Physician
General Surgery
Dr. Robert A. Hawkins, MD
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Robert Hawkins practices General Surgery. He researched medicine at Albany Medical College. He received awards:"Fellow (FACS)". Robert Hawkins is also published. He has 101 publications published. The lastest publication: "Chemotherapy for ovarian cancer--trials, controversies and funding.'
Publications
- Expanded subpopulation of FoxP3(+) T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs.
- MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients.
- Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells.
- High-dose interleukin-2 can produce a high rate of response and durable remissions in appropriately selected patients with metastatic renal cancer.
- Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding.
- Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study.
- Functional expression of secreted proteins from a bicistronic retroviral cassette based on foot-and-mouth disease virus 2A can be position dependent.
- Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells has caused serious adverse events.
- The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogeno...
- Development of a flow cytometric co-immunoprecipitation technique for the study of multiple protein-protein interactions and its application to T-cell receptor analysis.
- Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma.
- Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial.
- Natural expression of the CD19 antigen impacts the long-term engraftment but not antitumor activity of CD19-specific engineered T cells.
- T cell-based immunotherapy of metastatic renal cell carcinoma: modest success and future perspective.
- Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-alpha.
- Eradication of established B-cell lymphoma by CD19-specific murine T cells is dependent on host lymphopenic environment and can be mediated by CD4+ and CD8+ T cells.
- An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.
- Eotaxin-2 and colorectal cancer: a potential target for immune therapy.
- Patients with pancreatic cancer participating in clinical trials: are targets being met, and if not, why?
- CD8 T-cell recognition of human 5T4 oncofetal antigen.
- Combination of vaccination and chimeric receptor expressing T cells provides improved active therapy of tumors.
- Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease...
- A phase II study of weekly cisplatin and gemcitabine in patients with advanced pancreatic cancer: is this a strategy still worth pursuing?
- Safety and tolerability of PCK3145, a synthetic peptide derived from prostate secretory protein 94 (PSP94) in metastatic hormone-refractory prostate cancer.
- The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens.
- Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma.
- Adoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma.
- Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.
- Antibody-directed enzyme-prodrug therapy.
- Gene therapy of patient-derived T lymphocytes to target and eradicate colorectal hepatic metastases.
- Immunization with a recombinant adenovirus encoding a lymphoma idiotype: induction of tumor-protective immunity and identification of an idiotype-specific T cell epitope.
- Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors.
- Accelerated hyperfractionation radiation therapy after lumpectomy and axillary lymph node dissection in patients with stage I or II breast cancer: pilot study.
- Modulation of thrombospondin expression during differentiation of embryonal carcinoma cells.
- The Football Association Medical Research Programme: an audit of injuries in professional football-analysis of preseason injuries.
- Positron emission tomography with f18-fluorodeoxyglucose in the staging and preoperative evaluation of malignant pleural mesothelioma.
- Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours.
- Making antibodies by phage display technology.
- Selection of phage antibodies by binding affinity. Mimicking affinity maturation.
- Principles of antibody therapy.
- Association of mycoplasma and human immunodeficiency virus infection: detection of amplified Mycoplasma fermentans DNA in blood.
- The human antibody library.
- Cimetidine in colorectal cancer--are the effects immunological or adhesion-mediated?
- The contribution of contact and non-contact residues of antibody in the affinity of binding to antigen. The interaction of mutant D1.3 antibodies with lysozyme.
- Chemotherapy for ovarian cancer--trials, controversies and funding.
- Efficient transgene regulation from a single tetracycline-controlled positive feedback regulatory system.
- Adjuvant therapy for melanoma: How should we respond to high-dose interferon?
- Cell selection strategies for making antibodies from variable gene libraries: trapping the memory pool.
- A comparative study of intravenous versus intralymphatic interleukin-2, with assessment of effects of interleukin-2 on both peripheral blood and thoracic-duct lymph.
- Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues.
- Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display.
- Integrin-mediated epithelial-T cell interaction enhances nitric oxide production and increased intracellular inhibition of Chlamydia.
- A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.
- Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion pr...
- Ifosfamide with and without adriamycin in advanced uterine leiomyosarcoma.
- Retroviral vectors displaying functional antibody fragments.
- The clinical and histologic criteria that predict metastases from cystosarcoma phyllodes.
- Recombinant adenoviral delivery for in vivo expression of scFv antibody fusion proteins.
- A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectabl...
- Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study.
- A genetic approach to idiotypic vaccination.
- The 'adenobody' approach to viral targeting: specific and enhanced adenoviral gene delivery.
- Idiotypic DNA vaccines against B-cell lymphoma.
- Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors.
- A postcode lottery still exists for cancer patients with 'exceptional circumstances'.
- Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial.
- Targeting of adenovirus to endothelial cells by a bispecific single-chain diabody directed against the adenovirus fiber knob domain and human endoglin (CD105).
- Antibodies: from genes to targeted cancer gene therapy.
- A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer.
- Impact of laparotomy and liver resection on the peritoneal concentrations of fibroblast growth factor 2, vascular endothelial growth factor and hepatocyte growth factor.
- Vaccines in oncology: background and clinical potential.
- Targeted cytokine delivery to neuroblastoma.
- Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines.
- Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer.
- Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis.
- Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell line.
- Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes.
- European School of Oncology Task Force Report. New approaches in cancer pharmacology: drug design and development (Part 2).
- Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with...
- Lapatinib versus hormone therapy in patients with advanced renal cell carcinoma: a randomized phase III clinical trial.
- The impact of primary tumour origins in patients with advanced oesophageal, oesophago-gastric junction and gastric adenocarcinoma--individual patient data from 1775 pa...
- Technetium-99m radiolabeling using a phage-derived single-chain Fv with a C-terminal cysteine.
- Phase III trial of 5-fluorouracil and leucovorin plus either 3H1 anti-idiotype monoclonal antibody or placebo in patients with advanced colorectal cancer.
- Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library.
- A pilot study of idiotypic vaccination for follicular B-cell lymphoma using a genetic approach. CRC NO: 92/33. Protocol NO: PH1/027.
- Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease r...
- Clinical issues in antibody design.
- Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography.
- A genetic approach to idiotypic vaccination for B cell lymphoma.
- A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis.
- Cancer vaccines: a clinical perspective.
- Phase II study of troxacitabine in chemotherapy-naive patients with advanced cancer of the pancreas: gastrointestinal tumors.
- A phase II study of a 5T4 oncofoetal antigen tumour-targeted superantigen (ABR-214936) therapy in patients with advanced renal cell carcinoma.
- Management of a new isolated metastasis during sunitinib treatment in renal cell carcinoma patients: a lesson from two cases.
- Pharmacological control of antigen responsiveness in genetically modified T lymphocytes.
- Sunitinib in metastatic renal cell carcinoma patients with brain metastases.
- Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine.
- A single chain Fv derived from a filamentous phage library has distinct tumor targeting advantages over one derived from a hybridoma.
- Production and tumour-binding characterization of a chimeric anti-CEA Fab expressed in Escherichia coli.
- Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy.
Schools
Brown University Alpert Medical School
Roger Williams Hospital
University Of MD Med Sys
Doctors Specialties
- Diagnostic Radiology
- General Surgery
Accepted Insurances
Awards
- Fellow (FACS)
Education
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Maine Medical Center -
Albany Medical College
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