Professor, Allergy and Immunology, Yale University School of Medicine
Allergy & Immunology
Dr. Philip W. Askenase, MD
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Philip Askenase is an expert in the field of Allergy & Immunology. He researched medicine at Yale University School of Medicine. Yale University School of Medicine is one of the top medical schools in the US. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. He has 3 awards "Fellow (FACP)", "Elected Member" and "Whos Who in Medicine and Healthcare". Philip Askenase is also published. He has 101 publications published. The lastest publication: "Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity.'
Publications
- Diagnostic and therapeutic potentials of exosomes in CNS diseases.
- Stimulatory lipids accumulate in the mouse liver within 30 minutes of contact sensitization to facilitate activation of naïve iNKT cells in a CD1d-depende...
- Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.
- Epicutaneous immunization with protein antigen in the presence of TLR4 ligand induces TCR alpha beta+CD4+ T contrasuppressor cells that reverse skin-induced suppressio...
- Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity.
- c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.
- Invariant NKT cells rapidly activated via immunization with diverse contact antigens collaborate in vitro with B-1 cells to initiate contact sensitivity.
- Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.
- An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of...
- TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo.
- Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity.
- B-1 B cells mediate required early T cell recruitment to elicit protein-induced delayed-type hypersensitivity.
- Mast cells and the mediation of T-cell recruitment in arthritis.
- B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity.
- Subunits of IgM reconstitute defective contact sensitivity in B-1 cell-deficient xid mice: kappa light chains recruit T cells independent of complement.
- Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation.
- CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation.
- Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells.
- Interleukin-4-dependent innate collaboration between iNKT cells and B-1 B cells controls adaptative contact sensitivity.
- Alpha-galactosylceramide-induced iNKT cells suppress experimental Allergic asthma in sensitized mice: role of IFN-gamma.
- Epicutaneous immunization induces alphabeta T-cell receptor CD4 CD8 double-positive non-specific suppressor T cells that inhibit contact sensitivity via transforming g...
- Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.
- Extravascular T-cell recruitment requires initiation begun by Valpha14+ NKT cells and B-1 B cells.
- Early delayed-type hypersensitivity eosinophil infiltrates depend on T helper 2 cytokines and interferon-gamma via CXCR3 chemokines.
- Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model.
- Topical tacrolimus and cyclosporin A differentially inhibit early and late effector phases of cutaneous delayed-type and immunoglobulin E hypersensitivity.
- Yes T cells, but three different T cells (alphabeta, gammadelta and NK T cells), and also B-1 cells mediate contact sensitivity.
- T cytotoxic 1 and T cytotoxic 2 CD8 T cells both inhibit IgE responses.
- B-1 B cell IgM antibody initiates T cell elicitation of contact sensitivity.
- Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma.
- Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling.
- Atypical fatal hypocomplementemic urticarial vasculitis with involvement of native and homograft aortic valves in an African American man.
- IL-12 reverses established tolerance mediated by TCRalphabeta+ but not by TCRgammadelta+ suppressor T cells.
- Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment.
- Gee whiz: CpG DNA allergy therapy!
- Soluble T cell receptors modulate cytokine production and oxygen metabolism by peritoneal macrophages.
- IL-12 is produced by antigen-presenting cells stimulated with soluble alphabeta TCR and restores impaired T(h)1 responses.
- Endothelial cell E- and P-selectin up-regulation in murine contact sensitivity is prolonged by distinct mechanisms occurring in sequence.
- C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocy...
- Role of interleukin-4 in down-regulation of contact sensitivity by gammadelta T cells from tolerized T-cell receptor alpha-/- mice.
- A new paradigm of T cell allergy: requirement for the B-1 cell subset.
- Human allogeneic vascular rejection after arterial transplantation and peripheral lymphoid reconstitution in severe combined immunodeficient mice.
- Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity.
- Cross-talk between gammadelta T lymphocytes and immune cells in humoral response.
- Allogeneic and xenogeneic vascular injury and protection.
- Dermal microvascular injury in the human peripheral blood lymphocyte reconstituted-severe combined immunodeficient (HuPBL-SCID) mouse/skin allograft model is T cell me...
- Positive regulatory gamma delta T cells in contact sensitivity: augmented responses by in vivo treatment with anti-gamma delta monoclonal antibody, or anti-V gamma 5 o...
- IL-12 reverses established antigen-specific tolerance of contact sensitivity by affecting costimulatory molecules B7-1 (CD80) and B7-2 (CD86).
- Aggregated immunoglobulin protects immune T cells from suppression: dependence on isotype, Fc portion, and macrophage FcgammaR.
- Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon gamma: a possible in...
- Recombinant soluble alphabeta T cell receptors protect T cells from immune suppression: requirement for aggregated multimeric, disulfide-linked alphabeta heterodimers.
- Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras.
- Nonatopic asthma: in vivo airway hyperreactivity adoptively transferred to naive mice by THY-1(+) and B220(+) antigen-specific cells that lack surface expression of CD3.
- Pig but not human interferon-gamma initiates human cell-mediated rejection of pig tissue in vivo.
- Gamma/delta T cells from tolerized alpha/beta-TCR-deficient mice antigen specifically inhibit contact sensitivity in vivo and IFN-gamma production in vitro.
- Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice.
- Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies.
- Gamma delta T cells from tolerized alpha beta T cell receptor (TCR)-deficient mice inhibit contact sensitivity-effector T cells in vivo, and their interferon-gamma pro...
- Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity.
- The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: a pilot study.
- Possible involvement of C5/C5a in the efferent and elicitation phases of contact sensitivity.
- Immune or normal gamma delta T cells that assist alpha beta T cells in elicitation of contact sensitivity preferentially use V gamma 5 and V delta 4 variable region ge...
- Inhibition of IL-2-dependent proliferation by a prostaglandin-dependent suppressor factor.
- Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse.
- Antigen receptors on Thy-1+ CD3- CS-initiating cell. In vitro desensitization with hapten-amino acid or hapten-Ficoll conjugates, versus hapten-protein conjugates, sug...
- Adoptive cell transfer of contact sensitivity-initiation mediated by nonimmune cells sensitized with monoclonal IgE antibodies. Dependence on host skin mast cells.
- Gamma delta T cells in normal spleen assist immunized alpha beta T cells in the adoptive cell transfer of contact sensitivity. Effect of Bordetella pertussis, cyclopho...
- Elicitation of nickel sulfate (NiSO4)-specific delayed-type hypersensitivity requires early-occurring and early-acting, NiSO4-specific DTH-initiating cells with an unu...
- Regulation of Allergic contact sensitivity in mice: soluble alpha beta T cell receptors, derived via cDNA transfection and enzymatic cleavage from the surface of T cel...
- Role of mast cells versus basophils in IgE-dependent local ear skin release of the serotonin required to initiate contact sensitivity in mice.
- gamma delta T cells in normal murine spleen assist immunized alpha beta T cells in the adoptive cell transfer of contact sensitivity: effect of Bordetella pertussis. C...
- A role for platelet release of serotonin in the initiation of contact sensitivity.
- Soluble T cell receptors: detection and quantitative assay in fluid phase via ELISA or immuno-PCR.
- Monoclonal, antigen-specific, T cell contrasuppressor factor expresses determinants of TCR alpha-chain (not necessarily TCR beta-chain), having a molecular mass of abo...
- DNFB contact sensitivity (CS) in BALB/c and C3H/He mice: requirement for early-occurring, early-acting, antigen-specific, CS-initiating cells with an unusual phenotype...
- Chronic ear infection in the immunodeficient patient.
- H-2-dependent cell-mediated immunity in vivo: delayed-type hypersensitivity and contact sensitization induced by fluorescein isothiocyanate-conjugated cells.
- Role of antigen-presenting cells in the development and persistence of contact hypersensitivity.
- Cutaneous basophil responses and immune resistance of guinea pigs to ticks: passive transfer with peritoneal exudate cells or serum.
- Immune serum transfer of cutaneous basophil-associated resistance to ticks: mediation by 7SIgG1 antibodies.
- Serotonin storage pools in basophil leukemia and mast cells: characterization of two types of serotonin binding protein and radioautographic analysis of the intracellu...
- Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) i...
- Prolonged reduction in basophil counts at cutaneous basophil hypersensitivity reaction sites challenged with antigen.
- Ixodes dammini: induced skin lesions in guinea pigs and rabbits compared to erythema chronicum migrans in patients with lyme arthritis.
- Blood eosinophil and basophil responses in guinea pigs parasitized by Amblyomma americanum ticks.
- Cutaneous basophil-associated resistance to ectoparasites (ticks). I. Transfer with immune serum or immune cells.
- Transfer of an antigen-specific immediate hypersensitivity-like reaction with an antigen-binding factor produced by T cells.
- T cell-dependent mast cell degranulation and release of serotonin in murine delayed-type hypersensitivity.
- Skin testing and erythrocyte sedimentation rate in women undergoing breast biopsy.
- Cutaneous basophil-associated resistance to ectoparasites (ticks). IV. Differences in blood basophil kinetics in hosts parasitized by ixodid and argasid ticks.
- The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice.
- Histopathology of delayed-onset hypersensitivities in contact-sensitive guinea pigs.
- Cutaneous basophil associated resistance to ectoparasites (ticks). Electron microscopy of Rhipicephalus appendiculatus larval feeding sites in actively sensitised guin...
- Rhipicephalus appendiculatus: larval feeding sites in guinea pigs actively sensitized and receiving immune serum.
- IgE antibody production in guinea pigs treated with cyclophosphamide.
- Ixodes holocyclus: kinetics of cutaneous basophil responses in naive, and actively and passively sensitized guinea pigs.
- IgE antibody-mediated cutaneous basophil hypersensitivity reactions in guinea pigs.
- Ornithodorus tartakovskyi: quantitation and ultrastructure of cutaneous basophil responses in the guinea pig.
- Mast cell activation and vascular alterations in immediate hypersensitivity-like reactions induced by a T cell-derived antigen-binding factor.
- Defective elicitation of delayed-type hypersensitivity in W/Wv and SI/SId mast cell-deficient mice.
Schools
Yale University
Boston City Hospital Harvard
Conditions Treated
- Allergic Rhinitis
- Angioedema
- Hives
Doctors Specialties
- Internal Medicine
- Allergy
- Immunology
Accepted Insurances
Awards
- Fellow (FACP)
- Elected Member
- Whos Who in Medicine and Healthcare
Education
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Boston University Medical Center -
Yale University School of Medicine
Hospital
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Yale-New Haven Hospital
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