Physician
Medical Genetics
Dr. Ophir D. Klein, MD
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Dr. Ophir D. Klein is an expert in the field of Medical Genetics. He researched medicine at Yale University School of Medicine. Yale University School of Medicine is a top medical university. Yale University School of Medicine has a rank of 7 in research and a 57 in primary care He received awards:"Fellow (FAAP)". Ophir D. Klein, MD is a published doctor and has 62 publications published. The lastest was: 'Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways.'
Publications
- Craniofacial Stem Cells in Health and Disease.
- Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster).
- Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis.
- Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia.
- Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.
- The WNT10A gene in ectodermal dysplasias and selective tooth agenesis.
- Dental findings in 14q terminal deletion syndrome.
- Craniofacial and dental development in Costello syndrome.
- On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells.
- Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor.
- Tooth, hair and claw: Comparing epithelial stem cell niches of ectodermal appendages.
- Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.
- Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy.
- Abnormal Ras Signaling in Costello Syndrome (CS) Negatively Regulates Enamel Formation.
- The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.
- The society of craniofacial genetics and developmental biology 35th annual meeting.
- BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.
- Characterization of X-linked Hypohidrotic Ectodermal Dysplasia (XL-HED) Hair and Sweat Gland Phenotypes Using Phototrichogram Analysis and Live Confocal Imaging.
- From molecules to mastication: the development and evolution of teeth.
- Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis.
- Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells.
- Stem cell and biomaterials research in dental tissue engineering and regeneration.
- Characterization of Dental Epithelial Stem Cells from the Mouse Incisor with 2D and 3D Platforms.
- FGF Signaling Regulates the Number of Posterior Taste Papillae by Controlling Progenitor Field Size.
- Expression of MicroRNAs in the Stem Cell Niche of the Adult Mouse Incisor.
- Clefting in trisomy 9p patients: genotype-phenotype correlation using microarray comparative genomic hybridization.
- Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice.
- Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis.
- Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male.
- Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling.
- Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization.
- Brachydactylic multiple delta phalanges plus syndrome.
- From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models.
- Developing and regenerating a sense of taste.
- Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor.
- Inductive ability of human developing and differentiated dental mesenchyme.
- Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates.
- Dandy-Walker malformation: prenatal diagnosis and prognosis.
- Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways.
- The spun micro-haematocrit and mean red cell volume are affected by changes in the oxygenation state of red blood cells.
- Quality of Life, Sustainable Future and medical education.
- Genomic variants of ATF3 in patients with hypospadias.
- Mutations of CXorf6 are associated with a range of severities of hypospadias.
- Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors.
- Patterning by heritage in mouse molar row development.
- Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition.
- Genotype-phenotype analysis of the branchio-oculo-facial syndrome.
- Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization.
- Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH.
- Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor.
- Case report: Y;6 translocation with deletion of 6p.
- The branching programme of mouse lung development.
- An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.
- Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches.
- Dact1-3 mRNAs exhibit distinct expression domains during tooth development.
- Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.
- Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors.
- PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
- A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.
- Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
- Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning.
Schools
Yale University School Of Medicine
Doctors Specialties
- Clinical Genetics
- Pediatrics
- Medical Genetics
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- Advantage Preferred DirectAccess Plus PPO
- Blue Cross Blue Shield of California PPO
- Pathway X Direct Access PPO
- Pathway X Tiered Direct Access
- Select PPO
- Access Plus Savenet
- Enhanced Exclusive for Small Business HMO
- Local Access Plus HMO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- First Health (Coventry Health Care) PPO
- Blue & Gold HMO
- Covered California - Bronze PPO
- Employer Group HMO
- Health Net PPO
- Individual and Family PPO
- WholeCare Network HMO
- Heritage Signature
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- PacifiCare HMO
Awards
- Fellow (FAAP)
Education
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Yale-New Haven Hospital -
Yale University School of Medicine
Hospital
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UCSF Medical Center
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