Associate Professor, Medicine, Massachusetts General Hospital, Harvard Medical School
Gastroenterology
Dr. Ramnik J. Xavier, MD
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Ramnik Xavier practices Gastroenterology. He attended University of Zimbabwe Huggins School of Medicine. He received awards:"Fellow (AGAF)" and "Super Doctor". Doctor Ramnik J. Xavier, MD is also published. He has 101 publications published. The lastest publication: "O-015YIAlterations in the FOXP3-EZH2 Pathway Associates with Increased Susceptibility to Colitis in Both Mice and Human.' He is registered with Medicare.
Publications
- O-002 Genes in IBD-Associated Risk Loci Demonstrate Genotype-, Tissue-, and Inflammation-Specific Patterns of Expression in Terminal Ileum and Colon Mucosal Tissue.
- Genetic basis of TNF-α antagonist associated psoriasis in inflammatory bowel Diseases: a genotype-phenotype analysis.
- Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's Disease.
- O-015 YI Alterations in the FOXP3-EZH2 Pathway Associates with Increased Susceptibility to Colitis in Both Mice and Human.
- O-011 Paneth Cell Phenotypes Define a Subtype of Pediatric Crohn's Disease Through Alterations in Host-Microbial Interactions.
- Flow Cytometric Analysis of Mononuclear Phagocytes in Non-Diseased Human Lung and Lung-draining Lymph Nodes.
- Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.
- Growth dynamics of gut microbiota in health and Disease inferred from single metagenomic samples.
- The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.
- Disease-specific alterations in the enteric virome in inflammatory bowel Disease.
- Systems immunology reveals markers of susceptibility to West Nile virus infection.
- BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
- Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.
- Autophagy and checkpoints for intracellular pathogen defense.
- An alteration in ATG16L1 stability in Crohn Disease.
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.
- mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
- Small-molecule control of cytokine function: new opportunities for treating immune disorders.
- Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
- Inflammatory Bowel Disease as a Model for Translating the Microbiome.
- Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.
- Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
- Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.
- Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases.
- The Intestinal microbiome in type 1 diabetes.
- The treatment-naive microbiome in new-onset Crohn's Disease.
- The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.
- Autophagy is essential for cardiac morphogenesis during vertebrate development.
- SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's Disease.
- Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.
- Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection.
- Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL.
- Autophagy at the crossroads of metabolism and cellular defense.
- Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
- Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules.
- Advances in inflammatory bowel Disease pathogenesis: linking host genetics and the microbiome.
- Latent gammaherpesvirus 68 infection induces distinct transcriptional changes in different organs.
- Genetic risk factors for Clostridium difficile infection in Ulcerative colitis.
- Genetic Variants Synthesize to Produce Paneth Cell Phenotypes that Define Subtypes of Crohn's Disease.
- Card9 mediates Intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice.
- Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism.
- Functional profiling of the gut microbiome in Disease-associated inflammation.
- Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation.
- How Does Genotype Influence Disease Phenotype in Inflammatory Bowel Disease?
- Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer.
- From genetics of inflammatory bowel Disease towards mechanistic insights.
- Genome-wide Analysis of Immune System Genes by Expressed Sequence Tag Profiling.
- Polarity gene discs large homolog 1 regulates the generation of memory T cells.
- ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.
- Identification of a candidate therapeutic autophagy-inducing peptide.
- Cutting Edge: Cell-Autonomous Control of IL-7 Response Revealed in a Novel Stage of Precursor B Cells.
- Mutations causing medullary cystic kidney Disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.
- Angiotensin II Drives the Production of Tumor-Promoting Macrophages.
- ATG5 regulates plasma cell differentiation.
- Common alleles that influence autophagy and the risk for inflammatory bowel Disease.
- Enhanced Tim3 Activity Improves Survival after Influenza Infection.
- Case records of the Massachusetts General Hospital. Case 23-2012. A 59-year-old man with abdominal pain and Weight loss.
- Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel Disease.
- Helminth Infection Impairs Autophagy-Mediated Killing of Bacterial Enteropathogens by Macrophages.
- Autophagy and the immune System.
- Regulation of monocyte functional heterogeneity by miR-146a and Relb.
- Establishment and characterization of a novel chordoma cell line: CH22.
- Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.
- CARMA1 Is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma.
- Image-based genome-wide siRNA screen identifies selective autophagy factors.
- Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of Ulcerative colitis patients.
- Leucine-rich repeat (LRR) proteins: Integrators of pattern recognition and signaling in immunity.
- A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.
- MyD88-Dependent TLR1/2 Signals Educate Dendritic Cells with Gut-Specific Imprinting Properties.
- NLRP3 inflammasome plays a key role in the regulation of Intestinal homeostasis.
- Bacterial and Host Determinants of MAL Activation upon EPEC Infection: The Roles of Tir, ABRA, and FLRT3.
- Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
- Meta-analysis identifies 29 additional Ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
- HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
- Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.
- Corrigendum: Meta-analysis identifies 29 additional Ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
- Recurrent chromosomal copy number alterations in sporadic chordomas.
- LRRK2 is involved in the IFN-gamma response and host response to pathogens.
- Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic su...
- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's Disease.
- Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
- Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.
- A Systems biology viewpoint on autophagy in health and disease.
- A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.
- Characterization and analysis of human chordoma cell lines.
- Crohn Disease: A current perspective on genetics, autophagy and immunity.
- Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions.
- Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel Diseases.
- The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
- Autophagy, immunity and human Disease.
- A genome-wide genetic screen for host factors required for hepatitis C virus propagation.
- The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.
- A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.
- A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.
- CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.
- HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.
- On the level: IRGM gene function is all about expression.
- Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.
- Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
- Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's Disease.
Schools
School Of Med University Of Zimbabwe
Harare Cen Hospital
Massachusetts General Hospital
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
Conditions Treated
- Anemia
- Benign Neoplasm of the Digestive System
- Crohn's Disease (Regional Enteritis)
- Esophageal Achalasia and Cardiospasm
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Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Fellow (AGAF)
- Super Doctor
Education
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Massachusetts General Hospital -
University of Zimbabwe Huggins School of Medicine
Hospital
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Massachusetts General Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1275523359 |
| Last Name Of The Provider | XAVIER |
| First Name Of The Provider | RAMNIK |
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