Professor, Medicine, University of Washington School of Medicine

Infectious Disease

Margaret McElrath is an expert in the field of Infectious Disease. Dr. Margaret J. McElrath is a published doctor. She has 39 papers published. The most current publication "CXCL13 is a plasma biomarker of germinal center activity."

Publications

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• Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083.
• CXCL13 is a plasma biomarker of germinal center activity.
• T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents.
• Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.
• In men at risk of HIV infection, IgM, IgG1, IgG3, and IgA reach the human foreskin epidermis.
• Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals.
• HIV-1 Single-Stranded RNA Induces CXCL13 Secretion in Human Monocytes via TLR7 Activation and Plasmacytoid Dendritic Cell-Derived Type I IFN.
• HIV-1 integration landscape during latent and active infection.
• OMIP-024: Pan-leukocyte immunophenotypic characterization of PBMC subsets in human samples.
• Antiretroviral Pre-Exposure Prophylaxis Does Not Enhance Immune Responses to HIV in Exposed but Uninfected Persons.
• OMIP-025: Evaluation of human T- and NK-cell responses including memory and follicular helper phenotype by intracellular cytokine staining.
• Use of placebos in Phase 1 preventive HIV vaccine clinical trials.
• Phase I/II Randomized Trial of Safety and Immunogenicity of LIPO-5 Alone, ALVAC-HIV (vCP1452) Alone, and ALVAC-HIV (vCP1452) Prime/LIPO-5 Boost in Healthy, HIV-1 Uninf...
• Specificity and 6-Month Durability of Immune Responses Induced by DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-Like Particles.
• Optimization of a whole blood phenotyping assay for enumeration of peripheral blood leukocyte populations in multicenter clinical trials.
• Analysis of HLAA*02 association with vaccine efficacy in the RV144 HIV-1 vaccine trial.
• Benefits of a comprehensive quality program for cryopreserved PBMC covering 28 clinical trials sites utilizing an integrated, analytical web-based portal.
• One shot forward for HIV prevention.
• Long-term effect of depot medroxyprogesterone acetate on vaginal microbiota, epithelial thickness and HIV target cells.
• Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study.
• Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans.
• Increased Sequence Coverage through Combined Targeting of Variant and Conserved Epitopes Correlates with Control of HIV Replication.
• Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans.
• Measuring inhibition of HIV replication by ex vivo CD8(+) T cells.
• Human CD1a Deficiency Is Common and Genetically Regulated.
• Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus.
• Differential Regulatory T Cell Activity in HIV Type 1-Exposed Seronegative Individuals.
• HIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.
• Optimization and qualification of a memory B-cell ELISpot for the detection of vaccine-induced memory responses in HIV vaccine trials.
• OMIP-014: Validated multifunctional characterization of antigen-specific human T cells by intracellular cytokine staining.
• A Novel HIV Vaccine Adjuvanted by IC31 Induces Robust and Persistent Humoral and Cellular Immunity.
• Vpu deficient HIV strains stimulate innate immune signaling responses in target cells.
• Vpu mediates IRF3 depletion during HIV infection by a lysosomal-dependent mechanism.
• Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.
• HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis.
• Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scal...
• Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Reveals an Association of Nonspecific Interferon-γ Secretion with Increased HIV-1 Infection Risk: A Cohor...
• The Inner Foreskin of Healthy Males at Risk of HIV Infection Harbors Epithelial CD4+ CCR5+ Cells and Has Features of an Inflamed Epidermal Barrier.

Schools

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• Medical University of South Carolina

• Med University Sc Affil Hospital

• Colum Presby Hospital

Doctors Specialties

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• Infectious Disease Medicine
• Infectious Disease

Accepted Insurances

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