral edema: As good as it gets, or an iatrogenic secondary insult?
- Long-term outcome of Gamma Knife stereotactic radiosurgery for arteriovenous malformations graded by the Spetzler-Martin classification.
- The DECRA Trial and Decompressive Craniectomy in Diffuse Traumatic Brain Injury: Is Decompression Really Ineffective?
- Transient receptor potential melastatin 4 and cell death.
- The Effect of Apamin, a Small Conductance Calcium Activated Potassium (SK) Channel Blocker, on a Mouse Model of Neurofibromatosis 1.
- Sulfonylurea receptor 1 in central Nervous system injury: a focused review.
- Rodent Model of Direct Cranial Blast Injury.
- Letter by Simard et al Regarding Article, "Sulfonylurea Use Before Stroke Does Not Influence Outcome"
- Managing malignant Cerebral infarction.
- Increased transient receptor potential vanilloid type 1 (TRPV1) signaling in idiopathic overactive bladder urothelial cells.
- Unfractionated heparin: multitargeted therapy for delayed neurological deficits induced by subarachnoid Hemorrhage.
- Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic Brain injury.
- Molecular mechanisms of microvascular failure in central Nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4.
- Brief suppression of Abcc8 prevents autodestruction of spinal cord after Trauma.
- Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke.
- Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after Brain contusion.
- Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome.
- Novel model of frontal impact closed head Injury in the rat.
- Molecular mechanisms of ischemic Cerebral edema: role of electroneutral ion transport.
- Comparative study of decompressive craniectomy after mass lesion evacuation in severe head Injury.
- Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid Hemorrhage.
- Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke.
- De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord Injury.
- Sulfonylurea receptor 1 in the germinal matrix of premature infants.
- Glial fibrillary acidic protein is highly correlated with Brain injury.
- Plasma levels of the beta chemokine regulated upon activation, normal T cell expressed, and secreted (RANTES) correlate with severe Brain injury.
- Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke.
- Autocrine TGF-beta1 mediates angiotensin II-induced proliferative response of Cerebral vessels in vivo.
- Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord Injury.
- EGF and HB-EGF modulate inward potassium current in human bladder urothelial cells from Normal and interstitial cystitis patients.
- Cytotoxic edema: mechanisms of pathological cell swelling.
- Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes.
- Sphingolipids and transient receptor potential channels: evolutionarily ancient families now joined.
- Recommendations of the National Heart, Lung, and Blood Institute working group on Cerebrovascular biology and disease.
- Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates Cerebral edema after ischemic stroke.
- Concomitant GRID boost for Gamma Knife radiosurgery.
- Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytes.
- Suppression of ammonia-induced astrocyte swelling by cyclosporin A.
- Trans-cellular proliferating cell nuclear antigen gene activation in cerebral vascular smooth muscle by endothelial oxidative Injury in vivo.
- Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle.
- Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat Brain.
- Adenosine-A2a receptor down-regulates Cerebral smooth muscle L-type Ca2+ channel activity via protein tyrosine phosphatase, not cAMP-dependent protein kinase.
- Vascular smooth muscle proliferation as a target for therapeutic intervention.
- Concomitant boost of stratified target area with gamma knife radiosurgery: a treatment planning study.
- Chlorotoxin-sensitive Ca2+-activated Cl- channel in type R2 reactive astrocytes from adult rat Brain.
- Mislocalization of eNOS and upregulation of Cerebral vascular Ca2+ channel activity in angiotensin-hypertension.
- cGMP-dependent and not cAMP-dependent kinase is required for adenosine-induced dilation of intraCerebral arterioles.
- Increase in Cx45 gap junction channels in Cerebral smooth muscle cells from SHR.
- Fetal and ovarian radiation dose in patients undergoing gamma knife radiosurgery.
- Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat br...
- Reduced-dose radiosurgery for vestibular Schwannomas.
- Connexin45 gap junction channels in rat Cerebral vascular smooth muscle cells.
- Cell swelling and a nonselective cation channel regulated by internal Ca2+ and ATP in native reactive astrocytes from adult rat Brain.
- Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters.
- Chronic nicotine alters NO signaling of Ca(2+) channels in Cerebral arterioles.
- Inward rectifier K(+) channel Kir2.3 (IRK3) in reactive astrocytes from adult rat Brain.
- Anticoagulation in neurosurgical patients.
- K(+) inward rectifier currents in reactive astrocytes from adult rat Brain.
- Multiple connexins form gap junction channels in rat basilar Artery smooth muscle cells.
- Increase in functional Ca2+ channels in Cerebral smooth muscle with renal hypertension.
- The complement membrane attack complex and the bystander effect in Cerebral vasospasm.
- 4-Aminopyridine causes apoptosis and blocks an outward rectifier K+ channel in malignant Astrocytoma cell lines.
- Early signaling events by endotoxin in PC12 cells: involvement of tyrosine kinase, constitutive nitric oxide synthase, cGMP-dependent protein kinase, and Ca2+ channels.
- Radiosurgery for Cerebral arteriovenous malformations: assessment of early phase magnetic resonance imaging and significance of gadolinium-DTPA enhancement.
- Acetyl-L-carnitine arginyl amide (ST857) increases calcium channel density in rat pheochromocytoma (PC12) cells.
- The patch clamp technique.
- Intraarterial papaverine infusion for Cerebral vasospasm after subarachnoid hemorrhage.
- Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and Disease progression in experimental autoimmune encephalomyelitis.
- Glibenclamide for the Treatment of Acute CNS Injury.
- BRCA1 wild-type allele modifies risk of ovarian Cancer in carriers of BRCA1 germ-line mutations.
- Biochemical and electrophysiological characteristics of toxins isolated from the venom of the scorpion Centruroides sculpturatus.
- Spontaneous, rhythmic myoelectric activity induced by scorpion neurotoxin, reduced [calcium]0 and cadmium in chick striated muscle.
- Genetic variation at 9p22.2 and ovarian Cancer risk for BRCA1 and BRCA2 mutation carriers.
Schools
Creighton University
University FlShands HospampVet Adm Hospital
University SaarlandesPhysiol Institute
Procedures Preformed
- Cerebrospinal Fluid (CSF) Shunt - Insertion, Repair or Removal
- Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
- Disc Replacement
- Dural Repair or Other Spinal Spinal Cord Repair
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Conditions Treated
- Acoustic Neuroma
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Aneurysm
- Brain Cancer
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Doctors Specialties
- Neurosurgery
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Fellow (FAANS)
Education
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University of Florida -
Creighton University School of Medicine
Hospital
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University of Maryland Medical Center
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