Physician
Hematology
Dr. Peter F. Bross, MD
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Peter Bross practices Hematology. He graduated from University of Virginia School of Medicine. Dr. Peter F. Bross is also a published doctor. He has 100 publication published. The most recent publication is: Clear correlation of genotype with disease phenotype in very-long-chain acyl-CoA dehydrogenase deficiency.
Publications
- Approval summary for bortezomib for injection in the treatment of multiple myeloma.
- Fulvestrant in postmenopausal women with advanced breast cancer.
- Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy.
- FDA drug approval summaries: fulvestrant.
- The role of chaperone-assisted folding and quality control in inborn errors of metabolism: protein folding disorders.
- Medium-chain acyl-CoA dehydrogenase (MCAD) mutations identified by MS/MS-based prospective screening of newborns differ from those observed in patients with clinical s...
- Prevalent mutations in fatty acid oxidation disorders: diagnostic considerations.
- Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular...
- Human and mouse mitochondrial orthologs of bacterial ClpX.
- The C-terminal N-glycosylation sites of the human alpha1,3/4-fucosyltransferase III, -V, and -VI (hFucTIII, -V, adn -VI) are necessary for the expression of full enzym...
- Defective folding and rapid degradation of mutant proteins is a common disease mechanism in genetic disorders.
- Mutations of human medium-chian acyl-CoA dehydrogenase.
- Grp78 is involved in retention of mutant low density lipoprotein receptor protein in the endoplasmic reticulum.
- Characterization of mouse Clpp protease cDNA, gene, and protein.
- Biochemical characterisation of mutations of human medium-chain acyl-CoA dehydrogenase.
- Empiric antimicrobial therapy of febrile neutropenic patients undergoing haematopoietic stem cell transplantation.
- Protein misfolding and degradation in genetic diseases.
- Expression of transforming growth factor alpha and epidermal growth factor receptor in human bladder cancer.
- A polymorphic variant in the human electron transfer flavoprotein alpha-chain (alpha-T171) displays decreased thermal stability and is overrepresented in very-long-cha...
- Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy.
- Clear correlation of genotype with disease phenotype in very-long-chain acyl-CoA dehydrogenase deficiency.
- Biochemical characterization of a variant human medium-chain acyl-CoA dehydrogenase with a disease-associated mutation localized in the active site.
- Quantitative analysis of the human epidermal growth factor receptor messenger RNA using reverse transcription-PCR: a methodological study of imprecision.
- Rapid degradation of short-chain acyl-CoA dehydrogenase variants with temperature-sensitive folding defects occurs after import into mitochondria.
- A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization.
- Identification of four new mutations in the short-chain acyl-CoA dehydrogenase (SCAD) gene in two patients: one of the variant alleles, 511C-->T, is present at an unex...
- Structural organization of the human short-chain acyl-CoA dehydrogenase gene.
- Impaired folding and subunit assembly as disease mechanism: the example of medium-chain acyl-CoA dehydrogenase deficiency.
- Biochemical characterization of purified, human recombinant Lys304-->Glu medium-chain acyl-CoA dehydrogenase containing the common disease-causing mutation and compari...
- The molecular basis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in compound heterozygous patients: is there correlation between genotype and phenotype?
- Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels.
- Cloning and characterization of human very-long-chain acyl-CoA dehydrogenase cDNA, chromosomal assignment of the gene and identification in four patients of nine diffe...
- Medium-long-chain chimeric human Acyl-CoA dehydrogenase: medium-chain enzyme with the active center base arrangement of long-chain Acyl-CoA dehydrogenase.
- The mutational spectrum in very long-chain acyl-CoA dehydrogenase deficiency.
- Ethylmalonic aciduria is associated with an amino acid variant of short chain acyl-coenzyme A dehydrogenase.
- Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene.
- Comparison between medium-chain acyl-CoA dehydrogenase mutant proteins overexpressed in bacterial and mammalian cells.
- A silent A to G mutation in exon 11 of the medium-chain acyl-CoA dehydrogenase (MCAD) gene.
- Disease-causing mutations in exon 11 of the medium-chain acyl-CoA dehydrogenase gene.
- Co-overexpression of bacterial GroESL chaperonins partly overcomes non-productive folding and tetramer assembly of E. coli-expressed human medium-chain acyl-CoA dehydr...
- A rare disease-associated mutation in the medium-chain acyl-CoA dehydrogenase (MCAD) gene changes a conserved arginine, previously shown to be functionally essential i...
- Characterization of wild-type human medium-chain acyl-CoA dehydrogenase (MCAD) and mutant enzymes present in MCAD-deficient patients by two-dimensional gel electrophor...
- Amino acid polymorphism (Gly209Ser) in the ACADS gene.
- Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency due to heterozygosity for the common mutation and an allele resulting in low levels of MCAD mRNA.
- Prenatal diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in a family with a previous fatal case of sudden unexpected death in childhood.
- Effects of two mutations detected in medium chain acyl-CoA dehydrogenase (MCAD)-deficient patients on folding, oligomer assembly, and stability of MCAD enzyme.
- Molecular diagnosis and characterization of medium-chain acyl-CoA dehydrogenase deficiency.
- Functional analysis of the adsorption protein of two filamentous phages with different host specificities.
- Dissection of functional domains in phage fd adsorption protein. Discrimination between attachment and penetration sites.
- Release of periplasmic proteins induced in E. coli by expression of an N-terminal proximal segment of the phage fd gene 3 protein.
- Characterization of wild-type and an active site mutant of human medium chain acyl-CoA dehydrogenase after expression in Escherichia coli.
- Molecular characterization of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: identification of a lys329 to glu mutation in the MCAD gene, and expression of ina...
- Characterization of a disease-causing Lys329 to Glu mutation in 16 patients with medium-chain acyl-CoA dehydrogenase deficiency.
- The adsorption protein of phage IKe. Localization by deletion mutagenesis of domains involved in infectivity.
- Genetic heterogeneity in MCAD deficiency: frequency of K329E allele and identification of three additional mutant alleles.
- Characterization of medium-chain acyl-CoA dehydrogenase (MCAD) with a point mutation associated with MCAD deficiency.
- Molecular analysis of medium-chain acyl-CoA dehydrogenase deficiency: a diagnostic approach.
- Alpha, beta-dehydrogenation by acyl-CoA dehydrogenases: role of functional groups at the active center.
- Expression of wild-type and mutant medium-chain acyl-CoA dehydrogenase (MCAD) cDNA in eucaryotic cells.
- Quantitative proteomics reveals cellular targets of celastrol.
- Cofactors and metabolites as potential stabilizers of mitochondrial acyl-CoA dehydrogenases.
- A cell model to study different degrees of Hsp60 deficiency in HEK293 cells.
- A polymorphic position in electron transfer flavoprotein modulates kinetic stability as evidenced by thermal stress.
- Emerging roles for riboflavin in functional rescue of mitochondrial β-oxidation flavoenzymes.
- A cellular viability assay to monitor drug toxicity.
- Measuring consequences of protein misfolding and cellular stress using OMICS techniques.
- Protein misfolding and cellular stress: an overview.
- Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency.
- NMR-based metabonomic investigation of heat stress in myotubes reveals a time-dependent change in the metabolites.
- Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice.
- Anti-inflammatory heat shock protein 70 genes are positively associated with human survival.
- Misfolding of short-chain acyl-CoA dehydrogenase leads to mitochondrial fission and oxidative stress.
- Oxidative stress-induced metabolic changes in mouse C2C12 myotubes studied with high-resolution 13C, 1H, and 31P NMR spectroscopy.
- Metabolic profiling of heat or anoxic stress in mouse C2C12 myotubes using multinuclear magnetic resonance spectroscopy.
- Mitochondrial proteomics on human fibroblasts for identification of metabolic imbalance and cellular stress.
- Sequence variants in SPAST, SPG3A and HSPD1 in hereditary spastic paraplegia.
- Drug-diagnostic codevelopment strategies: FDA and industry dialog at the 4th FDA/DIA/PhRMA/PWG/BIO Pharmacogenomics Workshop.
- Role of flavinylation in a mild variant of multiple acyl-CoA dehydrogenation deficiency: a molecular rationale for the effects of riboflavin supplementation.
- Mitochondrial fatty acid oxidation defects--remaining challenges.
- Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy.
- The ACADS gene variation spectrum in 114 patients with short-chain acyl-CoA dehydrogenase (SCAD) deficiency is dominated by missense variations leading to protein misf...
- The Hsp60-(p.V98I) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.
- Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13).
- A novel mutation in the HSPD1 gene in a patient with hereditary spastic paraplegia.
- Single-nucleotide variations in the genes encoding the mitochondrial Hsp60/Hsp10 chaperone system and their disease-causing potential.
- Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes.
- Heat-shock protein 70 genes and human longevity: a view from Denmark.
- Protein misfolding and human disease.
- Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chr...
- Protein misfolding, aggregation, and degradation in disease.
- Differential degradation of variant medium-chain acyl-CoA dehydrogenase by the protein quality control proteases Lon and ClpXP.
- Down-regulation of Hsp60 expression by RNAi impairs folding of medium-chain acyl-CoA dehydrogenase wild-type and disease-associated proteins.
- Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation.
- The Y42H mutation in medium-chain acyl-CoA dehydrogenase, which is prevalent in babies identified by MS/MS-based newborn screening, is temperature sensitive.
- Misfolding, degradation, and aggregation of variant proteins. The molecular pathogenesis of short chain acyl-CoA dehydrogenase (SCAD) deficiency.
- Protein quality control in the endoplasmic reticulum.
- Investigation of folding and degradation of in vitro synthesized mutant proteins in mitochondria.
- Basic introduction to in vivo protein folding and its defects.
- Clear relationship between ETF/ETFDH genotype and phenotype in patients with multiple acyl-CoA dehydrogenation deficiency.
Schools
University of Virginia Main Campus
Kaiser Found Hospital
Reading Hospital Med Center
The George Washington University
Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
Education
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George Washington University -
Kaiser Permanente Medical Center -
University of Virginia School of Medicine
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