Professor, Anesthesiology, Washington University in St. Louis School of Medicine
Anesthesiology
Dr. Richard S. Hotchkiss, MD
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Richard Hotchkiss practices Anesthesiology. He studied medicine at University of Virginia School of Medicine. Richard Hotchkiss is a published MD. He published 97 publications, including: 'Understanding why clinicians should care about danger-associated molecular patterns.' Doctor Richard S. Hotchkiss, MD accepts Medicare payments and is listed with Medicare.gov.
Publications
- The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
- Understanding why clinicians should care about danger-associated molecular patterns.
- Imaging Apoptosis in Sepsis-A Technology We Would Die for!
- Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.
- Immunology. Getting sepsis therapy right.
- The Presence of Hypothermia Within 24 Hours of Sepsis Diagnosis Predicts Persistent Lymphopenia.
- Persistent lymphopenia after diagnosis of sepsis predicts mortality.
- The new normal: immunomodulatory agents against sepsis immune suppression.
- Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.
- Reply: The Role of Arrhythmias in Defining Cardiac Dysfunction during Sepsis.
- The changing immune system in sepsis: Is individualized immuno-modulatory therapy the answer?
- Blockade ofthe negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis.
- Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.
- Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis.
- Immunosuppression in patients who die of sepsis and multiple organ failure.
- Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes.
- Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.
- Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.
- Advances in the Management of Sepsis and the Understanding of Key Immunologic Defects.
- Cecal Ligation and Puncture Followed by MRSA Pneumonia Increases Mortality in Mice and Blunts Production of Local and Systemic Cytokines.
- Change in Temperature Profile May Precede Fever and be an Early Indicator of Sepsis: A Case Report.
- Dose Dependent Effect of Anti-CTLA-4 on Survival in Sepsis.
- The first step in utilizing immune-modulating therapies: immune status determination.
- Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.
- Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis.
- A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.
- Immunotherapy for sepsis--a new approach against an ancient foe.
- Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism.
- Characterization and modulation of the immunosuppressive phase of sepsis.
- IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.
- Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis.
- IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.
- Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis.
- Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses.
- Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis.
- Cell death.
- Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma.
- Targeted delivery of siRNA to cell death proteins in sepsis.
- Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
- CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis.
- An anti-apoptotic peptide improves survival in lethal total body irradiation.
- Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study.
- The sepsis seesaw: tilting toward immunosuppression.
- Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.
- Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury.
- Effects of aging on the immunopathologic response to sepsis.
- Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.
- Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis.
- Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis.
- Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis.
- Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.
- Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.
- Lymphocyte phenotyping to distinguish septic from nonseptic critical illness.
- Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.
- Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy.
- TAT-Bim induces extensive apoptosis in cancer cells.
- Anti-apoptotic peptides protect against radiation-induced cell death.
- Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo.
- Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis.
- Adoptive transfer of dying cells causes bystander-induced apoptosis.
- Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections.
- The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.
- Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis.
- Molecular diagnostics in sepsis: from bedside to bench.
- Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis.
- Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis.
- Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis.
- TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.
- Prevention of lymphocyte apoptosis--a potential treatment of sepsis?
- Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels.
- Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury.
- Iron dysregulation combined with aging prevents sepsis-induced apoptosis.
- Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways.
- Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium.
- Sequence makes a difference: paradoxical effects of stress in vivo.
- Akt decreases lymphocyte apoptosis and improves survival in sepsis.
- High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apopto...
- Endothelial cell apoptosis in sepsis: a case of habeas corpus?
- Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels.
- Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival.
- Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells.
- Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.
- Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest.
- Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis.
- Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia.
- Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.
- Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells.
- The pathophysiology and treatment of sepsis.
- Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays.
- Endothelial cell apoptosis in sepsis.
- Myeloperoxidase produces nitrating oxidants in vivo.
- Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis.
- Depletion of dendritic cells, but not macrophages, in patients with sepsis.
- Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice.
- Reactivation of multiple viruses in patients with sepsis.
- Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury.
Schools
University of Virginia Main Campus
Grady Mem Hospital
Mass Gen Hospital
University Of Va Med Center
Doctors Specialties
- Critical Care Medicine
- Anesthesiology
Accepted Insurances
Education
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Massachusetts General Hospital -
University of Virginia School of Medicine
Hospital
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Barnes-Jewish Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1467479998 |
| Last Name Of The Provider | HOTCHKISS |
| First Name Of The Provider | RICHARD |
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