Physician
Cardiology
Dr. Rakesh K. Jain, MD
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Rakesh K. Jain is an expert in the field of Cardiology. He studied medicine at University at Buffalo, School of Medicine and Biomedical Sciences. He received 3 awards: "CMS Meaningful Use Stage 1 Certification", "Elected Member" and "Fellow (FACC)". Doctor Rakesh K. Jain, MD has written publications. He has 99 publications published with PubMed. The lastest publication is: 'PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity.'
Publications
- Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment.
- PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity.
- Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability.
- Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model.
- Design considerations for nanotherapeutics in oncology.
- Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.
- Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.
- Emerging strategies for treating brain metastases from breast cancer.
- Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery.
- Quantum dot/antibody conjugates for in vivo cytometric imaging in mice.
- Lessons From Anti-Vascular Endothelial Growth Factor and Anti-Vascular Endothelial Growth Factor Receptor Trials in Patients With Glioblastoma.
- Using tumour phylogenetics to identify the roots of metastasis in humans.
- CXCR4 inhibition in tumor microenvironment facilitates anti-PD-1 immunotherapy in sorafenib-treated HCC in mice.
- Vessel calibre-a potential MRI biomarker of tumour response in clinical trials.
- The role of mechanical forces in tumor growth and therapy.
- Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure.
- Hypermutable DNA chronicles the evolution of human colon cancer.
- A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreat...
- Benefits of vascular normalization are dose and time dependent--letter.
- mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1.
- Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
- Strategies for advancing cancer nanomedicine.
- A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2 in Patients with Advanced Hepatocellular Cancer.
- Sulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity.
- Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
- Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.
- Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
- Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Gli...
- Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
- Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
- Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse.
- Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
- Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers.
- Can We Identify Predictive Biomarkers for Antiangiogenic Therapy of Cancer Using Mathematical Modeling?
- Efficacy, Safety, Pharmacokinetics, and Biomarkers of Cediranib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study.
- Vascular normalization as an emerging strategy to enhance cancer immunotherapy.
- Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.
- Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
- Spatial charge configuration regulates nanoparticle transport and binding behavior in?vivo.
- Mechanical compression drives cancer cells toward invasive phenotype.
- Increased Survival of Glioblastoma Patients who Respond to Anti-angiogenic Therapy with Elevated Blood Perfusion.
- Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites.
- Impaired lymphatic contraction associated with immunosuppression.
- Pathway for Degradation of 2-Chloro-4-Nitrophenol in Arthrobacter sp. SJCon.
- Biotransformation of 4-chloro-2-nitrophenol into 5-chloro-2-methylbenzoxazole by a marine Bacillus sp. strain MW-1.
- Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.
- BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
- Dehydro-{alpha}-lapachone, a plant product with antivascular activity.
- Normalization of the vasculature for treatment of cancer and other diseases.
- Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
- PDGF-D Improves Drug Delivery and Efficacy via Vascular Normalization, But Promotes Lymphatic Metastasis by Activating CXCR4 in Breast Cancer.
- Reductive dehalogenation mediated initiation of aerobic degradation of 2-chloro-4-nitrophenol (2C4NP) by Burkholderia sp. strain SJ98.
- Cancer cell associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
- Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines.
- T(1)- and T(2)(*)-dominant extravasation correction in DSC-MRI: Part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients.
- Serial MR Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma.
- CXCL12 (SDF1{alpha})-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?
- The biology of brain metastases-translation to new therapies.
- TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.
- Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
- Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
- Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value.
- Multistage nanoparticle delivery system for deep penetration into tumor tissue.
- Scaling rules for diffusive drug delivery in tumor and normal tissues.
- Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
- C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
- Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.
- Spontaneous Nonthymic Tumors in SCID Mice.
- Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape.
- Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
- Lessons from the adjuvant bevacizumab trial on colon cancer: what next?
- Malignant cells facilitate lung metastasis by bringing their own soil.
- Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
- Phase II Study of Neoadjuvant Bevacizumab and Radiotherapy for Resectable Soft Tissue Sarcomas.
- Lymphotoxin-alpha contributes to lymphangiogenesis.
- Description of Chryseomicrobium imtechense gen. nov., sp. nov., a new member of the family Planococcaceae.
- Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
- Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard...
- Notch leads lymphatics and links them to blood vessels.
- Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
- In vivo imaging of tumors.
- A case study for assessment of microbial community dynamics in genetically modified Bt cotton crop fields.
- Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
- Premetastatic lung "niche": is vascular endothelial growth factor receptor 1 activation required?
- Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.
- Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
- Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.
- Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib.
- p-Nitrophenol degradation via 4-nitrocatechol in Burkholderia sp. SJ98 and cloning of some of the lower pathway genes.
- Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
- In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.
- In vivo wide-area cellular imaging by side-view endomicroscopy.
- WITHDRAWN: Nemaline myopathy presenting as a stiff baby.
- Degradation of 4-nitrophenol, 2-chloro-4-nitrophenol, and 2,4-dinitrophenol by Rhodococcus imtechensis strain RKJ300.
- p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
- Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
- InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
- Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers?
Schools
U Of Buffalo SUNY Sch Of Med amp Biomedical Sci
Washington Dc Va Medical Center
Georgetown University Hospital
Virginia Commonwealth University Medical Center
SUNY At Buffalo
Procedures Preformed
- Angioplasty With Stent Placement
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Event Monitor
- Cardioversion
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Doctors Specialties
- Cardiology
- Interventional Cardiology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Fellow (FACC)
Education
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Virginia Commonwealth University Health System -
Georgetown University Hospital -
University at Buffalo, School of Medicine and Biomedical Sciences
Drug Facts
| NPI NUMBER | 1013992874 | |
| NPPES Provider LastName | JAIN | |
| NPPES Provider FirstName | RAKESH | |
| NPPES Provider ZIPCode | 23225 | |
| NPPES Provider State | VA | |
| Specialty Description | Cardiology | |
| Total Claim Count | 4452.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1013992874 |
| Last Name Of The Provider | JAIN |
| First Name Of The Provider | RAKESH |
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