Director of the Kimmel Cancer Center at Thomas Jefferson University
Endocrinology
Dr. Richard G. Pestell, MD
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Richard Pestell is an expert in the field of Endocrinology. He over the years received 1 awards: "Elected Member". Richard G. Pestell is a published MD. He has 99 papers published. The most current publication "Mitochondrial mass and DNA repair in breast cancer stem cells."
Publications
- Mitochondrial mass and DNA repair in breast cancer stem cells.
- EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
- BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion.
- The potential to target CCL5/CCR5 in breast cancer.
- The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells.
- Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.
- Cyclin d1 integrates estrogen-mediated DNA damage repair signaling.
- The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster.
- Cell Fate Factor DACH1 Represses YB-1-Mediated Oncogenic Transcription and Translation.
- CAPER, a novel regulator of human breast cancer progression.
- Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present.
- Long and noncoding RNAs (lnc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo.
- Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint.
- Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer.
- MicroRNAs and cancer stem cells: the sword and the shield.
- Cyclin d1 determines estrogen signaling in the mammary gland in vivo.
- EYA1 Phosphatase Function Is Essential to Drive Breast Cancer Cell Proliferation through Cyclin D1.
- New roles of cyclin D1.
- Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFkB target stromal MCT4.
- Caloric restriction augments radiation efficacy in breast cancer.
- Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity.
- Compartment-specific activation of PPAR? governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.
- Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide.
- Nutrient restriction and radiation therapy for cancer treatment: when less is more.
- Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures.
- Cav1 Suppresses Tumor Growth and Metastasis in a Murine Model of Cutaneous SCC through Modulation of MAPK/AP-1 Activation.
- Cyclins and cell cycle control in cancer and disease.
- Metabolic reprogramming and two-compartment tumor metabolism: Opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
- CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase i...
- Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth.
- Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate p...
- CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells.
- Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment: Chemoprevention with Rapamycin, an mTOR Inhibitor and Anti-Aging Drug.
- Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells.
- Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production.
- CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.
- Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration.
- Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases.
- Mitochondrial metabolism in cancer metastasis: Visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue.
- Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism.
- Breast cancer stem cells.
- Mammary gland selective excision of c-jun identifies its role in mRNA splicing.
- Energy transfer in "parasitic" cancer metabolism: Mitochondria are the powerhouse and Achilles' heel of tumor cells.
- Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: Implications for preventing chemoth...
- Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
- Mitochondrial oxidative stress in cancer associated fibroblasts drives lactate production, promoting breast cancer tumor growth: Understanding the aging and cancer con...
- Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue.
- SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA.
- Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis.
- Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.
- Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition.
- Hormonal Therapy Promotes Hormone-Resistant Phenotype by Increasing DNMT Activity and Expression in Prostate Cancer Models.
- Understanding the metabolic basis of drug resistance: Therapeutic induction of the Warburg effect kills cancer cells.
- Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: The seed and soil also needs "fertilizer"
- Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: Implications for PET imaging of human tumors.
- Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment.
- The role of breast cancer stem cells in metastasis and therapeutic implications.
- Accelerated aging in the tumor microenvironment: Connecting aging, inflammation and cancer metabolism with personalized medicine.
- Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis.
- Cytokine production and inflammation drive autophagy in the tumor microenvironment: Role of stromal caveolin-1 as a key regulator.
- Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.
- Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Met...
- Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis, and poor clinical outcome in breast cancer: Achieving personalized medicine via Me...
- Mechanisms for Progenitor Cell-mediated Repair for Ischemic Heart Injury.
- Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated ...
- Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
- Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms.
- Cell fate determination factor Dachshund reprograms breast cancer stem cell function.
- MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals.
- PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b.
- Analysis of nuclear receptor acetylation.
- Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1.
- The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.
- C-jun inhibits mammary apoptosis in vivo.
- The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox.
- Alternative cyclin D1 splice forms differentially regulate the DNA damage response.
- CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway.
- Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
- HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific onco...
- The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.
- Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.
- Dietary restriction: standing up for sirtuins.
- Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic ins...
- 5-Azacitidine restores and amplifies the bicalutamide response on preclinical models of androgen receptor expressing or deficient prostate tumors.
- Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic c...
- Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors.
- Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a ...
- The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
- microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling.
- Attenuation of Forkhead signaling by the retinal determination factor DACH1.
- Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheim...
- c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.
- Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells.
- microRNA, cell cycle, and human breast cancer.
- BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha.
- Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products.
- The Dachshund gene in development and hormone-responsive tumorigenesis.
- Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis.
Doctors Specialties
- Oncology
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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University of Western Australia Faculty of Medicine
Hospital
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Thomas Jefferson University Hospital
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