Professor, Internal Medicine, University of Iowa College of Medicine
Cardiology
Dr. Peter D. Snyder, MD
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Peter Snyder works in the field of Cardiology. He researched medicine at University of Iowa Carver College of Medicine. University of Iowa Carver College of Medicine is ranked 29/16 in Research/PrimaryCare. He received 1 awards: "Elected Member". Peter Snyder is a published physician as well. He has 36 publications published. The latest was: Acetylation Stimulates the Epithelial Sodium Channel by Reducing Its Ubiquitination and Degradation.
Publications
- Acetylation Stimulates the Epithelial Sodium Channel by Reducing Its Ubiquitination and Degradation.
- Intersubunit conformational changes mediate epithelial sodium channel gating.
- Ubiquitin Specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel.
- Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II.
- Intoxicated Na+ channels. Focus on "Ethanol stimulates epithelial sodium channels by elevating reactive oxygen species".
- Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent upon their subunit composition.
- Identification of Extracellular Domain Residues Required for Epithelial Na+ Channel Activation by Acidic pH.
- Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9).
- Identification of epithelial Na+ channel (ENaC) intersubunit Cl- inhibitory residues suggests a trimeric alpha gamma beta channel architecture.
- Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.
- The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function.
- Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.
- Extracellular chloride regulates the epithelial sodium channel.
- Mutations of KCNJ10 together with mutations of SLC26A4 cause digenic nonsyndromic hearing loss associated with enlarged vestibular aqueduct syndrome.
- Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits.
- Extracellular protons regulate human ENaC by modulating Na+ self-inhibition.
- Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.
- An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function.
- Intracellular sodium regulates proteolytic activation of the epithelial sodium channel.
- Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.
- Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.
- Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channels.
- Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC.
- Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.
- Minireview: regulation of epithelial Na+ channel trafficking.
- Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.
- The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport.
- cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2.
- Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference.
- Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.
- A region directly following the second transmembrane domain in gamma ENaC is required for normal channel gating.
- Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.
- The epithelial Na+ channel: cell surface insertion and retrieval in Na+ homeostasis and hypertension.
- Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons.
- Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.
Schools
Thomas Jefferson University
Naval Med Center San Diego
Doctors Specialties
- Diagnostic Radiology
- Cardiology
Accepted Insurances
Awards
- Elected Member
Education
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University of Iowa Hospitals and Clinics -
University of Iowa Carver College of Medicine
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