Professor, Psychiatry and Behavioral Science, Stanford University Medical Center
Psychiatry
Dr. Robert C. Malenka, MD
Robert Malenka practices Psychiatry. He has 2 awards "Elected Member" and "Whos Who in Medicine and Healthcare". Robert C. Malenka, MD has written publications. He has 100 publications published with PubMed. The lastest publication is: 'Input- and Output-Specific Regulation of Serial Order Performance by Corticostriatal Circuits.'
Publications
- Input- and Output-Specific Regulation of Serial Order Performance by Corticostriatal Circuits.
- Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits.
- Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping.
- β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.
- B-lymphocyte-mediated delayed cognitive impairment following stroke.
- Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons.
- Depression: the best way forward.
- The emerging role of nucleus accumbens oxytocin in social cognition.
- Illuminating circuitry relevant to psychiatric disorders with optogenetics.
- Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.
- Natural neural projection dynamics underlying social behavior.
- Behavioral Abnormalities and Circuit Defects in the Basal Ganglia of a Mouse Model of 16p11.2 Deletion Syndrome.
- Ionotropic NMDA Receptor Signaling Is Required for the Induction of Long-Term Depression in the Mouse Hippocampal CA1 Region.
- Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release.
- Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.
- Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation.
- Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking.
- Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling.
- Reward and aversion in a heterogeneous midbrain dopamine system.
- Diverging neural pathways assemble a behavioural state from separable features in anxiety.
- LTP Requires a Unique Postsynaptic SNARE Fusion Machinery.
- {triangleup}FosB differentially modulates nucleus accumbens direct and indirect pathway function.
- Input-specific control of reward and aversion in the ventral tegmental area.
- Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease.
- Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens.
- A Comparison of Striatal-Dependent Behaviors in Wild-Type and Hemizygous Drd1a and Drd2 BAC Transgenic Mice.
- Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus.
- Integrating synaptic plasticity and striatal circuit function in addiction.
- QnAs with Robert C. Malenka.
- The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo.
- Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.
- Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons.
- Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli.
- Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling.
- Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.
- Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens.
- A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression.
- LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation.
- Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain.
- A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors.
- Coordinated changes in dendritic arborization and synaptic strength during neural circuit development.
- Functional engraftment of the medial ganglionic eminence cells in experimental stroke model.
- Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity.
- Striatal plasticity and basal ganglia circuit function.
- Understanding synapses: past, present, and future.
- RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.
- Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area.
- Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC.
- Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex.
- CREB modulates the functional output of nucleus accumbens neurons: a critical role of N-methyl-D-aspartate glutamate receptor (NMDAR) receptors.
- Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD.
- Endocytosis and recycling of AMPA receptors lacking GluR2/3.
- Synaptic plasticity: multiple forms, functions, and mechanisms.
- Mechanisms underlying dedepression of synaptic NMDA receptors in the hippocampus.
- Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI.
- Mechanisms for synapse specificity during striatal long-term depression.
- Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.
- Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
- Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function.
- Neuronal pentraxins mediate synaptic refinement in the developing visual system.
- Substrate localization creates specificity in calcium/calmodulin-dependent protein kinase II signaling at synapses.
- LTP: AMPA receptors trading places.
- CREB modulates excitability of nucleus accumbens neurons.
- Transsynaptic signaling by postsynaptic synapse-associated protein 97.
- Neural mechanisms of addiction: the role of reward-related learning and memory.
- Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.
- GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling.
- Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses.
- Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha.
- Generation of silent synapses by acute in vivo expression of CaMKIV and CREB.
- Cocaine-induced plasticity of intrinsic membrane properties in prefrontal cortex pyramidal neurons: adaptations in potassium currents.
- LTP and LTD: an embarrassment of riches.
- Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
- Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats.
- Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release.
- Excitation-neurogenesis coupling in adult neural stem/progenitor cells.
- Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors.
- The addicted brain.
- Beta-catenin is critical for dendritic morphogenesis.
- Synaptic plasticity and AMPA receptor trafficking.
- Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons.
- A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission.
- A developmental switch in the signaling cascades for LTP induction.
- A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors.
- Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine.
- Differential roles for NSF and GRIP/ABP in AMPA receptor cycling.
- Control of synaptic strength by glial TNFalpha.
- AMPA receptor trafficking and synaptic plasticity.
- RIM1alpha is required for presynaptic long-term potentiation.
- RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.
- Regulation of synaptic strength by protein phosphatase 1.
- Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine.
- An ER retention signal explains differences in surface expression of NMDA and AMPA receptor subunits.
- Addiction and the brain: the neurobiology of compulsion and its persistence.
- Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons.
- Role of AMPA receptor endocytosis in synaptic plasticity.
- NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses.
- Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD.
- Basic science in psychiatry.
Schools
Stanford University
Doctors Specialties
- Psychiatry
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
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