President, CEO and Chaiman, Midway Pharmaceuticals, Inc.

Gastroenterology

Dr. Rifat Pamukcu, MD

Rifat Pamukcu is an expert in the field of Gastroenterology. He went to medical school at University of Wisconsin School of Medicine and Public Health. Rifat Pamukcu is a published doctor. He has 36 papers published. The most current publication "Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis."

Publications

Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.
Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival.
beta-Catenin signaling: therapeutic strategies in oncology.
Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G.
CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.
Rapid development of colitis in NSAID-treated IL-10-deficient mice.
Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation.
Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors.
Preclinical and clinical studies of docetaxel and exisulind in the treatment of human lung cancer.
Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase.
Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.
Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis.
Proapoptotic anti-inflammatory drugs.
Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.
Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.
Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis.
Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.
Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis.
Inhibition of angiogenesis by sulindac and its sulfone metabolite (FGN-1): a potential mechanism for their antineoplastic properties.
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone).
Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines.
A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes.
Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.
Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, ce...
Sulfone metabolite of sulindac inhibits mammary carcinogenesis.
Determination of FGN-1 (an active metabolite of sulindac) in human plasma, urine, and feces by HPLC.
Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte.
Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells.
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.
Inhibition of mammary carcinogenesis in rats by sulfone metabolite of sulindac.
Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole.
Idiopathic acute interstitial nephritis: characterization of the infiltrating cells in the renal interstitium as T helper lymphocytes.
Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicylic acid.

Schools

University of Wisconsin Madison

Doctors Specialties

Internal Medicine
Gastroenterology

Accepted Insurances

Education

University of Chicago
Rush University Medical Center
University of Wisconsin School of Medicine and Public Health

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