Professor, Internal Medicine, University of Texas Southwestern Medical Center, Southwestern Medical School
Gastroenterology
Dr. Rhonda F. Souza, MD
|
|
Give Review
Rhonda F. Souza practices Gastroenterology. He attended Howard University College of Medicine. He received awards:"Fellow (AGAF)". Rhonda Souza is a published doctor as well. He has 99 publications published. The latest was: Anti-p53 antibodies in patients with Barrett's esophagus or esophageal carcinoma can predate cancer diagnosis.
Publications
- Quality Indicators for the Management of Barrett's Esophagus, Dysplasia, and Esophageal Adenocarcinoma: International Consensus Recommendations from the American Gastr...
- Prohibitin 1 modulates mitochondrial function of Stat3.
- Eosinophilic Esophagitis: Interactions with Gastroesophageal Reflux Disease.
- In Barrett's Esophagus Patients and Barrett's Cell Lines, Ursodeoxycholic Acid Increases Antioxidant Expression and Prevents DNA Damage by Bile Acids.
- EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma.
- Development and Characterization of a Surgical Mouse Model of Reflux Esophagitis and Barrett's Esophagus.
- Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.
- Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway.
- Phospho-mTOR is not upregulated in metastatic SDHB paragangliomas.
- Role of NADPH Oxidase NOX5-S, NF-kB and DNMT1 in Acid-Induced P16 Hypermethylation in Barrett's cells.
- In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-κB and activator protein-1.
- MicroRNA Expression Differentiates Squamous Epithelium from Barrett's Esophagus and Esophageal Cancer.
- Introduction to the "GRG Scholars Invited Reviews"
- Acid burn or cytokine sizzle in the pathogenesis of heartburn?
- Esophageal human beta-defensin expression in eosinophilic esophagitis.
- Omeprazole Blocks STAT6 Binding to the Eotaxin-3 Promoter in Eosinophilic Esophagitis Cells.
- Tissue Remodeling in Eosinophilic Esophagitis.
- Targeting the Intrinsic Inflammatory Pathway: Honokiol Exerts Pro-Apoptotic Effects through STAT3 Inhibition in Transformed Barrett's Cells.
- The pathogenesis of Gastroesophageal reflux disease.
- Trains, Tracks, and Promotion in an Academic Medical Center.
- Esophageal stem cells and 3D-cell culture models.
- Barrett's esophagus: genetic and cell changes.
- GRG Update: DDW 2011.
- Deoxycholic Acid Causes DNA Damage while Inducing Apoptotic Resistance through NF-{kappa}B Activation in Benign Barrett's Epithelial Cells.
- Durability of radiofrequency ablation in Barrett's esophagus with dysplasia.
- Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells.
- Biology of Barrett's esophagus and esophageal adenocarcinoma.
- Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S.
- Bringing GERD Management up to PAR-2.
- Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus.
- The molecular basis of carcinogenesis in Barrett's esophagus.
- Biomarkers in Barrett's Esophagus.
- Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro.
- Malignant transformation of non-neoplastic Barrett's epithelial cells through well-defined genetic manipulations.
- In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double-strand breaks.
- Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury.
- Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications.
- Molecular markers and genetics in cancer development.
- Multilayered epithelium in mucosal biopsy specimens from the Gastroesophageal junction region is a histologic marker of Gastroesophageal reflux disease.
- Radiofrequency ablation in Barrett's esophagus with dysplasia.
- Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway.
- Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus.
- Acid, bile, and CDX: the ABCs of making Barrett's metaplasia.
- Biomarkers and photodynamic therapy for Barrett's esophagus: time to FISH or cut bait?
- Stem cells in Barrett's esophagus: HALOs or horns?
- Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line.
- Mechanisms of oxidant production in esophageal squamous cell and Barrett's cell lines.
- In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway.
- GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus.
- Thoughts on the complex relationship between Gastroesophageal reflux disease and eosinophilic esophagitis.
- NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells.
- All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells.
- Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells.
- Is genomic evaluation feasible in endoscopic studies of Barrett's esophagus? A pilot study.
- Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus.
- Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line.
- Acid increases MAPK-mediated proliferation in Barrett's esophageal adenocarcinoma cells via intracellular acidification through a Cl-/HCO3- exchanger.
- Concepts in the prevention of adenocarcinoma of the distal esophagus and proximal stomach.
- Differences in ERK activation in squamous mucosa in patients who have Gastroesophageal reflux disease with and without Barrett's esophagus.
- Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins.
- Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells.
- Barrett's esophagus: chemoprevention.
- p47phox participates in activation of RelA in endothelial cells.
- Activation of the esophagin promoter during esophageal epithelial cell differentiation.
- Molecular and biologic basis of upper gastrointestinal malignancy--esophageal carcinoma.
- Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus.
- TNFalpha activates c-Jun amino terminal kinase through p47(phox).
- Assessment of oxidants in mitogen-activated protein kinase activation.
- Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells.
- American Gastroenterological Association technical review on the management of Barrett''s esophagus.
- American Gastroenterological Association medical position statement on the management of Barrett''s esophagus.
- Biomarkers and molecular diagnosis of gastrointestinal and pancreatic neoplasms.
- The role of acid and bile Reflux in oesophagitis and Barrett''s metaplasia.
- Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma.
- Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer.
- Esophageal adenocarcinoma arising in Barrett esophagus.
- Induction of colonic epithelial cell apoptosis by p47-dependent oxidants.
- Hallmarks of cancer progression in Barrett''s oesophagus.
- Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells.
- Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus.
- Molecular targets for treatment of Barrett''s esophagus.
- Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett''s esophagus.
- Gene expression in Barrett''s esophagus: laser capture versus whole tissue.
- A transforming growth factor beta 1 receptor type II mutation in Ulcerative colitis-associated neoplasms.
- Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal Reflux disease and related neoplasia.
- Anti-p53 antibodies in patients with Barrett's esophagus or esophageal carcinoma can predate cancer diagnosis.
- The molecular basis for carcinogenesis in metaplastic columnar-lined esophagus.
- Loss of transforming growth factor-beta type II receptor gene expression in primary human esophageal cancer.
- Characterization of telomerase-immortalized, non-neoplastic, human Barrett''s cell line (BAR-T).
- Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett''s oesophagus.
- Alterations of transforming growth factor-beta 1 receptor type II occur in Ulcerative colitis-associated carcinomas, sporadic colorectal neoplasms, and esophageal carc...
- A molecular rationale for the how, when and why of colorectal cancer screening.
- Heartburn in patients with achalasia.
- Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells.
- Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors.
- Microsatellite Analysis of the Insulin-Like Growth Factor II Receptor in Colorectal Carcinomas.
- Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers.
- Molecular mechanisms of acid exposure in Barrett''s esophagus.
Schools
Howard University
Beth Israel Hospital
University MD
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Gastroesophageal Reflux Disease (GERD)
- Hemorrhoids
- Ulcerative Colitis
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Fellow (AGAF)
Education
-
University of Maryland -
Beth Israel Deaconess Medical Center -
Howard University College of Medicine
Hospital
-
University of Texas Southwestern Medical Center -
Veterans Affairs North Texas Health Care System
Helpful Reviews
Similar Doctors
|
|
Dr. Lisa C. Casey, MD |
|
|
Dr. Noel L. Snowberger, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Carmen E. Landaverde, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Howard J. Weiner, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Daniel E. Polter, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Kurt C. Lange, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Esmail Elwazir, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Robert P. Perrillo, MD
This Doctor is OpenDoctor Recommended.
 This doctor has more publications
|
|
|
Dr. Samar Harris, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Amit H. Masand, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Rohit Sharda, MD
This Doctor is OpenDoctor Recommended.
|
|
|
David B. Langdon
This Doctor is OpenDoctor Recommended.
|