Professor of Molecular and Human Genetics, Baylor College of Medicine
Endocrinology
Dr. Olivier Lichtarge, MD
Doctor Olivier Lichtarge, MD is an expert in the field of Endocrinology. He researched medicine at Stanford University School of Medicine. Stanford University School of Medicine is one of the top medical schools in the US. Stanford University School of Medicine is ranked 2 in research and 25 in primary care medicine Olivier Lichtarge is a published doctor and has 98 publications published. The lastest was: 'The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation.'
Publications
- UET: a database of evolutionarily-predicted functional determinants of protein sequences that cluster as functional sites in protein structures.
- Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.
- Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients.
- Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors.
- Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.
- A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness.
- Single nucleotide variations: Biological impact and theoretical interpretation.
- Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence.
- Negative Feedback in Genetic Circuits Confers Evolutionary Resilience and Capacitance.
- Prediction and redesign of protein-protein interactions.
- Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.
- Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues.
- The Maternal-to-Zygotic Transition Targets Actin to Promote Robustness during Morphogenesis.
- Prediction and experimental validation of enzyme substrate specificity in protein structures.
- Accounting for epistatic interactions improves the functional analysis of protein structures.
- Protein Kinase A and Phosphodiesterase-4D3 Binding to Coding Polymorphisms of Cardiac Muscle Anchoring Protein (mAKAP).
- Function prediction from networks of local evolutionary similarity in protein structure.
- An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders.
- Identification of a candidate therapeutic autophagy-inducing peptide.
- A large-scale evaluation of computational protein function prediction.
- Identity and function of a large gene network underlying mutagenic repair of DNA breaks.
- The use of evolutionary patterns in protein annotation.
- Getting past appearances: the many-fold consequences of remote homology.
- Prediction and confirmation of a site critical for effector regulation of RGS domain activity.
- Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function.
- Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes.
- A genome-wide search for synaptic vesicle cycle proteins in Drosophila.
- A regulator of G protein signaling interaction surface linked to effector specificity.
- Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activat...
- C5a receptor activation. Genetic identification of critical residues in four transmembrane helices.
- The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation.
- Identification of functional surfaces of the zinc binding domains of intracellular receptors.
- Meeting review: the Second meeting on the Critical Assessment of Techniques for Protein Structure Prediction (CASP2), Asilomar, California, December 13-16, 1996.
- Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin.
- Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.
- Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.
- An evolutionary trace method defines binding surfaces common to protein families.
- Some model experiments in hemodynamics: VI. Two-body collisions between blood cells.
- Validation of the first step of the heuristic refinement method for the derivation of solution structures of proteins from NMR data.
- Secondary structure determination of human beta-endorphin by 1H NMR spectroscopy.
- The structure of proteins and their binding sites: NMR and artificial intelligence.
- Combining inference from evolution and geometric probability in protein structure evaluation.
- A family of evolution-entropy hybrid methods for ranking protein residues by importance.
- An evolution based classifier for prediction of protein interfaces without using protein structures.
- Evolutionary and structural feedback on selection of sequences for comparative analysis of proteins.
- A structure and evolution-guided Monte Carlo sequence selection strategy for multiple alignment-based analysis of proteins.
- On itinerant water molecules and detectability of protein-protein interfaces through comparative analysis of homologues.
- Sequence and structure continuity of evolutionary importance improves protein functional site discovery and annotation.
- Background frequencies for residue variability estimates: BLOSUM revisited.
- Evolutionary trace report_maker: a new type of service for comparative analysis of proteins.
- Role of transmembrane domain/transmembrane domain interfaces of P-glycoprotein (ABCB1) in solute transport. Convergent information from photoaffinity labeling, site di...
- Evolutionary trace for prediction and redesign of protein functional sites.
- Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites.
- Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature.
- Protein function prediction: towards integration of similarity metrics.
- Accurate protein structure annotation through competitive diffusion of enzymatic functions over a network of local evolutionary similarities.
- Molecular defects in human carbamoy phosphate synthetase I: mutational spectrum, diagnostic and protein structure considerations.
- PyETV: a PyMOL evolutionary trace viewer to analyze functional site predictions in protein complexes.
- Graph sharpening plus graph integration: a synergy that improves protein functional classification.
- Composite motifs integrating multiple protein structures increase sensitivity for function prediction.
- The MASH pipeline for protein function prediction and an algorithm for the geometric refinement of 3D motifs.
- Cavity scaling: automated refinement of cavity-aware motifs in protein function prediction.
- Evolution: a guide to perturb protein function and networks.
- Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors.
- An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis.
- Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.
- Evolutionary trace annotation of protein function in the structural proteome.
- Mitochondrial neurogastrointestinal encephalopathy due to mutations in RRM2B.
- Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones.
- Evolutionary Trace Annotation Server: automated enzyme function prediction in protein structures using 3D templates.
- Identification of functionally important residues/domains in membrane proteins using an evolutionary approach coupled with systematic mutational analysis.
- De-orphaning the structural proteome through reciprocal comparison of evolutionarily important structural features.
- Prediction of enzyme function based on 3D templates of evolutionarily important amino acids.
- Cavity-aware motifs reduce false positives in protein function prediction.
- Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions.
- Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis.
- Rapid detection of similarity in protein structure and function through contact metric distances.
- Rank information: a structure-independent measure of evolutionary trace quality that improves identification of protein functional sites.
- Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptors.
- ET viewer: an application for predicting and visualizing functional sites in protein structures.
- Recurrent use of evolutionary importance for functional annotation of proteins based on local structural similarity.
- beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
- Character and evolution of protein-protein interfaces.
- Evolutionary trace-based peptides identify a novel asymmetric interaction that mediates oligomerization in nuclear receptors.
- Correlated evolutionary pressure at interacting transcription factors and DNA response elements can guide the rational engineering of DNA binding specificity.
- Algorithms for structural comparison and statistical analysis of 3D protein motifs.
- Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.
- Evolution of neural precursor selection: functional divergence of proneural proteins.
- Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions.
- Accurate and scalable identification of functional sites by evolutionary tracing.
- Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1.
- An accurate, sensitive, and scalable method to identify functional sites in protein structures.
- Lysine 270 in the third intracellular domain of the oxytocin receptor is an important determinant for G alpha(q) coupling specificity.
- Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man.
- Evolutionary predictions of binding surfaces and interactions.
- Structural clusters of evolutionary trace residues are statistically significant and common in proteins.
- Evolutionary traces of functional surfaces along G protein signaling pathway.
Schools
Stanford University
Doctors Specialties
- Endocrinology
Accepted Insurances
Education
-
Stanford University School of Medicine
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