Physician
Ophthalmology
Dr. Paul A. Sieving, MD
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Doctor Paul A. Sieving, MD practices Ophthalmology. He attended University of Illinois College of Medicine at Chicago. University of Illinois College of Medicine at Chicago is ranked 49/85 in Research/PrimaryCare. He received awards:"Elected Member", "Whos Who in Medicine and Healthcare" and "Fellow (FAAO)". Paul A. Sieving is a published doctor as well. He has 81 publications published. The latest was: Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia.
Publications
- Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia.
- Biology and therapy of inherited retinal degenerative disease: insights from mouse models.
- Cone Responses in Usher Syndrome Types 1 and 2 by Microvolt Electroretinography.
- Subjective and Objective Screening Tests for Hydroxychloroquine Toxicity.
- CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function.
- Preclinical Safety Evaluation of a Recombinant AAV8 Vector for X-linked Retinoschisis after Intravitreal Administration in Rabbits.
- Sorting out Co-occurrence of Rare Monogenic Retinopathies: Stargardt Disease Co-existing with Congenital Stationary Night Blindness.
- Phenotypic Conservation in Patients With X-Linked Retinitis Pigmentosa Caused by RPGR Mutations.
- The Golden Era of Ocular Disease Gene Discovery: Race to the Finish.
- Exome Analysis Identified a Novel Mutation in the RBP4 Gene in a Consanguineous Pedigree with Retinal Dystrophy and Developmental Abnormalities.
- Biology of retinoschisin.
- GNAT1 associated with Autosomal Recessive Congenital Stationary Night Blindness.
- CNTF and retina.
- X-linked Retinoschisis: RS1 mutation severity and age affect the ERG phenotype in a cohort of 68 affected male subjects.
- Centrifugal Expansion of Fundus Autofluorescence Patterns in Stargardt Disease Over Time.
- Association of Pathogenic Mutations in TULP1 With Retinitis Pigmentosa in Consanguineous Pakistani Families.
- Mutations in RLBP1 associated with fundus albipunctatus in consanguineous Pakistani families.
- Mutations in the β-subunit of rod phosphodiesterase identified in consanguineous Pakistani families with autosomal recessive retinitis pigmentosa.
- Molecular mechanisms leading to null-protein product from retinoschisin (RS1) signal-sequence mutants in X-linked retinoschisis (XLRS) disease.
- A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness.
- A mutation in ZNF513, a putative regulator of photoreceptor development, causes autosomal-recessive retinitis pigmentosa.
- Retinoschisin (RS1) interacts with negatively charged lipid bilayers in the presence of Ca2+: an atomic force microscopy study.
- Probing potassium channel function in vivo by intracellular delivery of antibodies in a rat model of retinal neurodegeneration.
- A splice-site mutation in a retina-specific exon of BBS8 causes nonsyndromic retinitis pigmentosa.
- A novel locus for autosomal recessive retinitis pigmentosa in a consanguineous Pakistani family maps to chromosome 2p.
- At the frontier of vision research: the National Eye Institute celebrates 40 years.
- Null retinoschisin-protein expression from an RS1 c354del1-ins18 mutation causing progressive and severe XLRS in a cross-sectional family study.
- Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism.
- The effects of transient retinal detachment on cavity size and glial and neural remodeling in a mouse model of X-linked retinoschisis.
- Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function.
- Night blindness and the mechanism of constitutive signaling of mutant G90D rhodopsin.
- Synaptic pathology in retinoschisis knockout (Rs1-/y) mouse retina and modification by rAAV-Rs1 gene delivery.
- Photopic ERG negative response from amacrine cell signaling in RCS rat retinal degeneration.
- Organization and molecular interactions of retinoschisin in photoreceptors.
- Double homozygous waltzer and Ames waltzer mice provide no evidence of retinal degeneration.
- Eyeing a new network.
- Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark.
- Retinoschisin gene therapy and natural history in the Rs1h-KO mouse: long-term rescue from retinal degeneration.
- CNGB3 achromatopsia with progressive loss of residual cone function and impaired rod-mediated function.
- Retinoschisin is a peripheral membrane protein with affinity for anionic phospholipids and affected by divalent cations.
- Genetic ophthalmology and the era of clinical care.
- Molecular testing for hereditary retinal disease as part of clinical care.
- Regulation of rod phototransduction machinery by ciliary neurotrophic factor.
- Identification and characterization of two mature isoforms of retinoschisin in murine retina.
- Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.
- RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.
- Congenital X-linked retinoschisis classification system.
- Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease.
- Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.
- Response to: "Rescuing the NIH before it is too late".
- Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants.
- Retinoschisin expression and localization in rodent and human pineal and consequences of mouse RS1 gene knockout.
- Mutations in the gene encoding the alpha-subunit of rod phosphodiesterase in consanguineous Pakistani families.
- The national eye institute: translational clinical research initiatives on inherited and orphan retinal diseases: personal observations.
- Fostering partnerships: The National Institutes of Health (NIH) Mission.
- Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform.
- Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation.
- Autosomal recessive retinitis pigmentosa is associated with mutations in RP1 in three consanguineous Pakistani families.
- Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice.
- Primate Retinal Signaling Pathways: Suppressing ON-Pathway Activity in Monkey With Glutamate Analogues Mimics Human CSNB1-NYX Genetic Night Blindness.
- Stargardt-like macular dystrophy protein ELOVL4 exerts a dominant negative effect by recruiting wild-type protein into aggresomes.
- A variant form of Oguchi disease mapped to 13q34 associated with partial deletion of GRK1 gene.
- RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis.
- A retinal neuronal developmental wave of retinoschisin expression begins in ganglion cells during layer formation.
- Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology.
- MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells.
- Healthy Vision Month--May 2004: focus is on diabetic retinopathy.
- Atrophic macular degeneration mutations in ELOVL4 result in the intracellular misrouting of the protein.
- Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression.
- Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease.
- Long anterior zonules and pigment dispersion.
- Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.
- Evaluation of the ELOVL4 gene in patients with autosomal recessive retinitis pigmentosa and Leber congenital amaurosis.
- Mutation screening of patients with Leber Congenital Amaurosis or the enhanced S-Cone Syndrome reveals a lack of sequence variations in the NRL gene.
- X-linked recessive atrophic macular degeneration from RPGR mutation.
- Post-photoreceptoral activity dominates primate photopic 32-Hz ERG for sine-, square-, and pulsed stimuli.
- A comprehensive mutation analysis of RP2 and RPGR in a North American cohort of families with X-linked retinitis pigmentosa.
- Retinal cAMP levels during the progression of retinal degeneration in rhodopsin P23H and S334ter transgenic rats.
- Clinical course and visual function in a family with mutations in the RPE65 gene.
- Novel mutations in RPE65 identified in consanguineous Pakistani families with retinal dystrophy.
Schools
University of Illinois At Chicago College of Medicine
Doctors Specialties
- Ophthalmology
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
- Fellow (FAAO)
Education
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Massachusetts Eye & Ear Infirmary -
University of Illinois College of Medicine at Chicago -
University of Illinois College of Medicine
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