Professor, Surgery, University of California Los Angeles David Geffen SOM
General Surgery
Dr. Mitchell P. Fink, MD
Mitchell Fink practices General Surgery. He researched medicine at Washington University School of Medicine in St. Louis. He received awards:"Fellow (FCCM)" and "Fellow". Mitchell Fink is also a published doctor. He has 101 paper published. The most recent paper is: THE EPITHELIUM AS A TARGET IN SEPSIS. Mitchell Fink is registered with Medicare and accepts Medicare payments.
Publications
- THE EPITHELIUM AS A TARGET IN SEPSIS.
- Successful Use of Extracorporeal Membrane Oxygenation in an Adult Patient With Toxic Shock-Induced Heart Failure.
- Strategies to improve drug development for sepsis.
- Matrix metalloproteinase-8 as a potential drug target for the therapy of sepsis*.
- A comparison of critical care research funding and the financial burden of critical illness in the United States.
- l-Arginine is a Radioprotector for Hematopoietic Progenitor Cells.
- TRANSCRIPTOMIC RESPONSE OF MURINE LIVER TO SEVERE INJURY AND HEMORRHAGIC SHOCK: A DUAL PLATFORM MICROARRAY ANALYSIS.
- Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb...
- Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion.
- The therapeutic potential of pyruvate.
- Preconditioning with high mobility group box 1 (HMGB1) induces lipoteichoic acid (LTA) tolerance.
- Editorial: Lepromatous leprosy, lipids, and lessons in immunology: what we can learn by using modern methods to study an ancient disease.
- Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis.
- Sepsis, ghrelin, the cholinergic anti-inflammatory pathway, gut mucosal hyperpermeability, and high-mobility group box 1.
- Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury.
- Editorial: Hemopexin: newest member of the anti-inflammatory mediator club.
- Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia.
- Peroxisome proliferator activator receptor gamma (PPARgamma) agonists as therapeutic adjuncts in critical illness: efficacy might be suboptimal in elderly patients.
- A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass.
- Ethyl pyruvate ameliorates liver injury secondary to severe acute pancreatitis.
- Drag-reducing hyaluronic acid increases survival in profoundly hemorrhaged rats.
- Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice.
- Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance.
- Animal models of sepsis and its complications.
- Neuropeptide modulators of high mobility group box 1 secretion as potential therapeutic agents for severe sepsis.
- Ethyl pyruvate.
- Targeting mitochondria.
- Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation.
- Systemic inflammation and remote organ injury following trauma require HMGB1.
- Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants.
- Administration of exogenous cytochrome c as a novel approach for the treatment of cytopathic hypoxia.
- Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides.
- Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock.
- A single intraperitoneal dose of carbon monoxide-saturated ringer's lactate solution ameliorates postoperative ileus in mice.
- The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis.
- LPS increases hepatic HIF-1alpha protein and expression of the HIF-1-dependent gene aldolase A in rats.
- The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock.
- Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4.
- In silico models of acute inflammation in animals.
- Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury.
- The future of our specialty: critical care medicine a decade from now.
- In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice.
- Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock.
- Intensive care and emergency medicine: progress over the past 25 years.
- HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers.
- The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells.
- Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock.
- The prevention and treatment of sepsis: is interleukin-6 a drug target or a drug?
- Molecular biology for today's practicing intensivist.
- Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates.
- Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice.
- The multiple organ dysfunction syndrome and late-phase mortality in sepsis.
- Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia.
- What do insulin, estrogen, valproic acid, and TDZD-8 have in common?
- The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock.
- Challenge and rechallenge: drotrecogin alfa (activated)-induced prolongation of activated partial thromboplastin time in a patient with severe sepsis.
- The acute inflammatory response in diverse shock states.
- Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism.
- The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion.
- Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level.
- Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65.
- Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis.
- Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients.
- Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway.
- Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis.
- Research: advances in cell biology relevant to critical illness.
- Survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a drag-reducing polymer derived f...
- Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis.
- Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice.
- Peroxisome proliferator-activated receptor-gamma ligands: a pluripotent class of pharmacological agents that may prove to be useful for adjuvant treatment of sepsis an...
- Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice.
- Reversing established sepsis with antagonists of endogenous high-mobility group box 1.
- Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 ...
- Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice.
- The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States.
- Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction.
- Red blood cell physiology in critical illness.
- Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion.
- Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice.
- NAD+ ameliorates inflammation-induced epithelial barrier dysfunction in cultured enterocytes and mouse ileal mucosa.
- Protective efficacy of CAP18106-138-immunoglobulin G in sepsis.
- IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice.
- Nuclear factor-kappaB: is it a therapeutic target for the adjuvant treatment of sepsis?
- Anemia and blood transfusion in trauma patients admitted to the intensive care unit.
- Critical care training for emergency physicians.
- Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26...
- Ringer's ethyl pyruvate solution: a novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis.
- Intestinal epithelial hyperpermeability: update on the pathogenesis of gut mucosal barrier dysfunction in critical illness.
- Proinflammatory cytokines increase the rate of glycolysis and adenosine-5'-triphosphate turnover in cultured rat enterocytes.
- Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes.
- Proinflammatory cytokines cause NO*-dependent and -independent changes in expression and localization of tight junction proteins in intestinal epithelial cells.
- Ethyl pyruvate: a novel anti-inflammatory agent.
- Structural basis for the proinflammatory cytokine activity of high mobility group box 1.
- Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers.
- Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccha...
- Effect of hemorrhagic shock on gut barrier function and expression of stress-related genes in normal and gnotobiotic mice.
- Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.
- One good turn deserves another!
- HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice.
- Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock.
Schools
Washington University St Louis
National Naval Med Center
Doctors Specialties
- Critical Care Surgery
- General Surgery
Accepted Insurances
Awards
- Fellow (FCCM)
- Fellow
Education
-
National Capital Consortium -
Washington University School of Medicine in St. Louis
Hospital
-
Ronald Reagan UCLA Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1750354940 |
| Last Name Of The Provider | FINK |
| First Name Of The Provider | MITCHELL |
| View All |
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