Physician
Allergy & Immunology
Dr. Robert A. Seder, MD
Robert Seder is an expert in the field of Allergy & Immunology. He has 1 awards "Elected Member". Doctor Robert A. Seder, MD has written publications. He has 99 publications published with PubMed. The lastest paper is: 'Cytokines are critical in linking the innate and adaptive immune responses to bacterial, fungal, and parasitic infection.'
Publications
- In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity.
- Combination recombinant simian or chimpanzee adenoviral vectors for vaccine development.
- Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.
- Dendritic cell-targeted vaccines - hope or hype?
- A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine.
- Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails To Protect against High-Dose Mycobacterium tuberc...
- A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 Vaccine: Evidence for transient t cell responses in peripheral blo...
- Toll-Like Receptor 7/8 (TLR7/8) and TLR9 Agonists Cooperate To Enhance HIV-1 Envelope Antibody Responses in Rhesus Macaques.
- Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.
- Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants.
- Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific...
- Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine.
- Polyinosinic-Polycytidylic Acid Is the Most Effective TLR Adjuvant for SIV Gag Protein-Induced T Cell Responses In Nonhuman Primates.
- Full-Length Plasmodium falciparum Circumsporozoite Protein Administered with Long-Chain Poly(I{middle dot}C) or the Toll-Like Receptor 4 Agonist Glucopyranosyl Lipid A...
- Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-...
- SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.
- Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.
- IFN-{alpha} produced by human plasmacytoid dendritic cells enhances T cell-dependent naive B cell differentiation.
- Genetic immunization in the lung induces potent local and systemic immune responses.
- Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire.
- Vaccine adjuvants: putting innate immunity to work.
- CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requireme...
- IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform.
- Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells.
- Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells.
- IFN-gamma mediates the death of Th1 cells in a paracrine manner.
- Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major.
- IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection.
- Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates.
- HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.
- Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs.
- Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses.
- Memory may not need reminding.
- Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses.
- Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and ...
- Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its p...
- Similarities and differences in CD4+ and CD8+ effector and memory T cell generation.
- Dendritic cells are responsible for the capacity of CpG oligodeoxynucleotides to act as an adjuvant for protective vaccine immunity against Leishmania major in mice.
- Immunological and pathological evaluation of rhesus macaques infected with Leishmania major.
- Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon expressing antigen 85A.
- Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.
- Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell response...
- CpG oligodeoxynucleotides as vaccine adjuvants in primates.
- Adoptive chemoimmunotherapy for the treatment of relapsed and refractory solid tumors using ex vivo activated memory T cells (autolymphocyte therapy) and cyclophospham...
- Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologou...
- Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.
- Dendritic cells as immunogens for human CTL responses.
- Influence of novel CD4 binding-defective HIV-1 envelope glycoprotein immunogens on neutralizing antibody and T-cell responses in nonhuman primates.
- Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.
- The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses.
- Live attenuated malaria vaccine designed to protect through hepatic CD8? T cell immunity.
- Regulation of transforming growth factor-beta production by interleukin-12.
- Are differentiated human T helper cells reversible?
- Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum.
- Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses.
- The role of IL12 in the regulation of Th1 and Th2 differentiation.
- Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease.
- High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4+ T cells for IFN-gamma but have differential effects on priming for IL-4.
- IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro.
- Induction and regulation of IL-15 expression in murine macrophages.
- Ultrastructural characteristics of Fc epsilon R-positive basophils in the spleen and bone marrow of mice immunized with goat anti-mouse IgD antibody.
- Lymphokine and cytokine production by Fc epsilon RI+ cells.
- Production of interleukin-4 and other cytokines following stimulation of mast cell lines and in vivo mast cells/basophils.
- Purified Fc epsilon R+ bone marrow and splenic non-B, non-T cells are highly enriched in the capacity to produce IL-4 in response to immobilized IgE, IgG2a, or ionomycin.
- Increased frequency of interleukin 4-producing T cells as a result of polyclonal priming. Use of a single-cell assay to detect interleukin 4-producing cells.
- Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.
- Activation events during thymic selection.
- CD8+ T cells can be primed in vitro to produce IL-4.
- The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.
- Fc epsilon receptor-positive cells are a major source of antigen-induced interleukin-4 in spleens of mice infected with Schistosoma mansoni.
- CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.
- Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement.
- Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced h...
- Acquisition of lymphokine-producing phenotype by CD4+ T cells.
- Lymphocyte responses and cytokines.
- Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.
- Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.
- The functional role of CD8+ T helper type 2 cells.
- IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma.
- Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15.
- T helper cell differentiation in immune response.
- Effects of interleukin-3 with or without the c-kit ligand, stem cell factor, on the survival and cytoplasmic granule formation of mouse basophils and mast cells in vitro.
- The NZB X SWR model of lupus nephritis. I. Cross-reactive idiotypes of monoclonal anti-DNA antibodies in relation to antigenic specificity, charge, and allotype. Ident...
- Vaccines against intracellular infections requiring cellular immunity.
- CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-inf...
- DNA vaccines: a key for inducing long-term cellular immunity.
- The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an in...
- Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells.
- DNA vaccines: immunology, application, and optimization*.
- Cytokine regulation of IL-12 receptor beta2 expression: differential effects on human T and NK cells.
- CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis.
- Dealing from the evolutionary pawnshop: how lymphocytes make decisions.
- DNA vaccines--designer vaccines for the 21st century.
- Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent a...
- Cytokines are critical in linking the innate and adaptive immune responses to bacterial, fungal, and parasitic infection.
- Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-gamma.
- Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection.
- CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge.
Schools
Tufts University
Doctors Specialties
- Internal Medicine
- Allergy
- Immunology
Accepted Insurances
Awards
- Elected Member
Helpful Reviews
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