Physician

Orthopaedic Surgery

Patrick Casey is an expert in the field of Orthopaedic Surgery. He graduated from Geisel School of Medicine at Dartmouth. Geisel School of Medicine at Dartmouth has a rank of 37 in research and a 29 in primary care He over the years received 1 awards: "CMS Meaningful Use Stage 1 Certification". Patrick J. Casey, MD is also a published doctor. He has 102 paper published. The most recent paper is: Effects of cryopreservation on bull sperm head morphometry. Dr. Patrick J. Casey accepts Medicare.

Publications

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• Gαz regulates BDNF-induction of axon growth in cortical neurons.
• The involvement of growth hormone in equine oocyte maturation, receptor localization and steroid production by cumulus-oocyte complexes in vitro.
• Control of RhoA methylation by carboxylesterase I.
• A Role for the Rac3 GTPase in Autophagy Regulation.
• The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes.
• Prenylated C17ORF37 induces filopodia formation to promote cell migration and metastasis.
• Site-specific analysis of protein S-acylation by resin-assisted capture.
• G12 Signaling through c-Jun NH(2)-Terminal Kinase Promotes Breast Cancer Cell Invasion.
• RHO methylation matters: a role for isoprenylCysteine carboxylmethyltransferase in cell migration and adhesion.
• Amino derivatives of indole as potent inhibitors of isoprenylCysteine carboxyl methyltransferase.
• A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.
• The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion.
• Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
• Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
• Role of isoprenylCysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.
• PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion.
• Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and ...
• Activation of Rap1 promotes prostate cancer metastasis.
• Topology of mammalian isoprenylCysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.
• Interacting targets of the farnesyl of transducin gamma-subunit.
• A small molecule inhibitor of isoprenylCysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells.
• Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork.
• Galphaz negatively regulates insulin secretion and glucose clearance.
• A global partnership in medical education between Duke University and the National University of Singapore.
• beta-Catenin is a Nek2 substrate involved in centrosome separation.
• Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.
• GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.
• Time-dependent inhibition of isoprenylCysteine carboxyl methyltransferase by indole-based small molecules.
• The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13.
• A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.
• Conversion of protein farnesyltransferase to a geranylgeranyltransferase.
• Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion.
• The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.
• A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.
• Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.
• A role for G(z) in pancreatic islet beta-cell biology.
• Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.
• Selective uncoupling of G alpha 12 from Rho-mediated signaling.
• Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
• Androgen receptor activation by G(s) signaling in prostate cancer cells.
• Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function.
• A small-molecule inhibitor of isoprenylCysteine carboxyl methyltransferase with antitumor activity in cancer cells.
• Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.
• Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion.
• Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family.
• Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 Discrete chemicals as potential fa...
• Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle.
• On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.
• Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
• Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue.
• Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10.
• High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
• Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation.
• Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
• Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells.
• Stereospecificity and kinetic mechanism of human prenylCysteine lyase, an unusual thioether oxidase.
• PrenylCysteine lyase deficiency in mice results in the accumulation of farnesylCysteine and geranylgeranylCysteine in brain and liver.
• Galpha12 and Galpha13 negatively regulate the Adhesive functions of cadherin.
• The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
• Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro.
• Endoscopically assisted fasciotomy: description of technique and in vitro assessment of lower-leg compartment decompression.
• Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
• Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2.
• Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.
• A longitudinal study of recipients'' views and experiences of intra-family egg donation.
• ''Daddy ran out of tadpoles'': how parents tell their children that they are donor conceived, and what their 7-year-olds understand.
• Eye injuries during training exercises with Paint balls.
• Matched study of three methods for palliation of malignant pyloroduodenal obstruction.
• Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis.
• Subsidized housing and children''s nutritional status: data from a multisite surveillance study.
• Validation of an acrosomal stain for equine sperm that differentiates between living and dead sperm.
• Column separation of motile sperm from stallion semen.
• Protein prenylation: molecular mechanisms and functional consequences.
• Characteristics of hospitalizations for patients who use a structured clinical care program for children with medical complexity.
• Compartment Syndromes of the upper extremity.
• Exclusion of the hepatocyte nuclear factor 4alpha as a candidate gene for late-onset NIDDM linked with chromosome 20q.
• Open vs endovascular repair of blunt traumatic thoracic aortic injuries.
• Lipid modifications of G proteins.
• Computer automated morphometric analysis of bull sperm heads.
• The effect of combined arterial hemodynamics on saphenous venous endothelial nitric oxide production.
• Protein lipidation in cell signaling.
• Automated morphometric analysis of stallion spermatozoa.
• Progesterone does not inhibit aggression induced by testosterone metabolites in castrated male mice.
• Can prenylCysteines be exploited as ligands for mammalian multidrug-resistance transporters?
• Replicate and technician variation associated with computer aided bull sperm head morphometry analysis (ASMA).
• Percentage of normal sperm heads is significantly increased by Percoll separation of semen.
• Mechanisms of protein prenylation and role in G protein function.
• Testicular and spermatozoan parameters in the pukeko (Porphyrio porphyrio melanotus).
• Pre-freeze bull sperm head morphometry related to post-thaw fertility.
• Vascular anatomy of the brachioradialis rotational musculocutaneous flap.
• Effects of cryopreservation on bull sperm head morphometry.
• Quantification of normal head morphometry of stallion spermatozoa.
• A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.
• Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions.
• Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB.
• Prenylation and G protein signaling.
• Impaired sperm characteristics in postpubertal growth-hormone-deficient dwarf (dw/dw) rats.
• Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity.
• The effects of cryopreservation on the morphometric dimensions of caprine sperm heads.
• Therapy with growth hormone: major prospects for the treatment of male subfertility?
• GNA13 loss in germinal center B cells leads to impaired apoptosis and GC B cell persistence and promotes lymphoma in vivo.

Schools

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• Dartmouth College

Procedures Preformed

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• ACL (Anterior Cruciate Ligament) Surgery
• All Shoulder or Elbow Replacement Procedures
• Dressing and-or Debridement of Wound, Infection, or Burn (incl. Negative Pressure Wound Therapy)
• Foot and Ankle Fracture Treatment, Closed
• View All

Conditions Treated

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• Achilles Tendinitis
• Acute Deep Vein Thrombosis (DVT)
• Adhesive Capsulitis
• Ankle Fracture
• View All

Doctors Specialties

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• General Surgery
• Orthopedic Surgery
• Vascular Surgery
• Orthopaedic Surgery

Accepted Insurances

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Awards

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• CMS Meaningful Use Stage 1 Certification

Education

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• Emory University
• Geisel School of Medicine at Dartmouth

Drug Facts

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NPI NUMBER		1760416234
NPPES Provider LastName		CASEY
NPPES Provider FirstName		PATRICK
NPPES Provider ZIPCode		033012551
NPPES Provider State		NH
Specialty Description		Orthopedic Surgery
Total Claim Count		119.0
Distinct Opioid Count		2.0
Opioid Claim Count		50.0
Percent Opioid Claims		42.02

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1760416234
Last Name Of The Provider	CASEY
First Name Of The Provider	PATRICK
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