Marshall K. Bartlett Professor of Surgery, Massachusetts General Hospital
General Surgery
Dr. Patricia K. Donahoe, MD
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Patricia Donahoe practices General Surgery. He researched medicine at Columbia University College of Physicians & Surgeons. Columbia University College of Physicians & Surgeons is a top medical university. Columbia University College of Physicians & Surgeons is ranked 8 in research and 52 in primary care medicine He received 3 awards: "Elected Member", "Whos Who in Medicine and Healthcare" and "Fellow (FACS)". Patricia Donahoe is a published doctor. He published 62 publications, including: 'Mllerian inhibiting substance/anti-Mllerian hormone: A novel treatment for gynecologic tumors.'
Publications
- Müllerian inhibiting substance/anti-Müllerian hormone: A novel treatment for gynecologic tumors.
- Prevalence and Penetrance of ZFPM2 Mutations and Deletions causing Congenital Diaphragmatic Hernia.
- Induction of WNT inhibitory factor 1 expression by Müllerian inhibiting substance/antiMullerian hormone in the Müllerian duct mesenchyme is linked to Müllerian duct re...
- An albumin leader sequence coupled with a cleavage site modification enhances the yield of recombinant C-terminal Mullerian Inhibiting Substance.
- Congenital diaphragmatic hernia interval on chromosome 8p23.1 characterized by genetics and protein interaction networks.
- Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development.
- Mullerian Inhibiting Substance Induces Apoptosis of Human Endometrial Stromal Cells in Endometriosis.
- Identification of characteristic molecular signature of Müllerian inhibiting substance in human HPV-related cervical cancer cells.
- Mullerian inhibiting substance inhibits invasion and migration of epithelial cancer cell lines.
- Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants.
- Müllerian inhibiting substance is anterogradely transported and does not attenuate avulsion-induced death of hypoglossal motor neurons.
- Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics.
- Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH.
- Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme.
- Development of an efficiently cleaved, bioactive, highly pure FLAG-tagged recombinant human Mullerian Inhibiting Substance.
- Uterine leiomyomas exhibit fewer stem/progenitor cell characteristics when compared with corresponding normal myometrium.
- HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.
- A pediatric surgeon retools in genetics and genomics to study congenital diaphragmatic hernia.
- Cell migration and activated PI3K/AKT-directed elongation in the developing rat Müllerian duct.
- Genetic tools and algorithms for gene discovery in major congenital anomalies.
- A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes.
- Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics.
- Donnai-Barrow syndrome (DBS/FOAR) in a child with a homozygous LRP2 mutation due to complete chromosome 2 paternal isodisomy.
- The mandate for innovation in pediatric surgery; creating the environment for success, parity, and excellence.
- c-Jun N-terminal kinase inhibitor II (SP600125) activates Mullerian inhibiting substance type II receptor-mediated signal transduction.
- Retinoic acid-mediated differentiation protects against nitrofen-induced apoptosis.
- Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes.
- Sexual dimorphism of G-protein subunit Gng13 expression in the cortical region of the developing mouse ovary.
- Congenital diaphragmatic hernia (CDH) etiology as revealed by pathway genetics.
- Adult mouse myometrial label-retaining cells divide in response to gonadotropin stimulation.
- Mullerian-inhibiting substance induces Gro-beta expression in breast cancer cells through a nuclear factor-kappaB-dependent and Smad1-dependent mechanism.
- Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer.
- Mullerian inhibiting substance regulates androgen-induced gene expression and growth in prostate cancer cells through a nuclear factor-kappaB-dependent Smad-independen...
- Expression analysis and evolutionary conservation of the mouse germ cell-specific D6Mm5e gene.
- Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness.
- Intersex genetic anomalies with malignant potential.
- Genomic approaches to surgical diseases: 21st annual Samuel Jason Mixter lecture.
- Recombinant human Mullerian inhibiting substance inhibits long-term growth of MIS type II receptor-directed transgenic mouse ovarian cancers in vivo.
- Conditional deletion of beta-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium.
- Mullerian inhibiting substance acts as a motor neuron survival factor in vitro.
- Infants with Bochdalek diaphragmatic hernia: sibling precurrence and monozygotic twin discordance in a hospital-based malformation surveillance program.
- Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance.
- Management and long-term follow-up of patients with types III and IV laryngotracheoesophageal clefts.
- Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-2004. A 23-day-old infant with hypospadias and failure to thrive.
- Sustained inquiry: in the clinic and at the bench.
- Detection of large-scale variation in the human genome.
- Müllerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation.
- Feedback inhibition of steroidogenic acute regulatory protein expression in vitro and in vivo by androgens.
- Sex determination and differentiation.
- The immunophilin FKBP12: a molecular guardian of the TGF-beta family type I receptors.
- Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.
- Mullerian inhibiting substance promotes interferon gamma-induced gene expression and apoptosis in breast cancer cells.
- Persistent Mullerian duct syndrome caused by both a 27-bp deletion and a novel splice mutation in the MIS type II receptor gene.
- Congenital adrenal hyperplasia: surgical considerations required to repair a 46,XX patient raised as a boy.
- The role of Müllerian inhibiting substance in the evaluation of phenotypic female patients with mild degrees of virilization.
- Müllerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line in...
- Highly purified müllerian inhibiting substance inhibits human ovarian cancer in vivo.
- Measurement of Mullerian inhibiting substance facilitates management of boys with microphallus and cryptorchidism.
- MEK-1/2 inhibition reduces branching morphogenesis and causes mesenchymal cell apoptosis in fetal rat lungs.
- Mullerian-inhibiting substance regulates NF-kappa B signaling in the prostate in vitro and in vivo.
- Mullerian inhibiting substance: an update.
Schools
Columbia University College of Physicians And Surgeons
Tufts New England Center Hospital
Children39s Hospital Boston
Massachusetts General Hospital
Alder Rey Children39s Hospital Eng
Children39s Hospital Harvard
Mass General Hospital Harvard
Doctors Specialties
- Pediatric Surgery
- General Surgery
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- GHI PPO
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- MultiPlan PPO
- PHCS Network PPO
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
- Fellow (FACS)
Education
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Massachusetts General Hospital -
Boston Children's Hospital -
Tufts Medical Center -
Columbia University College of Physicians & Surgeons
Hospital
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Massachusetts General Hospital
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