The Children's Hospital of Philadelphia
Pediatric Gastroenterology
Dr. Randolph P. Matthews, MD
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Randolph P. Matthews, MD practices Pediatric Gastroenterology. He attended University of Washington School of Medicine. Randolph P. Matthews is also published. He has 22 publications published. The lastest publication: "p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis.'
Publications
- Interferon-Gamma Directly Mediates Developmental Biliary Defects.
- Evidence from Human and Zebrafish that GPC1 is a Biliary Atresia Susceptibility Gene.
- Cholangiocarcinoma in a Young Woman with Perinatally Acquired HIV.
- Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish.
- Significant liver Disease in a patient with Y116H mutation in the MVK gene.
- Disruption of planar cell polarity activity leads to developmental biliary defects.
- DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia.
- Intrahepatic biliary anomalies in a patient with Mowat-Wilson syndrome uncover a role for the zinc finger homeobox gene zfhx1b in vertebrate biliary development.
- Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization.
- The microRNA-30 family is required for vertebrate hepatobiliary development.
- Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish.
- The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary development.
- Cases in pediatric gastroenterology from The Children's Hospital of Philadelphia. A 5-year-old girl with massive hepatosplenomegaly, fever, and rash.
- A 1-month-old with prolonged jaundice.
- Biliary atresia associated with a fatty acid oxidation defect.
- p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis.
- CCBE1 Mutation in Two Siblings, One Manifesting Lymphedema-Cholestasis Syndrome, and the Other, Fetal Hydrops.
- Group C streptococcal meningitis: case report and review of the literature.
- Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the ...
- Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy.
- TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.
Schools
University of Washington
Children39s Hospital Philadelphia
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Anemia
- Crohn's Disease (Regional Enteritis)
- Gastroesophageal Reflux Disease (GERD)
- Gastroparesis
- View All
Doctors Specialties
- Pediatric Gastroenterology
Accepted Insurances
Education
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Children's Hospital of Philadelphia -
University of Washington School of Medicine
Hospital
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Hospital of the University of Pennsylvania -
Pennsylvania Hospital
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