Associate Professor, Neurology, University of Pittsburgh School of Medicine
Neurology
Dr. Paula R. Clemens, MD
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Paula Clemens works in the field of Neurology. He received 1 awards: "CMS Meaningful Use Stage 1 Certification". Paula Clemens has written publications. He has 75 publications published with PubMed. The lastest paper is: 'Evaluation of the insertion/deletion ACE gene polymorphism as a risk factor for carotid artery intima-media thickening and hypertension in young type 1 diabetic patients.' He accepts all Medicare patients.
Publications
- Parental attitudes toward newborn screening for Duchenne/Becker Muscular dystrophy and spinal Muscular atrophy.
- CINRG Duchenne Natural History Study demonstrates insufficient diagnosis and treatment of cardiomyopathy in Duchenne Muscular dystrophy.
- Functional Redundancy of MyD88-Dependent Signaling Pathways in a Murine Model of Histidyl-Transfer RNA Synthetase-Induced Myositis.
- The cooperative international neuroMuscular research group duchenne natural history study-a longitudinal investigation in the era of glucocorticoid therapy: Design of ...
- The cooperative international neuroMuscular research group Duchenne natural history study: Glucocorticoid treatment preserves clinically meaningful functional mileston...
- AAV8 delivery of recombinant A20 to skeletal muscle reduces pathological activation of NF-κB in muscle of mdx mice.
- Pharmacological therapies for Muscular dystrophies.
- Effect of NF-?B inhibition on AAV9 minidystrophin gene transfer to the mdx mouse.
- Deubiquitinating enzyme A20 negatively regulates NF-{kappa}B signaling in skeletal muscle in mdx mice.
- Systemic delivery of NEMO binding domain/IKKgamma inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology.
- Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.
- Current Status of Pharmaceutical and Genetic Therapeutic Approaches to Treat DMD.
- Liquid formulation of pentoxifylline is a poorly tolerated treatment for duchenne Dystrophy.
- Role of innate immunity in a murine model of histidyl-transfer RNA synthetase (Jo-1)-mediated myositis.
- Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne Muscular dystrophy.
- Role of innate immunity in a model of histidyl-tRNA synthetase (Jo-1)-mediated myositis.
- A randomized study of alglucosidase alfa in late-onset Pompe's Disease.
- Gene therapy for Muscular dystrophy reaches human clinical trial.
- Cellular caspase-8-like inhibitory protein (cFLIP) prevents inhibition of muscle cell differentiation induced by Cancer cells.
- Patterns of gene expression from in utero delivery of adenoviral-associated vector serotype 1.
- Sustained muscle expression of dystrophin from a high-capacity adenoviral vector with Systemic gene transfer of T cell costimulatory blockade.
- Biocompatibility of adenoviral vectors in poly(vinyl chloride) tubing catheters with presence or absence of plasticizer di-2-ethylhexyl phthalate.
- Binding of adenoviral fiber knob to the coxsackievirus-adenovirus receptor is crucial for transduction of fetal muscle.
- Immune response to full-length dystrophin delivered to Dmd muscle by a high-capacity adenoviral vector.
- Systemic delivery of a high-capacity adenoviral vector expressing mouse CTLA4Ig improves skeletal muscle gene therapy.
- Chronic eosinophilic perimyositis with persistent myalgias.
- In utero delivery of oligodeoxynucleotides for gene correction.
- [Age dependency of normal and modified nucleobases in urine in correlation to growth velocity (author''s transl)].
- Family study in familial hypercholesterolemia with a receptor-negative homozygous 9-year-old boy.
- Evaluation of the insertion/deletion ACE gene polymorphism as a risk factor for carotid artery intima-media thickening and hypertension in young type 1 Diabetic patients.
- Two hot spots of recombination in the DMD gene correlate with the deletion prone regions.
- Protein transduction: identification, characterization and optimization.
- Progress toward human gene therapy.
- Species-specific immune responses generated by histidyl-tRNA synthetase immunization are associated with muscle and lung inflammation.
- Randomized, blinded trial of weekend vs daily prednisone in Duchenne Muscular dystrophy.
- Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.
- Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice.
- Improvement of the mdx mouse dystrophic phenotype by Systemic in utero AAV8 delivery of a minidystrophin gene.
- Full-length dystrophin gene transfer to the mdx mouse in utero.
- Systemic delivery of AAV8 in utero results in gene expression in diaphragm and limb muscle: treatment implications for muscle disorders.
- Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles.
- Viral gene delivery to skeletal muscle: insights on maturation-dependent loss of fiber infectivity for adenovirus and herpes simplex type 1 viral vectors.
- Persistence in muscle of an adenoviral vector that lacks all viral genes.
- HyperCKemic, proximal muscular dystrophies and the dystrophin membrane cytoskeleton, including dystrophinopathies, sarcoglycanopathies, and merosinopathies.
- In vivo muscle gene transfer of full-length dystrophin with an adenoviral vector that lacks all viral genes.
- A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase.
- Cognitive dysfunction as the major presenting feature of Becker's Muscular dystrophy.
- Recombinant truncated dystrophin minigenes: construction, expression, and adenoviral delivery.
- Gene transfer therapy for heritable Disease: cell and expression targeting.
- Gene therapy prospects for Duchenne Muscular dystrophy.
- Linkage disequilibria among (CA)n polymorphisms in the human dystrophin gene and their implications in carrier detection and prenatal diagnosis in Duchenne and Becker ...
- Human muscle glycogenosis due to phosphorylase kinase deficiency associated with a nonsense mutation in the muscle isoform of the alpha subunit.
- Adult phosphorylase b kinase deficiency.
- Carrier detection and prenatal diagnosis in Duchenne and Becker Muscular dystrophy families, using dinucleotide repeat polymorphisms.
- Pentanucleotide repeat length polymorphism at the human CD4 locus.
- Mitochondrial DNA deletions in mitochondrial cytopathies: observations in 19 patients.
- Premature chain termination mutation causing Duchenne Muscular dystrophy.
- Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection.
- Transfer of full-length Dmd to the diaphragm muscle of Dmd(mdx/mdx) mice through Systemic administration of plasmid DNA.
- Local high-capacity adenovirus-mediated mCTLA4Ig and mCD40Ig expression prolongs recombinant gene expression in skeletal muscle.
- Clinical evaluator reliability for quantitative and manual muscle testing measures of strength in children.
- Polylysine modification of adenoviral fiber protein enhances muscle cell transduction.
- DNA from both high-capacity and first-generation adenoviral vectors remains intact in skeletal muscle.
- Progress in gene therapy for Duchenne Muscular dystrophy.
- CTLA4Ig delivered by high-capacity adenoviral vector induces stable expression of dystrophin in mdx mouse muscle.
- Comparison of high-capacity and first-generation adenoviral vector gene delivery to murine muscle in utero.
- Fetal muscle gene transfer is not enhanced by an RGD capsid modification to high-capacity adenoviral vectors.
- Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases.
- The companions: regulatory T cells and gene therapy.
- CINRG randomized controlled trial of creatine and glutamine in Duchenne Muscular dystrophy.
- Diagnosis and management of Duchenne Muscular dystrophy, part 2: implementation of multidisciplinary care.
- Diagnosis and management of Duchenne Muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management.
- Migration of dendritic cells from murine skeletal muscle.
- Novel mutation in MYH7 gene associated with distal myopathy and cardiomyopathy.
Schools
Medical College of Pennsylvania
Baylor College Of Med
Dartmouth Hitchcock M C
Mayo Grad School MedMayo Fndn
Procedures Preformed
- EEG (Electroencephalogram)
Conditions Treated
- Ataxia
- Bell's Palsy
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Aneurysm
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Doctors Specialties
- Aerospace Medicine
- Neurology
- Occupational Medicine
- Preventive Aerospace Medicine
- Preventive Occupational Medicine
Accepted Insurances
- Aetna HMO
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- CoreSource
- Community Blue PPO
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Mutual of Omaha
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
- UPMC PPO
- UPMC Health Plan
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Mayo School of Graduate Medical Education -
Dartmouth-Hitchcock Medical Center
Hospital
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UPMC Presbyterian Shadyside
Drug Facts
| NPI NUMBER | 1447222096 | |
| NPPES Provider LastName | CLEMENS | |
| NPPES Provider FirstName | PAULA | |
| NPPES Provider ZIPCode | 152133215 | |
| NPPES Provider State | PA | |
| Specialty Description | Neurology | |
| Total Claim Count | 105.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1447222096 |
| Last Name Of The Provider | CLEMENS |
| First Name Of The Provider | PAULA |
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