Physician
Internal Medicine
Dr. Mark Hahn, MD
Mark Hahn works in the field of Internal Medicine. He researched medicine at Drexel University College of Medicine. Mark Hahn is a published doctor. He has 99 papers published. The most current publication "The aryl hydrocarbon receptor: a comparative perspective."
Publications
- Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio).
- Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus).
- In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.
- Knockdown of a Zebrafish Aryl Hydrocarbon Receptor Repressor (AHRRa) Affects Expression of Genes Related to Photoreceptor Development and Hematopoiesis.
- Species-specific relative AHR1 binding affinities of 2,3,4,7,8-pentachlorodibenzofuran explain avian species differences in its relative potency.
- Aryl hydrocarbon receptor (AHR) in the cnidarian Nematostella vectensis: comparative expression, protein interactions, and ligand binding.
- Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio).
- The African coelacanth genome provides insights into tetrapod evolution.
- Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus).
- Specific Ligand Binding Domain Residues Confer Low Dioxin Responsiveness to AHR1? of Xenopus laevis.
- Amino acid sequence of the ligand-binding domain of the aryl hydrocarbon receptor 1 predicts sensitivity of wild birds to effects of dioxin-like compounds.
- The Transcriptional Response to Oxidative Stress during Vertebrate Development: Effects of tert-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.
- Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats.
- Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production.
- Developmental exposure to valproic acid alters the expression of microRNAs involved in neurodevelopment in zebrafish.
- Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio.
- Issues in the genetics of social behavior: revisited.
- Genetic analysis of cerebellar foliation patterns in mice (Mus musculus).
- Genetic analyses of the biphasic nature of the alcohol dose-response curve.
- Development of a gel-simulation model and generation of standard tables for the complete extirpation of benign breast lesions with vacuum assisted biopsy under ultraso...
- A diallel analysis of brain and body weight in male inbred laboratory mice (Mus musculus).
- Genetic and developmental influences on infant mouse ultrasonic calling. II. Developmental patterns in the calls of mice 2-12 days of age.
- The effects of prenatal cocaine exposure and genotype on the ultrasonic calls of infant mice.
- Issues in the genetics of social behavior.
- Genetic selection disrupts stability of mouse brain weight development.
- Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models.
- Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isozymes in the rat.
- Determination of individual porphyrins in rodent urine using high-performance liquid chromatography following clean-up by anion-exchange chromatography.
- A fish hepatoma cell line (PLHC-1) as a tool to study cytotoxicity and CYP1A induction properties of cellulose and wood chip extracts.
- The aryl hydrocarbon receptor: a comparative perspective.
- Biological activity and physicochemical parameters of marine halogenated natural products 2,3,3'',4,4'',5,5''-heptachloro-1''-methyl-1,2''-bipyrrole and 2,4,6-tribromo...
- Cytochrome P4501A induction and porphyrin accumulation in PLHC-1 fish cells exposed to sediment and oil shale extracts.
- The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice.
- The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome.
- Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P450 1A in agnathan and elasmobranch fish.
- An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin...
- Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic...
- Consensus statement: Atlantic Coast Contaminants Workshop 2000.
- Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor ...
- Effects of ortho- and non-ortho-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops).
- Halogenated aromatic hydrocarbon-mediated porphyrin accumulation and induction of cytochrome P4501A in chicken embryo hepatocytes.
- Immunohistochemical localization of cytochrome P-450IA1 induced by 3,3',4,4'-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tiss...
- Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhi...
- Two forms of aryl hydrocarbon receptor type 2 in rainbow trout (Oncorhynchus mykiss). Evidence for differential expression and enhancer specificity.
- Immunohistochemical localization of environmentally induced cytochrome P450IA1 in multiple organs of the marine teleost Stenotomus chrysops (Scup).
- Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species.
- Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlo...
- Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family.
- Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness.
- Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro stud...
- Identification and functional characterization of two highly divergent aryl hydrocarbon receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a ...
- The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis.
- In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P...
- Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency.
- Developmental and tissue-specific expression of AHR1, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish Fundulus heteroclitus.
- The bioflavonoid galangin blocks aryl hydrocarbon receptor activation and polycyclic aromatic hydrocarbon-induced pre-B cell apoptosis.
- Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays.
- Functional diversity of vertebrate ARNT proteins: identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus.
- Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction ...
- Catalytic and immunochemical characterization of hepatic microsomal cytochromes P450 in beluga whale (Delphinapterus leucas).
- Regulation of cytochrome P4501A1 in teleosts: sustained induction of CYP1A1 mRNA, protein, and catalytic activity by 2,3,7,8-tetrachlorodibenzofuran in the marine fish...
- Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells.
- Evolutionary conservation of the vertebrate Ah (dioxin) receptor: amplification and sequencing of the PAS domain of a teleost Ah receptor cDNA.
- cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas.
- Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian.
- The evolution of aryl hydrocarbon signaling proteins: diversity of ARNT isoforms among fish species.
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos.
- The genome of the sea urchin Strongylocentrotus purpuratus.
- Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics.
- Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2.
- The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon receptor.
- Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fu...
- Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo.
- The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells.
- AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes.
- Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics.
- Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus).
- Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus).
- Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories.
- Naturally produced halogenated dimethyl bipyrroles bind to the aryl hydrocarbon receptor and induce cytochrome P4501A and porphyrin accumulation in chicken embryo hepa...
- Gonadal feminization and halogenated environmental contaminants in common terns (Sterna hirundo): evidence that ovotestes in male embryos do not persist to the prefled...
- A ligand for the aryl hydrocarbon receptor isolated from lung.
- cDNA cloning of an aryl hydrocarbon receptor from Baikal seals (Phoca sibirica).
- Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs).
- Aryl hydrocarbon receptors: diversity and evolution.
- The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 is a novel vertebrate receptor.
- Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics.
- cDNA cloning and characterization of an aryl hydrocarbon receptor from the harbor seal (Phoca vitulina): a biomarker of dioxin susceptibility?
- Biomarkers and bioassays for detecting dioxin-like compounds in the marine environment.
- Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cells.
- Serum withdrawal leads to reduced aryl hydrocarbon receptor expression and loss of cytochrome P4501A inducibility in PLHC-1 cells.
- Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two...
- Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2).
- Mechanistic research in aquatic toxicology: perspectives and future directions.
- Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine...
- Reduced cytochrome P4501A activity and recovery from oxidative stress during subchronic benzo[a]pyrene and benzo[e]pyrene treatment of rainbow trout.
- Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.
- Cytochrome P450 diversity and induction by gorgonian allelochemicals in the marine gastropod Cyphoma gibbosum.
Schools
Drexel University College of Medicine
Exempla St Joseph Hospital
University Of Nv School Of Med
Doctors Specialties
- Internal Medicine
Accepted Insurances
Education
-
University of Nevada, Reno -
Exempla St Joseph Hospital -
Drexel University College of Medicine
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