Physician
Cardiology
Dr. Michael N. Sack, MD
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Michael Sack is an expert in the field of Cardiology. He over the years received 1 awards: "Elected Member". Michael Sack is a published doctor as well. He has 88 publications published. The latest was: The energy substrate switch during development of heart failure: gene regulatory mechanisms (Review).
Publications
- Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury.
- Regulation of autophagy and mitophagy by nutrient availability and acetylation.
- GCN5-like Protein 1 (GCN5L1) Controls Mitochondrial Content through Coordinated Regulation of Mitochondrial Biogenesis and Mitophagy.
- Restricted mitochondrial protein acetylation initiates mitochondrial autophagy.
- The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
- Mitochondrial metabolism, sirtuins, and aging.
- Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease.
- The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging.
- The role of sirtuins in modulating redox stressors.
- Emerging characterization of the role of SIRT3 mediated mitochondrial protein deacetylation in the heart.
- Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore.
- Mitofusin function is dependent on the distinct tissue and organ specific roles of mitochondria.
- New horizons in cardioprotection: recommendations from the 2010 national heart, lung, and blood institute workshop.
- Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.
- The role of comorbidities in cardioprotection.
- PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition.
- SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.
- Caloric Restriction in Leptin Deficiency Does Not Correct Myocardial Steatosis: Failure to Normalize PPAR{alpha}/PGC1{alpha} and Thermogenic Glyecrolipid/Fatty Acid Cy...
- Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS).
- Caloric excess or restriction mediated modulation of metabolic enzyme acetylation-proposed effects on cardiac growth and function.
- Ambient oxygen promotes tumorigenesis.
- Wnt signaling regulates hepatic metabolism.
- PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition.
- Mitochondrial Fe-S cluster biogenesis, frataxin and the modulation of susceptibility to drug-induced cardiomyopathy.
- SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity.
- Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 is...
- The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance.
- The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology.
- Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis.
- ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3.
- PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle.
- A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitus.
- Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide.
- Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer.
- The regulation, control, and consequences of mitochondrial oxygen utilization and disposition in the heart and skeletal muscle during hypoxia.
- Exploring mitochondria in the intact ischemic heart: advancing technologies to image intracellular function.
- Ceramide attenuates hypoxic cell death via reactive oxygen species signaling.
- Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia.
- H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recovery and reduces infarct size.
- The mitochondrial biogenesis regulatory program in cardiac adaptation to ischemia--a putative target for therapeutic intervention.
- Delayed ischemic preconditioning activates nuclear-encoded electron-transfer-chain gene expression in parallel with enhanced postanoxic mitochondrial respiratory recov...
- p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling.
- Hypoxia-induced decrease of UCP3 gene expression in rat heart parallels metabolic gene switching but fails to affect mitochondrial respiratory coupling.
- Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulation.
- Renal transplantation despite a positive antiglobulin crossmatch with and without prophylactic OKT3.
- Efficacy of plant-produced recombinant antibodies against HCG.
- Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies.
- Effects of long-acting nifedipine on casual office blood pressure measurements, 24-hour ambulatory blood pressure profiles, exercise parameters and left ventricular ma...
- Apoptosis: a pivotal event or an epiphenomenon in the pathophysiology of heart failure?
- Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women.
- Tumor necrosis factor-alpha in cardiovascular biology and the potential role for anti-tumor necrosis factor-alpha therapy in heart disease.
- The energy substrate switch during development of heart failure: gene regulatory mechanisms (Review).
- Phase I/II trial of recombinant methionyl human tumor necrosis factor binding protein PEGylated dimer in patients with active refractory rheumatoid arthritis.
- A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.
- Fatty acid oxidation enzyme gene expression is downregulated in the failing heart.
- Enhanced angiotensin II activity in heart failure: reevaluation of the counterregulatory hypothesis of receptor subtypes.
- Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia.
- [Sphingolipid signaling: a potential pathway for TNF-alpha induced preconditioning].
- Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism.
- Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection.
- Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling.
- Tumor necrosis factor in myocardial hypertrophy and ischaemia--an anti-apoptotic perspective.
- Coordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy in spontaneously hypertensive rats.
- Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle.
- Mechanisms whereby glucose deprivation triggers metabolic preconditioning in the isolated rat heart.
- TNF alpha is required for hypoxia-mediated right ventricular hypertrophy.
- Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling.
- Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning.
- Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene.
- Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective program.
- Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection.
- Counter-regulatory effects of incremental hypoxia on the transcription of a cardiac fatty acid oxidation enzyme-encoding gene.
- Mitochondrial plasticity in classical ischemic preconditioning-moving beyond the mitochondrial KATP channel.
- Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning.
- PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve--a putative mechanism in PKCepsilon cardioprotection.
- Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance.
- Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion.
- Targeting the mitochondria to augment myocardial protection.
- The regulation and control of mitochondrial homeostasis in changing cardiac tolerance to ischemia-reperfusion injury: a focused issue.
- Type 2 diabetes, mitochondrial biology and the heart.
- SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells.
- Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1.
- Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.
- Rab4a signaling unmasks a pivotal link between myocardial homeostasis and metabolic remodeling in the diabetic heart.
- Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors.
- TNFα protects cardiac mitochondria independently of its cell surface receptors.
- Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning.
Schools
University of The WitwatersrandFaculty of Health Sciences
Georgetown University Med Center
Barnes Jewish Hospital
Doctors Specialties
- Internal Medicine
- Cardiology
Accepted Insurances
Awards
- Elected Member
Education
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Washington University - Barnes-Jewish Hospital -
Georgetown University Hospital -
University of the Witwatersrand
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1639100076 |
| Last Name Of The Provider | SACK |
| First Name Of The Provider | MICHAEL |
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